Publications de Jacques Van Der Klink

Photoinduced Nonpersistent Radicals as Polarizing Agents for X-Nuclei Dissolution Dynamic Nuclear Polarization

Arnaud Comment, Jacques Van Der Klink, Giovanni Boero, Christophe Roussel, Tian Cheng, Tim Rolf Eichhorn, Jean-Noël Hyacinthe, Andrea Capozzi

Hyperpolarization via dissolution dynamic nuclear polarization (DNP) is a versatile method to dramatically enhance the liquid-state NMR signal of X-nuclei and can be used for performing metabolic and molecular imaging. It was recently demonstrated that ins ...

American Chemical Society2015

An apparatus for pulsed ESR and DNP experiments using optically excited triplet states down to liquid helium temperatures

Arnaud Comment, Jacques Van Der Klink, Sami Jannin, Tim Rolf Eichhorn, Martin Haag

In standard Dynamic Nuclear Polarization (DNP) electron spins are polarized at low temperatures in a strong magnetic field and this polarization is transferred to the nuclear spins by means of a microwave field. To obtain high nuclear polarizations cryogen ...

Academic Press2013

Development and characterization of an automated dissolution-DNP setup for in vivo hyperpolarized MRS and MRI in rodent at 14.1T

Arnaud Comment, Jacques Van Der Klink, Riccardo Balzan, Tian Cheng

2011

Infusion pump with phase separator

Arnaud Comment, Jacques Van Der Klink

An infusion pump comprising a substance and pushing fluid inlet, a substance outlet, a central chamber communicating with said inlet and said outlet, and injecting means for injecting a substance into a biological object, wherein the infusion pump further ...

2011

Relation between susceptibility and Knight shift in La2NiO4.17 and K2NiF4 by Ni-61 NMR

Jacques Van Der Klink

The NiO4 plaquettes in La2NiO4.17, a cousin of the hole-doped high-temperature superconductor La2-xSrxCuO4, have been studied by Ni-61 NMR in 14 T in a single crystal enriched in Ni-61. Doped and undoped plaquettes are discriminated by the shift of the NMR ...

2010

Hyperpolarized Lithium-6 as a Sensor of Nanomolar Contrast Agents

Arnaud Comment, Jacques Van Der Klink, Chiara Perazzolo, Rolf Gruetter, Sami Jannin, Ruud van Heeswijk, Fiodar Kurdzesau, Cristina Ramona Cudalbu

Lithium is widely used in psychotherapy. The Li-6 isotope has a long intrinsic longitudinal relaxation time T-1 on the order of minutes, making it an ideal candidate for hyperpolarization experiments. In the present study we demonstrated that lithium-6 can ...

Wiley-Blackwell2009

Dynamic nuclear polarization of small labelled molecules in frozen water-alcohol solutions

Arnaud Comment, Jacques Van Der Klink, Sami Jannin, Fiodar Kurdzesau

In recent years methods of creating 'hyperpolarized' substances have gained considerable attention in biomedical magnetic resonance and dynamic nuclear polarization (DNP) is one of the most promising, especially for imaging applications. Here we present re ...

2008

Producing over 100 ml of highly concentrated hyperpolarized solution by means of dissolution DNP

Arnaud Comment, Jacques Van Der Klink, Sami Jannin, Ruud van Heeswijk, Fiodar Kurdzesau

New low-temperature inserts compatible with an existing hyperpolarizer were developed to dynamically polarize nuclei in large samples. The performance of the system was tested on 8 ml glassy frozen solutions containing 13C-labeled molecules and doped with ...

Academic Press Inc - Elsevier Science2008

A 140 GHz prepolarizer for dissolution dynamic nuclear polarization

Arnaud Comment, Jacques Van Der Klink, Sami Jannin, Fiodar Kurdzesau

Apart from their very classical use to build polarized targets for particle physics, the methods of dynamic nuclear polarization (DNP) have more recently found application for sensitivity enhancement in high-resolution NMR, both in the solid and in the liq ...

2008

Principles of operation of a DNP prepolarizer coupled to a rodent MRI scanner

Arnaud Comment, Jacques Van Der Klink, Rolf Gruetter, Sami Jannin, Fiodar Kurdzesau

A dynamic nuclear polarization prepolarizer was developed and coupled to a 9.4 T rodent magnetic resonance imaging scanner in order to perform in vivo hyperpolarization experiments. In the present paper, emphasis is put on methods and hardware performance ...

2008

Design and performance of a DNP prepolarizer coupled to a rodent MRI scanner

Arnaud Comment, Jacques Van Der Klink, Rolf Gruetter, Sami Jannin, Fiodar Kurdzesau

For most of the last forty years, the techniques of Dynamic Nuclear Polarization (DNP) have been confined to particle-physics laboratories building polarized targets, but recently it has been shown that samples similar to a solid target can be transformed ...

2007