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Nikolaos Stergiopoulos

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Publications associées (238)

Tumescense monitoring system for diagnosing erectile dysfunction and methods of use

Nikolaos Stergiopoulos, Rodrigo Araujo Fraga Da Silva

Systems and methods for monitoring penile tumescence are provided that overcome the drawbacks of previously known systems by providing a wearable formed of a flexible and elastic tube having a plurality of sensors disposed on or embedded within it, the wea ...

2023

Modulation of Pulsatile Left Ventricular Afterload by Renal Denervation in Heart Failure With Preserved Ejection Fraction

Nikolaos Stergiopoulos, Stamatia Zoi Pagoulatou

Background:Arterial stiffening contributes to hemodynamic derangements in heart failure with preserved ejection fraction (HFpEF). We sought to investigate the impact of renal denervation on pulsatile left ventricular loading in patients with HFpEF and hype ...

Lippincott Williams & Wilkins2023

Cardiac output estimated from an uncalibrated radial blood pressure waveform: validation in an in-silico-generated population

Nikolaos Stergiopoulos, Vasiliki Bikia, Georgios Rovas

Background: Cardiac output is essential for patient management in critically ill patients. The state-of-the-art for cardiac output monitoring bears limitations that pertain to the invasive nature of the method, high costs, and associated complications. Hen ...

FRONTIERS MEDIA SA2023

The Impact of Left Ventricular Performance and Afterload on the Evaluation of Aortic Valve Stenosis: A 1D Mathematical Modeling Approach

Nikolaos Stergiopoulos

The transaortic valvular pressure gradient (TPG) plays a central role in decision-making for patients suffering from severe aortic stenosis. However, the flow-dependence nature of the TPG makes the diagnosis of aortic stenosis challenging since the markers ...

MDPI2023

Assessment Of Stiffness Of Large To Small Arteries In Multi-Stage Renal Disease: A Numerical Study

Nikolaos Stergiopoulos, Patrick Segers, Vasiliki Bikia

LIPPINCOTT WILLIAMS & WILKINS2022

Prognostic Implications of the Novel Pulmonary Hypertension Definition in Patients with Aortic Stenosis after Transcatheter Valve Replacement

Nikolaos Stergiopoulos, Stamatia Zoi Pagoulatou, Vasiliki Bikia, Georgios Rovas

Introduction: Pulmonary hypertension (PH), traditionally defined as a mean pulmonary artery pressure (PAP) >= 25 mmHg, is associated with poor outcomes in patients undergoing a transcatheter aortic valve replacement (TAVR) for severe aortic stenosis (AS). ...

MDPI2022

Validation of a Non-invasive Inverse Problem-Solving Method for Stroke Volume

Nikolaos Stergiopoulos, Stamatia Zoi Pagoulatou, Emma Marie Roussel, Vasiliki Bikia, Georgios Rovas

Stroke volume (SV) is a major biomarker of cardiac function, reflecting ventricular-vascular coupling. Despite this, hemodynamic monitoring and management seldomly includes assessments of SV and remains predominantly guided by brachial cuff blood pressure ...

FRONTIERS MEDIA SA2022

p-Aminobenzamidine attenuates cardiovascular dysfunctions in spontaneously hypertensive rats

Nikolaos Stergiopoulos, Fabiana Pereira Da Costa Fraga, Allancer Divino De Carvalho Nunes

Aims:Diminazene aceturate, a putative ACE2 activator, is susceptible to cleavage resulting in the formation of paminobenzamidine (PAB). This study aimed to investigate the effects of PAB in addressing cardiovascular dysfunctions in spontaneously hypertensi ...

PERGAMON-ELSEVIER SCIENCE LTD2022

Low-Intensity Electrostimulation Enhances Neuroregeneration and Improves Erectile Function in a Rat Model of Cavernous Nerve Injury

Nikolaos Stergiopoulos, Mikaël Nils Sturny, Rodrigo Araujo Fraga Da Silva

Background: Neurogenic erectile dysfunction (ED) following radical prostatectomy (RP) is a frequent complication often leading to erectile tissue remodeling and permanent ED. Low-intensity electrostimulation (LIES) has been shown to enhance peripheral nerv ...

ELSEVIER SCI LTD2022

Arterial Wave Reflection and Aortic Valve Stenosis: Diagnostic Challenges and Prognostic Significance

Nikolaos Stergiopoulos, Stamatia Zoi Pagoulatou, Vasiliki Bikia, Georgios Rovas

IntroductionArterial wave reflection is an important component of the left ventricular afterload, affecting both pressure and flow to the aorta. The aim of the present study was to evaluate the impact of wave reflection on transvalvular pressure gradients ...

FRONTIERS MEDIA SA2022

Assessment of Stiffness of Large to Small Arteries in Multistage Renal Disease Model: A Numerical Study

Nikolaos Stergiopoulos, Patrick Segers, Vasiliki Bikia

Arterial stiffness (AS), as assessed via pulse wave velocity (PWV), is a major biomarker for cardiovascular risk assessment in patients with chronic kidney disease (CKD). However, the mechanisms responsible for the changes in PWV in the presence of kidney ...

FRONTIERS MEDIA SA2022

Pre-interventional pulmonary hypertension predicts mortality in patients with aortic stenosis after transcatheter aortic valve replacement. A definition update

Nikolaos Stergiopoulos, Stamatia Zoi Pagoulatou, Vasiliki Bikia, Georgios Rovas

E M H SWISS MEDICAL PUBLISHERS LTD2022

Apelin-13 Protects Corpus Cavernosum Against Fibrosis Induced by High-Fat Diet in an MMP-Dependent Mechanism

Nikolaos Stergiopoulos, Rafaela Fernandes Da Silva, Mikaël Nils Sturny, Fabiana Pereira Da Costa Fraga, Léa Liliane Colette Anguenot, Maiia Bragina, Augusto Martins Lima

Background: An increased fibrosis of the corpora cavernosa is a prevalent process that underlies most cases of erectile dysfunction. Apelin, an endogenous circulating peptide, has been documented as an important effector on cardiovascular homeostasis, cont ...

ELSEVIER SCI LTD2021

AI-Based Estimation of End-Systolic Elastance From Arm-Pressure and Systolic Time Intervals

Nikolaos Stergiopoulos, Stamatia Zoi Pagoulatou, Vasiliki Bikia, Georgios Rovas

Left ventricular end-systolic elastance (Ees) is a major determinant of cardiac systolic function and ventricular-arterial interaction. Previous methods for the Ees estimation require the use of the echocardiographic ejection fraction (EF). However, given ...

2021

In vivo application and validation of a novel noninvasive method to estimate the end-systolic elastance

Nikolaos Stergiopoulos, Stamatia Zoi Pagoulatou, Vasiliki Bikia, Georgios Rovas

Accurate assessment of the left ventricular (LV) systolic function is indispensable in the clinic. However, estimation of a precise index of cardiac contractility, i.e., the end-systolic elastance (E-es), is invasive and cannot be established as clinical r ...

2021

Apparatus for treating excess intraocular fluid having an elastic membrane

Nikolaos Stergiopoulos, Constantinos Stergiopulos

Apparatus and methods are provided for treating diseases that produce elevated intraocular pressures, such as glaucoma, wherein the device includes a housing shell defining a cavity between a first end and a second end of the housing shell, and an elastic ...

2021

The effect of left ventricular contractility on arterial hemodynamics: A model-based investigation

Nikolaos Stergiopoulos, Stamatia Zoi Pagoulatou, Vasiliki Bikia, Georgios Rovas

Ventricular-arterial coupling is a major determinant of cardiovascular performance, however, there are still inherent difficulties in distinguishing ventricular from vascular effects on arterial pulse phenotypes. In the present study, we employed an extens ...

2021

Follicular regulatory helper T cells control the response of regulatory B cells to a high-cholesterol diet

Nikolaos Stergiopoulos

Aims B cell functions in the process of atherogenesis have been investigated but several aspects remain to be clarified. ...

OXFORD UNIV PRESS2021

Acute and Long-Term Effects of Aortic Compliance Decrease on Central Hemodynamics: A Modeling Analysis

Nikolaos Stergiopoulos, Stamatia Zoi Pagoulatou, Vasiliki Bikia, Georgios Rovas

Aortic compliance is an important determinant of cardiac afterload and a contributor to cardiovascular morbidity. In the present study, we sought to provide in silico insights into the acute as well as long-term effects of aortic compliance decrease on cen ...

FRONTIERS MEDIA SA2021

The effect of the elongation of the proximal aorta on the estimation of the aortic wall distensibility

Nikolaos Stergiopoulos, Bram Trachet, Stamatia Zoi Pagoulatou, Mauro Ferraro, Vasiliki Bikia, Georgios Rovas

The compliance of the proximal aortic wall is a major determinant of cardiac afterload. Aortic compliance is often estimated based on cross-sectional area changes over the pulse pressure, under the assumption of a negligible longitudinal stretch during the ...

2021

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