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Hubert van den Bergh

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Publications associées (145)

Synthesis and characterization of a new class of anti-angiogenic agent based on ruthenium clusters

Hubert van den Bergh, Paul Joseph Dyson, Patrycja Nowak-Sliwinska, Alexey Nazarov, Michael Groessl, Olivier Pierre Zava, Mathurin Baquié

New triruthenium-carbonyl clusters derivatized with glucose-modified bicyclophosphite ligands have been synthesized. These compounds were found to have cytostatic and cytotoxic activity and depending on the number of bicyclophosphite ligands, and could be ...

Nature Publishing Group2013

Raman Lidar for Meteorological Observations, RALMO - Part 1: Instrument description

Bertrand Calpini, Hubert van den Bergh, Valentin Simeonov, Pablo Roberto Ristori, Todor Dinoev, Marc Parlange

A new Raman lidar for unattended, round-the-clock measurement of vertical water vapor profiles for operational use by the MeteoSwiss has been developed during the past years by the Swiss Federal Institute of Technology, Lausanne. The lidar uses narrow fiel ...

European Geosciences Union2013

Correlations between photoactivable porphyrins’ fluorescence, erythema and the pain induced by PDT on normal skin using ALA-derivatives

Hubert van den Bergh, Georges Wagnières, Matthieu Philippe Emmanuel Zellweger, Jérôme Barge

Summary Background Photodynamic therapy (PDT) with precursors of photoactivable porphyrins is a well-established treatment modality for skin pathologies as well as hair removal. Pain is a major side effect thereof, and it affects the treatment compliance a ...

Elsevier2013

Device for application of medium to human tissue or animal body such as eye, has carrier which is provided with micro-cavity for containing medium in direct contact with object on which medium is to be applied

Hubert van den Bergh, Philippe Renaud, Yann Barrandon, Thomas Michael Braschler, Julien Graber

NOVELTY - The device has a carrier (1) which is provided with micro-cavity (2) for containing medium in direct contact with the object on which the medium is to be applied. Other carrier is provided with ring to protect the medium from environment when the ...

2013

Photodynamic therapy for polypoidal choroidal vasculopathy

Hubert van den Bergh, Patrycja Nowak-Sliwinska

The first effective therapy for exudative macular degeneration (AMD) was Photodynamic Therapy (PDT). Diagnosis of the disease was to a large extent by fluorescein angiography (FA). Distinguishing between the leaky choroidal neovessels (CNV) associated with ...

Pergamon-Elsevier Science Ltd2013

A Raman lidar to measure water vapor in the atmospheric boundary layer

Hubert van den Bergh, Valentin Simeonov, Martin Froidevaux, Pablo Roberto Ristori, Marc Parlange, Ilya Serikov, Chad Higgins, Eric Richard Pardyjak

A new multi-telescope scanning Raman lidar designed to measure the water vapor mixing ratio in the atmospheric boundary layer for a complete diurnal cycle with high resolution spatial (1.25 m) and temporal (1 s) resolutions is presented. The high resolutio ...

Elsevier2013

Probing the Interaction Between a Surfactant-Cobalt(III) Complex and Bovine Serum Albumin

Hubert van den Bergh, Georges Wagnières

The mechanism of binding of the surfactant-cobalt(III) complex, cis-[Co(phen) 2(C 14H 29NH 2)Cl](ClO 4) 2{dot operator}3H 2O (phen = 1,10-phenanthroline, C 14H 29NH 2 = tetradecylamine) with bovine serum albumin (BSA) was investigated by UV-vis absorption, ...

Springer US2012

Angiogenesis inhibition by the maleimide-based small molecule GNX-686

Hubert van den Bergh, Georges Wagnières, Patrycja Nowak-Sliwinska

We investigated the anti-angiogenic properties of GNX-686, a newly identified maleimide-based small molecule. In vitro studies on HUVEC showed that GNX-686 inhibited cell growth with an ED50 of 20-25 mu M, while human HeLa tumor cells and non-transformed e ...

Elsevier2012

Photodynamic induced uptake of liposomal doxorubicin to rat lung tumors parallels tumor vascular density

Hubert van den Bergh, Elodie Debefve, Laurent Décosterd

Visudyne®-mediated photodynamic therapy (PDT) at low drug/light conditions has shown to selectively enhance the uptake of liposomal doxorubicin in subpleural localized sarcoma tumors grown on rodent lungs without causing morphological alterations of the lu ...

2012

Angiostatic kinase inhibitors to sustain photodynamic angio-occlusion

Hubert van den Bergh, Patrycja Nowak-Sliwinska, Blaise Lovisa

Targeted angiostatic therapy receives major attention for the treatment of cancer and exudative age-related macular degeneration (AMD). Photodynamic therapy (PDT) has been used as an effective clinical approach for these diseases. Since PDT can cause an an ...

2012

Like a Bolt from the Blue: Phthalocyanines in Biomedical Optics

Hubert van den Bergh

The purpose of this review is to compile preclinical and clinical results on phthalocyanines (Pcs) as photosensitizers (PS) for Photodynamic Therapy (PDT) and contrast agents for fluorescence imaging. Indeed, Pcs are excellent candidates in these fields du ...

Molecular Diversity Preservation International2012

Photodynamic drug delivery enhancement in tumours does not depend on leukocyte-endothelial interaction in a human mesothelioma xenograft model

Hubert van den Bergh, Elodie Debefve, Hans-Anton Lehr

OBJECTIVES: The pre-treatment of tumour neovessels by low-level photodynamic therapy (PDT) improves the distribution of concomitantly administered systemic chemotherapy. The mechanism by which PDT permeabilizes the tumour vessel wall is only partially know ...

Oxford University Press2012

Imidazoacridinone-dependent lysosomal photodestruction: a pharmacological Trojan horse approach to eradicate multidrug-resistant cancers

Hubert van den Bergh, Patrycja Nowak-Sliwinska

Multidrug resistance (MDR) remains a primary hindrance to curative cancer therapy. Thus, introduction of novel strategies to overcome MDR is of paramount therapeutic significance. Sequestration of chemotherapeutics in lysosomes is an established mechanism ...

2012

Real-time, in vivo measurement of tissular pO(2) through the delayed fluorescence of endogenous protoporphyrin IX during photodynamic therapy

Hubert van den Bergh, Georges Wagnières, Filippo Piffaretti, Cédric Xavier Paulou, Patrycja Nowak-Sliwinska, Anna Maria Novello

Tissular oxygen concentration plays a key role during photodynamic therapy (PDT). Therefore, monitoring its local oxygen partial pressure (pO(2)) may help predict and/or control the outcome of a PDT treatment. The first real-time, in vivo measurements of t ...

SPIE Society of Photo-optical Instrumentation Engineers2012

Optical fiber-based setup for in vivo measurement of the delayed fluorescence lifetime of oxygen sensors

Hubert van den Bergh, Georges Wagnières, Filippo Piffaretti

A new optical-fiber-based spectrofluorometer for in vivo or in vitro detection of delayed fluorescence is presented and characterized. This compact setup is designed so that it can be readily adapted for future clinical use. Optical excitation is done with ...

SPIE Society of Photo-optical Instrumentation Engineers2011

Low dose endoluminal photodynamic therapy improves murine T cell-mediated colitis

Hubert van den Bergh, Georges Wagnières, Tanja Gabrecht, François André Borle, Dominique Velin

Background and study aims: Low dose photodynamic therapy (LDPDT) may modify the mucosal immune response and may thus provide a therapy for Crohn's disease. We evaluated the efficacy and safety of this technique in a murine T cell-mediated colitis model. ...

2011

Organometallic Ruthenium(II) Arene Compounds with Antiangiogenic Activity

Hubert van den Bergh, Georges Wagnières, Paul Joseph Dyson, Patrycja Nowak-Sliwinska, Alexey Nazarov, Angela Casini

The antimetastatic ruthenium (II) compounds [Ru(eta(6)-p-cymene)Cl-2(PTA)] (PTA = 1,3,5-triaza-7-phosphaadamantane) (RAPTA-C) and [Ru(eta(6)-toluene)Cl-2(PTA)] (RAPTA-T), as well as their analogues [Ru(eta(6)-p-cymene)Cl-2(DAPTA)] (DAPTA = (3,7-diacetyl-1, ...

2011

It is All About Proteases: From Drug Delivery to In Vivo Imaging and Photomedicine

Hubert van den Bergh

Clinical studies provide overwhelming evidence for the importance of proteolytic imbalance and the upregulation of diverse protease classes in diseases such as cancer and arthritis. While the complex nature of proteolytic networks has hampered the developm ...

Bentham Science Publishers2011

Study of the pO2-sensitivity of the dendrimeric and free forms of Pd-meso-tetra(4-carboxyphenyl)porphyrin, incorporated or not in chitosan-based nanoparticles

Hubert van den Bergh, Georges Wagnières, Peter Käuper, Patrycja Nowak-Sliwinska

The concentration of oxygen and its rate of consumption are important factors in certain medical treatments, such as radiotherapy and photodynamic therapy (PDT). Measuring the tissue concentration of oxygen or its partial pressure (pO2) can be achieved by ...

Schweizerische Chemische Gesellschaft2011

Photodynamic therapy enhances liposomal doxorubicin distribution in tumors during isolated perfusion of rodent lungs

Hubert van den Bergh, Elodie Debefve, Yi Wang

Background: Photodynamic therapy (PDT) at low drug-light conditions can enhance the transport of intravenously injected macromolecular therapeutics through the tumor vasculature. Here we determined the impact of PDT on the distribution of liposomal doxorub ...

Karger2011

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