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Matthieu Philippe Emmanuel Zellweger

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Publications associées (35)

Autofluorescence bronchoscopy: Clinical experience with an optimized system in head and neck cancer patients

Hubert van den Bergh, Georges Wagnières, Matthieu Philippe Emmanuel Zellweger, Tanja Gabrecht, Blaise Lovisa

Elsevier2007

VLSI implementation of the list sphere algorithm

Matthieu Philippe Emmanuel Zellweger, Christoph Studer, Andreas Peter Burg

Sphere decoding (SD) is widely considered as one of the most promising detection schemes for multiple-input multiple-output (MIMO) communication systems. The recently proposed list sphere-decoding (LSD) algorithm is an extension of the original SD algorith ...

Ieee Service Center, 445 Hoes Lane, Po Box 1331, Piscataway, Nj 08855-1331 Usa2006

VLSI implementation of MIMO detection using the sphere decoding algorithm

Matthieu Philippe Emmanuel Zellweger, Andreas Peter Burg

Multiple-input multiple-output (MIMO) techniques are a key enabling technology for high-rate wireless communications. This paper discusses two ASIC implementations of MIMO sphere decoders. The first ASIC attains maximum-likelihood performance with an avera ...

2005

In vivo autofluorescence imaging of early cancers in the human tracheobronchial tree with a spectrally optimized system

Hubert van den Bergh, Georges Wagnières, Matthieu Philippe Emmanuel Zellweger

The changes in the autofluorescence characteristics of the bronchial tissue is of crucial interest as a cancer diagnostic tool. Evidence exists that this native fluorescence or autofluorescence of bronchial tissues changes when they turn dysplastic and to ...

SPIE Society of Photo-optical Instrumentation Engineers2003

In vivo autofluorescence spectroscopy of human bronchial tissue to optimize the detection and imaging of early cancers

Hubert van den Bergh, Georges Wagnières, Matthieu Philippe Emmanuel Zellweger

We are developing an imaging system to detect pre-/early cancers in the tracheo-bronchial tree. Autofluorescence might be useful but many features remain suboptimal. We have studied the autofluorescence of human healthy, metaplastic and dysplastic/CIS bron ...

SPIE Society of Photo-optical Instrumentation Engineers2001

Absolute autofluorescence spectra of human healthy, metaplastic, and early cancerous bronchial tissue in vivo

Hubert van den Bergh, Georges Wagnières, Matthieu Philippe Emmanuel Zellweger

Autofluorescence is emerging as a useful tool for the detection of early cancers in the bronchi. It has already produced interesting results, which have been implemented in commercial imaging devices. Their design relies on the spectroscopy of the tissues ...

2001

Fluorescence spectroscopy of exogenous, exogenously-induced and endogenous fluorophores for the photodetection and photodynamic therapy of cancer

Matthieu Philippe Emmanuel Zellweger

EPFL2000

5-Aminolevulinic acid and its derivatives: physical chemical properties and protoporphyrin IX formation in cultured cells

Hubert van den Bergh, Georges Wagnières, Matthieu Philippe Emmanuel Zellweger, Pascal Uehlinger

Protoporphyrin IX (PpIX) is used as a fluorescence marker and photosensitizing agent in photodynamic therapy (PDT). A temporary increase of PpIX in tissues can be obtained by administration of 5-aminolevulinic acid (ALA). Lipophilicity is one of the key pa ...

2000

Fluorescence pharmacokinetics of Lutetium Texaphyrin (PCI-0123, Lu-Tex) in the skin and in healthy and tumoral hamster cheek-pouch mucosa

Hubert van den Bergh, Georges Wagnières, Matthieu Philippe Emmanuel Zellweger

We have investigated the pharmacokinetics (PK) of Lutetium Texaphyrin (Lu-Tex), a second-generation photosensitizer, in the Syrian hamster cheek pouch early cancer model. Ten male hamsters, five with chem. induced early squamous cell cancer of the left che ...

Elsevier2000

Stability of the fluorescence measurement of Foscan in the normal human oral cavity as an indicator of its content in early cancers of the esophagus and the bronchi

Hubert van den Bergh, Georges Wagnières, Matthieu Philippe Emmanuel Zellweger

Photodynamic therapy (PDT) with Foscan (mTHPC) is used to cure early cancers of the esophagus or the tracheobronchial tree. However, fixed PDT parameters (drug dose, light dose, etc.) do not permit an accurate prediction of the tissue damage. Large interpa ...

1999

Photodetection of early human bladder cancer based on the fluorescence of 5-aminolaevulinic acid hexylester-induced protoporphyrin IX: a pilot study

Hubert van den Bergh, Georges Wagnières, Matthieu Philippe Emmanuel Zellweger, Pavel Kucera

Exogenous administration of 5-aminolaevulinic acid (ALA) is becoming widely used to enhance the endogenous synthesis of protoporphyrin IX (PpIX) in photodynamic therapy (PDT) and fluorescence photodetection (PD). Recently, results have shown that the chemi ...

1999

Photoeradication of Helicobacter pylori in humans: Phase 1 study

Hubert van den Bergh, Georges Wagnières, Alain Woodtli, Matthieu Philippe Emmanuel Zellweger

1999

Solution for diagnosing or treating tissue pathology

Hubert van den Bergh, Georges Wagnières, Matthieu Philippe Emmanuel Zellweger, Pavel Kucera

PROBLEM TO BE SOLVED: To provide a composition for diagnosing and/or treating cancerous pathologies in the field of urology. ;SOLUTION: The invention relates to a 5-aminolevulinic acid ester (E-ALA) solution for producing a pharmaceutical preparation usefu ...

1999

Pharmacokinetics of tetra(m-hydroxyphenyl)chlorin in human plasma and individualized light dosimetry in photodynamic therapy

Hubert van den Bergh, Georges Wagnières, Matthieu Philippe Emmanuel Zellweger

The pharmacokinetics of the photosensitizer 5,10,15,20-tetra(m-hydroxyphenyl)chlorin (mTHPC) was investigated in the plasma of 20 patients by absorption and fluorescence spectroscopy. The temporal behavior was characterized by a rapid decrease in concn. du ...

1998

An optical phantom with tissue-like properties in the visible for use in PDT and fluorescence spectroscopy

Hubert van den Bergh, Georges Wagnières, Matthieu Philippe Emmanuel Zellweger

1997

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