Publications de Sylvain Eric Lengacher

Lactate enhancing compounds and uses thereof

Sylvain Eric Lengacher, Pierre Magistretti, Charles Léonard Finsterwald

Abstract of the invention: The present invention relates to new agents useful for stimulating release of lactate by astrocytes. The invention further relates to methods of preparation, formulations and therapeutic uses of those agents, notably for the prev ...

2020

Impact of MCT1 Haploinsufficiency on the Mouse Retina

Sylvain Eric Lengacher, Pierre Magistretti, Luc Pellerin

The monocarboxylate transporter 1 (MCT1) is highly expressed in the outer retina, suggesting that it plays a critical role in photoreceptors. We examined MCT1+/- heterozygotes, which express half of the normal complement of MCT1. The MCT1(+/-) retina devel ...

SPRINGER INTERNATIONAL PUBLISHING AG2018

Extracellular Potassium and Glutamate Interact To Modulate Mitochondria in Astrocytes

Sylvain Eric Lengacher, Jean-Yves Chatton

2018

Hyperpolarized C-13 Magnetic Resonance Spectroscopy Reveals the Rate-Limiting Role of the Blood-Brain Barrier in the Cerebral Uptake and Metabolism of L-Lactate in Vivo

Arnaud Comment, Sylvain Eric Lengacher, Bernard Lanz, Mor-Miri Mishkovsky, Tian Cheng, Josefina Adriana Maria Bastiaansen, Yuhei Takado, Hikari Ananda Infinity Yoshihara

The dynamics of L-lactate transport across the blood-brain barrier (BBB) and its cerebral metabolism are still subject to debate. We studied lactate uptake and intracellular metabolism in the mouse brain using hyperpolarized C-13 magnetic resonance spectro ...

2018

Role of MCT1 and CAII in skeletal muscle pH homeostasis, energetics, and function: in vivo insights from MCT1 haploinsufficient mice

Sylvain Eric Lengacher, Pierre Magistretti, Luc Pellerin

The purpose of this study was to investigate the effects of a partial suppression of monocarboxylate transporter (MCT)-1 on skeletalmuscle pH, energetics, and function (MCT1(+/-) mice). Twenty-fourMCT1(+/-) and 13 wild-type (WT) mice were subjected to a re ...

Federation of American Society of Experimental Biology2017

Astrocytic beta(2)-adrenergic receptors mediate hippocampal long-term memory consolidation

Sylvain Eric Lengacher, Pierre Magistretti, Virginia Gao

Emotionally relevant experiences form strong and long-lasting memories by critically engaging the stress hormone/neurotransmitter noradrenaline, which mediates and modulates the consolidation of these memories. Noradrenaline acts through adrenergic recepto ...

National Academy of Sciences2016

Deficiency in monocarboxylate transporter 1 (MCT1) in mice delays regeneration of peripheral nerves following sciatic nerve crush

Sylvain Eric Lengacher, Pierre Magistretti, Luc Pellerin, Lin Jin

Peripheral nerve regeneration following injury occurs spontaneously, but many of the processes require metabolic energy. The mechanism of energy supply to axons has not previously been determined. In the central nervous system, monocarboxylate transporter ...

Elsevier2015

Learning-Induced Gene Expression in the Hippocampus Reveals a Role of Neuron-Astrocyte Metabolic Coupling in Long Term Memory

Sylvain Eric Lengacher, Pierre Magistretti, Igor Allaman, Gabriele Grenningloh, Monika Tadi

We examined the expression of genes related to brain energy metabolism and particularly those encoding glia (astrocyte)-specific functions in the dorsal hippocampus subsequent to learning. Context-dependent avoidance behavior was tested in mice using the s ...

Public Library of Science2015

Channel-Mediated Lactate Release by K+-Stimulated Astrocytes

Patrick Aebischer, Sylvain Eric Lengacher, Pierre Magistretti, Bernard Schneider

Excitatory synaptic transmission is accompanied by a local surge in interstitial lactate that occurs despite adequate oxygen availability, a puzzling phenomenon termed aerobic glycolysis. In addition to its role as an energy substrate, recent studies have ...

Society for Neuroscience2015

Astrocytes: New Targets for the Treatment of Neurodegenerative Diseases

Sylvain Eric Lengacher, Pierre Magistretti, Charles Léonard Finsterwald

The causes of neurodegenerative disorders are multiple, and for most of them a mechanistic understanding is still lacking. However, neurodegenerative diseases such as Alzheimer disease (AD), amyotrophic lateral sclerosis (ALS) and Parkinson disease (PD) al ...

Bentham Science Publishers2015

Astrocytes may be behind the pathogenesis of 22q11

Sylvain Eric Lengacher, Pierre Magistretti, Tamara Zehnder, Luca Pucci

Wiley-Blackwell2015

Cerebral glucose uptake measurements on a single cell level reveal higher transport in astrocytes in vivo

Sylvain Eric Lengacher, Pierre Magistretti

Wiley-Blackwell2015

Monocarboxylate Transporter 1 (Mct1) Is Critical For Schwann Cell Function In Regenerating Peripheral Nerves

Sylvain Eric Lengacher, Pierre Magistretti, Luc Pellerin

Wiley-Blackwell2015

Control of Mitochondrial pH by Uncoupling Protein 4 in Astrocytes Promotes Neuronal Survival

Sylvain Eric Lengacher, Pierre Magistretti, Jean-Yves Chatton, Hélène Danielle Perreten Lambert, Manuel Raphael Zenger

Brain activity is energetically costly and requires a steady and highly regulated flow of energy equivalents between neural cells. It is believed that a substantial share of cerebral glucose, the major source of energy of the brain, will preferentially be ...

American Society for Biochemistry and Molecular Biology2014

The human CFTR protein expressed in CHO cells activates aquaporin-3 in a cAMP-dependent pathway: study by digital holographic microscopy

Pierre Marquet, Sylvain Eric Lengacher, Pierre Magistretti, Pascal Jourdain

The transmembrane water movements during cellular processes and their relationship to ionic channel activity remain largely unknown. As an example, in epithelial cells it was proposed that the movement of water could be directly linked to cystic fibrosis t ...

Company of Biologists2014

Astrocyte–neuron co-culture on microchips based on the model of SOD mutation to mimic ALS

Patrick Aebischer, Philippe Renaud, Sylvain Eric Lengacher, Pierre Magistretti, Anja Kunze, Elisabeth Anne Dirren

Amyotrophic lateral sclerosis (ALS) is the most common motor neuron disease. ALS is believed to be a non-cell autonomous condition, as other cell types, including astrocytes, have been implicated in disease pathogenesis. Hence, to facilitate the developmen ...

Royal Soc Chemistry2013

Resistance to Diet-Induced Obesity and Associated Metabolic Perturbations in Haploinsufficient Monocarboxylate Transporter 1 Mice

Sylvain Eric Lengacher, Pierre Magistretti, Luc Pellerin

The monocarboxylate transporter 1 (MCT1 or SLC16A1) is a carrier of short-chain fatty acids, ketone bodies, and lactate in several tissues. Genetically modified C57BL/6J mice were produced by targeted disruption of the mct1 gene in order to understand the ...

Public Library of Science2013

Sylvain Eric Lengacher

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Lactate enhancing compounds and uses thereof

Impact of MCT1 Haploinsufficiency on the Mouse Retina

Extracellular Potassium and Glutamate Interact To Modulate Mitochondria in Astrocytes

Hyperpolarized C-13 Magnetic Resonance Spectroscopy Reveals the Rate-Limiting Role of the Blood-Brain Barrier in the Cerebral Uptake and Metabolism of L-Lactate in Vivo

Role of MCT1 and CAII in skeletal muscle pH homeostasis, energetics, and function: in vivo insights from MCT1 haploinsufficient mice

Astrocytic beta(2)-adrenergic receptors mediate hippocampal long-term memory consolidation

Deficiency in monocarboxylate transporter 1 (MCT1) in mice delays regeneration of peripheral nerves following sciatic nerve crush

Learning-Induced Gene Expression in the Hippocampus Reveals a Role of Neuron-Astrocyte Metabolic Coupling in Long Term Memory

Channel-Mediated Lactate Release by K+-Stimulated Astrocytes

Astrocytes: New Targets for the Treatment of Neurodegenerative Diseases

Astrocytes may be behind the pathogenesis of 22q11

Cerebral glucose uptake measurements on a single cell level reveal higher transport in astrocytes in vivo

Monocarboxylate Transporter 1 (Mct1) Is Critical For Schwann Cell Function In Regenerating Peripheral Nerves

Control of Mitochondrial pH by Uncoupling Protein 4 in Astrocytes Promotes Neuronal Survival

The human CFTR protein expressed in CHO cells activates aquaporin-3 in a cAMP-dependent pathway: study by digital holographic microscopy

Astrocyte–neuron co-culture on microchips based on the model of SOD mutation to mimic ALS

Resistance to Diet-Induced Obesity and Associated Metabolic Perturbations in Haploinsufficient Monocarboxylate Transporter 1 Mice

Monocarboxylate Transporter 1 (Mct1) Is Critical For Regeneration In Peripheral Nerves

Estimation Of Glycolytic Rates Of Single Cells In Vivo

Inhibitory Avoidance Learning Is Associated With Altered Expression Of Genes Involved In Neuron-Glia Metabolic Coupling