Publications de Philippe Colin

Glycan heterogeneity as a cause of the persistent fraction in HIV-1 neutralization

Philippe Colin, Aleksandar Antanasijevic

Neutralizing antibodies (NAbs) to multiple epitopes on the HIV-1-envelope glycoprotein (Env) have been isolated from infected persons. The potency of NAbs is measured more often than the size of the persistent fraction of infectivity at maximum neutralizat ...

Public Library Science2023

Gene therapy against amyotrophic lateral sclerosis: a bicistronic AAV vector for RNAi against mutated SOD1

Philippe Colin, Bernard Schneider, Aline Aebi, Pamela Solange Valdés Undurraga, Jean Philippe Gaudry

MARY ANN LIEBERT, INC2022

Anti-Aβ antibodies bound to neuritic plaques enhance microglia activity and mitigate tau pathology

Philippe Colin, Bernard Schneider, Vanessa Laversenne

The brain pathology of Alzheimer’s disease (AD) is characterized by the misfolding and aggregation of both the amyloid beta (Aβ) peptide and hyperphosphorylated forms of the tau protein. Initial Aβ deposition is considered to trigger a sequence of deleteri ...

2020

Nano-imaging trace elements at organelle levels in substantia nigra overexpressing alpha-synuclein to model Parkinson's disease

Philippe Colin, Bernard Schneider, Graham Knott

Sub-cellular trace element quantifications of nano-heterogeneities in brain tissues offer unprecedented ways to explore at elemental level the interplay between cellular compartments in neurodegenerative pathologies. We designed a quasi-correlative method ...

NATURE PUBLISHING GROUP2020

In vivo neurochemical measurements in cerebral tissues using a droplet-based monitoring system

Philippe Renaud, Arnaud Bertsch, Philippe Colin, Bernard Schneider, Guillaume Cédric Yves Petitpierre, Aurélien Thomas

Direct collection of extracellular fluid (ECF) plays a central role in the monitoring of neurological disorders. Current approaches using microdialysis catheters are however drastically limited in term of temporal resolution. Here we show a functional in v ...

Nature Publishing Group2017

Controlled release nanoparticle-embedded coatings reduce the tissue reaction to neuroprostheses

Philippe Renaud, Jeffrey Alan Hubbell, André Mercanzini, Philippe Colin, Jean-Charles Bensadoun, Sai Reddy

Controlled release coatings were developed for neuroprostheses with the aim of combating the tissue reaction following implantation in the brain. The coatings consist of poly(propylene sulfide) drug-eluting nanoparticles embedded in a poly(ethylene oxide) ...

Elsevier2010

in vivo Electrical Impedance Spectroscopy of Tissue Reaction to Microelectrode Arrays

Philippe Renaud, Arnaud Bertsch, André Mercanzini, Philippe Colin, Jean-Charles Bensadoun

The goal of this experiment was to determine the electrical properties of the tissue reaction to implanted microelectrode arrays. We describe a new method of analyzing electrical impedance spectroscopy data to determine the complex impedance of the tissue ...

2009

Demonstration of cortical recording using novel flexible polymer neural probes

Philippe Renaud, Arnaud Bertsch, Marc Jasper Boers, André Mercanzini, Philippe Colin, Jean-Charles Bensadoun, Karen Cheung

We present the fabrication, characterization, use in cortical recording and histological results of a flexible implantable neural probe. The microfabricated device is implemented in polyimide and platinum providing mechanical flexibility, high quality elec ...

2008

Demonstration of cortical recording and reduced inflammatory response using flexible polymer neural probes

Philippe Renaud, Arnaud Bertsch, Marc Jasper Boers, André Mercanzini, Philippe Colin, Jean-Charles Bensadoun, Karen Cheung

2007

Controlled Release Drug Coatings on Flexible Neural Probes

Philippe Renaud, Arnaud Bertsch, Jeffrey Alan Hubbell, André Mercanzini, Philippe Colin, Jean-Charles Bensadoun

We present the development, characterization and in vivo validation of a novel drug eluting coating that has been applied to flexible neural probes. The coating consists of drug eluting nanoparticles loaded with an anti-inflammatory drug embedded in a biod ...

2007