Publications de Tania Rinaldi | EPFL Graph Search

Enhanced long-term microcircuit plasticity in the valproic Acid animal model of autism

Tania Rinaldi, Jean-Vincent Le Bé, Henry Markram, Kamila Markram, Imad Riachi, Guilherme Silva

A single intra-peritoneal injection of valproic acid (VPA) on embryonic day (ED) 11.5 to pregnant rats has been shown to produce severe autistic-like symptoms in the offspring. Previous studies showed that the microcircuitry is hyperreactive due to hyperco ...

2009

Hyper-connectivity and hyper-plasticity in the medial prefrontal cortex in the valproic Acid animal model of autism

Tania Rinaldi, Henry Markram, Catherine Perrodin

The prefrontal cortex has been extensively implicated in autism to explain deficits in executive and other higher-order functions related to cognition, language, sociability and emotion. The possible changes at the level of the neuronal microcircuit are ho ...

2008

Abnormal fear conditioning and amygdala processing in an animal model of autism

Tania Rinaldi, Deborah La Mendola, Henry Markram, Maria del Carmen Sandi Perez, Kamila Markram

A core feature of autism spectrum disorders is the impairment in social interactions. Among other brain regions, a deficit in amygdala processing has been suggested to underlie this impairment, but whether the amygdala is processing fear abnormally in auti ...

Nature Publishing Group2008

Hyperconnectivity of Local Neocortical Microcircuitry Induced by Prenatal Exposure to Valproic Acid

Tania Rinaldi, Henry Markram, Gilad Silberberg

Exposure to valproic acid (VPA) during embryogenesis can cause several teratogenic effects, including developmental delays and in particular autism in humans if exposure occurs during the third week of gestation. We examined the postnatal effects of embryo ...

Oxford University Press2007

The intense world syndrome – an alternative hypothesis for autism

Tania Rinaldi, Henry Markram, Kamila Markram

Autism is a devastating neurodevelopmental disorder with a polygenetic predisposition that seems to be triggered by multiple environmental factors during embryonic and/or early postnatal life. While significant advances have been made in identifying the ne ...

2007

Methods For Treating And/Or Preventing Pervasive Developmental Disorders In A Subject

Tania Rinaldi, Henry Markram, Karina Kulangara

The present invention concerns a method for treating and/or preventing a Pervasive Developmental Disorder in a subject in need thereof comprising the step of modulating the synaptic connectivity in the neocortex by administering a therapeutically effective ...

2007

Elevated NMDA receptor levels and enhanced postsynaptic long-term potentiation induced by prenatal exposure to valproic acid

Tania Rinaldi, Henry Markram, Karina Kulangara

Valproic acid (VPA) is a powerful teratogen causing birth defects in humans, including autism spectrum disorder (ASD), if exposure occurs during the first trimester of embryogenesis. Learning and memory alterations are common symptoms of ASD, but underlyin ...

National Academy of Sciences2007

Altered neocortical microcircuitry in the valproic acid rat model of autism

Tania Rinaldi

Autism is a wide-spectrum disorder with early childhood onset, affecting general cognitive capabilities and, in particular, complex information processing. Although interesting directions of research start to appear, the precise causes of the disorder and ...

EPFL2006