By binding growth factors (GFs), the ECM tightly regulates their activity. We recently reported that the heparin-binding domain II of fibronectin acts as a promiscuous high-affinity GF-binding domain. Here we hypothesized that fibrin, the provisional ECM d ...

National Academy of Sciences2013

Improving the osteogenic potential of BMP-2 with hyaluronic acid hydrogel modified with integrin-specific fibronectin fragment

Mikaël Martino, Jeffrey Alan Hubbell

While human bone morphogenetic protein-2 (rhBMP-2) is a promising growth factor for bone regeneration, its clinical efficacy has recently shown to be below expectation. In order to improve the clinical translation of rhBMP-2, there exists strong motivation ...

Elsevier2013

In situ cell manipulation through enzymatic hydrogel photopatterning

Matthias Lütolf, Mikaël Martino, Jeffrey Alan Hubbell, Katarzyna Mosiewicz, Martin Ehrbar, Laura Kolb

The physicochemical properties of hydrogels can be manipulated in both space and time through the controlled application of a light beam. However, methods for hydrogel photopatterning either fail to maintain the bioactivity of fragile proteins and are thus ...

Nature Publishing Group2013

Proangiogenic Hydrogels Within Macroporous Scaffolds Enhance Islet Engraftment in an Extrahepatic Site

Mikaël Martino, Jeffrey Alan Hubbell

The transplantation of allogeneic islets in recent clinical trials has shown substantial promise as a therapy for type 1 diabetes; however, long-term insulin independence remains inadequate. This has been largely attributed to the current intravascular, he ...

Mary Ann Liebert, Inc2013

Fibronectin Binding Modulates CXCL11 Activity and Facilitates Wound Healing

Mikaël Martino, Jeffrey Alan Hubbell, Priscilla Suhasna Maithili Briquez, Marco Pisano, Federico Tortelli

Engineered biomatrices offer the potential to recapitulate the regenerative microenvironment, with important implications in tissue repair. In this context, investigation of the molecular interactions occurring between growth factors, cytokines and extrace ...

Public Library of Science2013

The promotion of endothelial cell attachment and spreading using FNIII10 fused to VEGF-A(165)

Mikaël Martino, Jeffrey Alan Hubbell, Melody Swartz

Synergy in the downstream signaling pathways of the vascular endothelial growth factor receptor-2 (VEGFR-2) and the integrin alpha v beta 3 is critical for blood vessel formation. Thus, agents that activate both receptors could possess efficient pro-angiog ...

Elsevier2013

Engineering the Regenerative Microenvironment with Biomaterials

Mikaël Martino, Jeffrey Alan Hubbell, Priscilla Suhasna Maithili Briquez, Jeffrey James Rice, Federico Tortelli

Modern synthetic biomaterials are being designed to integrate bioactive ligands within hydrogel scaffolds for cells to respond and assimilate within the matrix. These advanced biomaterials are only beginning to be used to simulate the complex spatio-tempor ...

Wiley-Blackwell2013

Exploring the growth factor-binding properties of osteopontin

Mikaël Martino, Jeffrey Alan Hubbell, Federico Tortelli

Wiley-Blackwell2012

Dose- and time-dependent angiogenesis by controlled delivery of matrix-bound VEGF

Mikaël Martino, Jeffrey Alan Hubbell, Elena Groppa, Veronica Sacchi

Wiley-Blackwell2012

Engineering of Signaling Microenvironments with Fibronectin Domains to Enhance Tissue Regeneration

Mikaël Martino

Conducting tissue healing and regeneration through biomaterials and morphogens is still an unrealized goal. Understand the multiple roles of the extracellular matrix (ECM) is indeed essential for the design of successful regenerative medicine strategies. D ...

EPFL2011

Engineering the growth factor microenvironment with fibronectin domains to promote wound and bone tissue healing

Mikaël Martino, Jeffrey Alan Hubbell, Mayumi Mochizuki Martino, Federico Tortelli

Although growth factors naturally exert their morphogenetic influences within the context of the extracellular matrix microenvironment, the interactions among growth factors, their receptors, and other extracellular matrix components are typically ignored ...

2011

PPS nanoparticles as versatile delivery system to induce systemic and broad mucosal immunity after intranasal administration

Mikaël Martino, Jeffrey Alan Hubbell, Melody Swartz, Eleonora Simeoni, Armando Stano

Degradable polymer nanoparticles (NPs, 50nm) based on polypropylene sulfide (PPS) were conjugated to thiolated antigen and adjuvant proteins by reversible disulfide bonds and evaluated in mucosal vaccination. Ovalbumin was used as a model antigen, and anti ...

Elsevier2011

Biomimetic materials in tissue engineering

Mikaël Martino, Jeffrey Alan Hubbell, Jennifer Patterson

Biomaterial matrices are being developed that mimic the key characteristics of the extracellular matrix, including presenting adhesion sites and displaying growth factors in the context of a viscoelastic hydrogel. This review focuses on two classes of mate ...

Elsevier2010

Recombinant FGF-18 with a collagen II binding domain prevents cartilage degeneration in mice over five weeks after two intra-articular injections

Mikaël Martino, Jeffrey Alan Hubbell, Dominique André Rothenfluh

2009

Controlling integrin specificity and stem cell differentiation in 2D and 3D environments through regulation of fibronectin domain stability

Mikaël Martino, Jeffrey Alan Hubbell, Thomas Barker, Dominique André Rothenfluh, Mayumi Mochizuki Martino

The extracellular matrix (ECM) exerts powerful control over many cellular phenomena, including stem cell differentiation. As such, design and modulation of ECM analogs to ligate specific integrin is a promising approach to control cellular processes in vit ...

Elsevier2008

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