Publications de Loïck Moriggi

Carbazole as Linker for Dinuclear Gadolinium-Based MRI Contrast Agents

Loïck Moriggi, Lothar Helm, Anne-Sophie Chauvin, Bibimaryam Mousavi

Ligands able to complex two gadolinium ions have been synthesized and characterized in view of the ability of the complexes to increase the spin relaxation of water protons. All ligands are based on the heptadentate diethylenetriaminetetraacetic acid (DTTA ...

Wiley-V C H Verlag Gmbh2017

Complexation of [Gd(DTTA–Me)(H2O)2]− by Fluoride and Its Consequences to Water Exchange

Loïck Moriggi, Lothar Helm, Shima Karimi, Gail Ruth Hunter

The displacement of water molecule(s) from the inner coordination sphere of [Gd(DTTA–Me)(H2O)2]− (DTTA = ethylenetriamine-N,N,N″,N″-tetraacetate) by fluoride has been studied by multinuclear NMR relaxation (1H, 17O, 19F) and DFT calculations. Fluoride anio ...

American Chemical Society2016

Serum Albumin Targeted, pH-Dependent Magnetic Resonance Relaxation Agents

Loïck Moriggi, Lothar Helm

The objective of this work was the synthesis of serum albumin targeted, GdIII-based magnetic resonance imaging (MRI) contrast agents exhibiting a strong pH-dependent relaxivity. Two new complexes (Gd-glu and Gd-bbu) were synthesized based on the DO3A macro ...

2012

Gold Nanoparticles Functionalized with Gadolinium Chelates as High-Relaxivity MRI Contrast Agents

Loïck Moriggi, Lothar Helm

Functionalized nanoparticles (NPs) are presently under intensive study aimed at creating useful tools for molecular diagnosis, therapy, and biotechnology. ...

2009

A ruthenium-based metallostar: synthesis, sensitized luminescence and 1H relaxivity

Jean-Claude Bünzli, Loïck Moriggi, Lothar Helm, Alain Borel, Annina Aebischer

Ru-based metallostars Na4{Ru[Ln2bpy-DTTA2(H2O)4]3} (Ln = Y, Gd, and Eu) have been self-assembled in aqueous solution and their relaxivity and optical properties unravelled. The ynthesis and the purification of the new, highly stable heptametallic entities ...

2009

Highly efficient MRI contrast agents : from monomers to nanoparticles

Loïck Moriggi

Since contrasts agents are used in magnetic resonance imaging (MRI), numerous efforts have been done to increase their relaxivity (parameter allowing to quantify contrast agent efficiency). Few years ago, the Merbach group developed the chelating agent DTT ...

EPFL2008

Towards the Rational Design of MRI Contrast Agents: Electron Spin Relaxation Is Largely Unaffected by the Coordination Geometry of Gadolinium(III)-DOTA-Type Complexes

Loïck Moriggi, Lothar Helm, Alain Borel

Electron-spin relaxation is one of the determining factors in the efficacy of MRI contrast agents. Of all the parameters involved in determining relaxivity it remains the least well understood, particularly as it relates to the structure of the complex. On ...

2008

Physicochemical Properties of the High-Field MRI-Relevant [Gd(DTTA-Me)(H2O)2]− Complex

Loïck Moriggi, Lothar Helm, Cora Prestinari

To study the physicochemical properties of the DTTA chelating moiety (H4DTTA = diethylenetriaminetetraacetic acid = N,N′-[iminobis(ethane-2,1-diyl)]bis[N-(carboxymethyl)glycine]), used in several compounds proposed as magnetic resonance imaging (MRI) contr ...

2008

Physicochemical and MRI characterization of Gd3+-loaded polyamidoamine and hyperbranched dendrimers

André Merbach, Loïck Moriggi, Lothar Helm, Eva Jakab Toth

Springer, Springer-Verlag2007

Design of Gd(III)-Based Magnetic Resonance Imaging Contrast Agents: Static and Transient Zero-Field Splitting Contributions to the Electronic Relaxation and Their Impact on Relaxivity

André Merbach, Loïck Moriggi, Lothar Helm, Alain Borel

A multiple-frequency (9.4-325 GHz) and variable-temperature (276-320 K) electron paramagnetic resonance (EPR) study on low molecular weight gadolinium(III) complexes for potential use as magnetic resonance imaging (MRI) contrast agents has been performed. ...

2007