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Hubert van den Bergh

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Publications associées (145)

Photodynamic therapy of early squamous cell carcinoma with tetra(m-hydroxyphenyl)chlorin: optimal drug-light interval

Hubert van den Bergh, Georges Wagnières

The optimal drug-light interval for effective photodynamic therapy (PDT) of early squamous cell carcinomas was evaluated with tetra(m-hydroxyphenyl)chlorin (mTHPC) by means of two complementary modalities: irradiation tests and ex vivo fluorescence microsc ...

1997

Photodynamic therapy for early squamous cell carcinomas of the esophagus, bronchi, and mouth with m-tetra(hydroxyphenyl) chlorin

Hubert van den Bergh, Georges Wagnières

Objective: To clinically evaluate a new photosensitizer, m- tetra(hydroxyphenyl) chlorin (m-THPC), for the photodynamic therapy of early squamous cell carcinomas of the upper aerodigestive tract. Design: Phase 1 included evaluation of the innocuousness of ...

1997

An endoscopic fluorescence imaging system for simultaneous visual examination and photodetection of cancers

André Studzinski, Hubert van den Bergh, Georges Wagnières

We describe the design and performance tested during six years of clinical trials of a fluorescence endoscope for the detection and delineation of cancers in several hollow organs. The apparatus is based on the imaging of the laser-induced fluorescence tha ...

1997

EPR and spectrophotometric studies of free radicals (O2.-, .OH, BPD-MA.-) and singlet oxygen (1O2) generated by irradiation of benzoporphyrin derivative monoacid ring A

Hubert van den Bergh, Georges Wagnières

Benzoporphyrin deriv. monoacid ring A [BPD-MA (I)], a chlorin-type mol., is a new photosensitizer currently in phase II clin. trials for the treatment by photodynamic therapy of cancerous lesions, psoriasis and pathol. neovascularization. The photochem. (t ...

1997

Light dosimetry for photodynamic therapy in the esophagus

Hubert van den Bergh, Georges Wagnières

BACKGROUND AND OBJECTIVE: Photodynamic therapy (PDT) is an efficient technique to treat superficial early cancers in the pharynx, esophagus, and tracheo-bronchial tree. However, the lack of selectivity of some of the clinically used photosensitizers can re ...

1997

Three-dimensional optical phantom and its application in photodynamic therapy

Hubert van den Bergh, Georges Wagnières

BACKGROUND AND OBJECTIVE: A technique to manufacture a stable, reproducible three-dimensional optical phantom is presented. This phantom reproduces the tissue's optical properties as well as the geometry and, to some extent, the mechanical properties of th ...

1997

Production of the free radicals O-2(.-) and OH by irradiation of the photosensitizer zinc(II) phthalocyanine

Hubert van den Bergh, Georges Wagnières

Zinc(II) phthalocyanine (ZnPC) is a new photosensitizer currently undergoing phase I and II clinical trials at Lausanne's CHUV hospital for the photodynamic therapy (PDT) of early cancer in the upper aerodigestive tract. Activated oxygen species other than ...

1997

An optical phantom with tissue-like properties in the visible for use in PDT and fluorescence spectroscopy

Hubert van den Bergh, Georges Wagnières, Matthieu Philippe Emmanuel Zellweger

1997

Clinical imaging fluorescence apparatus for the endoscopic photodetection of early cancers by use of Photofrin II

Christian Depeursinge, André Studzinski, Hubert van den Bergh, Georges Wagnières, André Châtelain

A fluorescence imaging device applied to the detection of early cancer is described. The app. is based on the imaging of laser-induced fluorescence of a dye that localizes in a tumor with a higher concn. than in the surrounding normal tissue after i.v. inj ...

Optical Society of America1997

Clinical determination of tissue optical properties by endoscopic spatially resolved reflectometry

Hubert van den Bergh, Georges Wagnières

1996

Tetra(m-hydroxyphenyl)chlorin clinical photodynamic therapy of early bronchial and oesophageal cancers

Hubert van den Bergh, Georges Wagnières, Alain Woodtli

1996

Optimizing light dosimetry in photodynamic therapy of the bronchi by fluorescence spectroscopy

Hubert van den Bergh, Georges Wagnières

1996

Measurements by fluorescence microscopy of the time-dependent distribution of meso-tetra-hydroxyphenylchlorin in healthy tissues and chemically induced ''early'' squamous cell carcinoma of the Syrian hamster cheek pouch

Hubert van den Bergh, Georges Wagnières

The influence of the time interval between dye administration and detection by fluorescence microscopy was assessed in "early" squamous cell carcinomas of the cheek pouch mucosa and different healthy tissues of the Syrian hamster. Following intracardiac ...

1996

Photodynamic Therapy for Cancer of the Upper Aerodigestive Tract Using Tetra(m-hydroxyphenyl)chlorin

Hubert van den Bergh, Georges Wagnières, Alain Woodtli

A major step in the development of photodynamic therapy (PDT) is the clinical optimization and evaluation of new photosensitizers (PS). Ideally, new compounds should be more effective and/or induce fewer side effects than the first generation PS such as he ...

1996

In-vivo fluence rate effect in photodynamic therapy of early cancers with tetra(m-hydroxyphenyl)chlorin

Hubert van den Bergh, Georges Wagnières, Alain Woodtli

Several parameters affect clin. trials in photodynamic therapy and influence the therapeutic outcome. Beside drug dose, light dose, drug-light interval and other variables, the fluence rate is a parameter that can influence the therapeutic results. In this ...

1996

Clinical pharmacokinetic studies of tetra(meta-hydroxyphenyl)chlorin in squamous cell carcinoma by fluorescence spectroscopy at 2 wavelengths

Hubert van den Bergh, Georges Wagnières

To optimize photodynamic therapy (PDT) and photodetection of cancer with second-generation photosensitizers, knowledge of important variables such as the uptake of the dye and the dye contrast between normal and tumoral tissue after injection is necessary. ...

1995

Clinical pharmacokinetic studies of photofrin by fluorescence spectroscopy in the oral cavity, the esophagus, and the bronchi

Hubert van den Bergh, Georges Wagnières

Background. To optimize photodynamic therapy (PDT) and photodetection of cancer, two important variables that must be considered are the uptake of the dye and the dye contrast between normal and neoplastic tissue after injection. Methods. To study these va ...

1995

Antibody-indocyanin conjugates for immunophotodetection of human squamous cell carcinoma in nude mice

Hubert van den Bergh, Georges Wagnières

The authors have recently shown that immunophotodetection of human colon carcinomas in nude mice and in patients is possible by using anti-carcinoembryonic antigen monoclonal antibodies (MAb) coupled to fluorescein. The most common clin. application of pho ...

1994

Preliminary clinical results on a second generation photosensitizer: mTHPC

Hubert van den Bergh, Georges Wagnières

Elsevier Science & Technology Books1992

Clinical pharmacokinetic studies of Photofrin II by fluorescence spectroscopy

Hubert van den Bergh, Georges Wagnières

Elsevier Science Publishers B.V.1992

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