Jacques Dubochet

Cette personne n’est plus à l’EPFL

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Publications associées (4)

Aggregation Behavior of Poly(ethylene glycol-bl-propylene sulfide) Di- and Triblock Copolymers in Aqueous Solution

Jacques Dubochet, Jeffrey Alan Hubbell, Conlin O'Neil

Block copolymers of poly(ethylene glycol)-bl-poly(propylene sulfide) (PEG-PPS) have recently emerged as a new macromolecular amphiphile capable of forming a wide range of morphologies when dispersed in water. To understand better the relationship between s ...

2009

Bending modes of DNA directly addressed by cryo-electron microscopy of DNA minicircles

John Maddocks, Jacques Dubochet, Andrzej Stasiak, Arnaud Amzallag, Davide Demurtas

We use cryo-electron microscopy (cryo-EM) to study the 3D shapes of 94-bp-long DNA minicircles and address the question of whether cyclization of such short DNA molecules necessitates the formation of sharp, localized kinks in DNA or whether the necessary ...

Oxford University Press2009

Switch-peptides: from conformational studies to Alzheimer's disease

Jacques Dubochet, Sonia Dos Santos, Karine Murat, Jérémy Bérard, Lydiane Jeanine Saucède, Richard Alan Mimna, Marie-Stéphanie Camus, Hilal Lashuel

A review. Studies on designed peptides that exhibit high tendencies for medium-induced conformational transitions have recently attracted much attention because structural changes are considered as mol. key processes in degenerative diseases. The exptl. ac ...

2006

Multifunctional Lipid/Quantum-Dots Hybrid Nanocontainers for Controlled Targeting of Live Cells

Pierre-Yves Bolinger, Horst Vogel, Jacques Dubochet, Gopakumar Gopalakrishnan, Paulina Izewska, Christophe Danelon, Davide Demurtas

In this communication, we report on an interesting observation of wide-ranging potential for cellular imaging and manipulation: Hydrophobic QDs can be easily incorporated into the bilayer membrane of lipid vesicles. Such lipid/QD nanocontainer hybrid vesic ...

Wiley-VCH Verlag GmbH2006

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