Publications de Damiano Banfi | EPFL Graph Search

A Label-Free, High-Throughput Phenotypic Screen Of Adipocytic Differentiation Modulators To Accelerate Hematopoietic Recovery

Gerardo Turcatti, Damiano Banfi, Bart Deplancke, Fabien Kuttler, Aurélien Laurent Jean-Charles Oggier, Pernille Yde Rainer, Vasco Ledebur de Antas de Campos, Vincent Roland Julien Gardeux

ELSEVIER SCIENCE INC2022

Highly Potent Host-Specific Small-Molecule Inhibitor of Paramyxovirus and Pneumovirus Replication with High Resistance Barrier

Gerardo Turcatti, Marc Chambon, Damiano Banfi, Jonathan Patrice Vesin

Multiple enveloped RNA viruses of the family Paramyxoviridae and Pneumoviridae, like measles virus (MeV), Nipah virus (NiV), canine distemper virus (CDV), or respiratory syncytial virus (RSV), are of high clinical relevance. Each year a huge number of live ...

AMER SOC MICROBIOLOGY2021

Image-Based Marker-Free Screening of GABA(A) Agonists, Antagonists, and Modulators

Gerardo Turcatti, Pierre Marquet, Damiano Banfi, Pascal Jourdain, Benjamin Rappaz, Fabien Kuttler

The ionotropic GABA(A) receptors represent the main target for different groups of widely used drugs having hypnotic and anxiolytic effects. So far, most approaches used to assess GABA activity involve invasive low -throughput electrophysiological techniqu ...

2019

Screening-based approach to discover effective platinum-based chemotherapies for cancers with poor prognosis

Gerardo Turcatti, Damiano Banfi, Paul Joseph Dyson, Fabien Kuttler, Hristo Plamenov Varbanov

Drug combinations are extensively used to treat cancer and are often selected according to complementary mechanisms. Here, we describe a cell-based high-throughput screening assay for identification of synergistic combinations between broadly applied plati ...

2019

Repositioning approved drugs for the treatment of problematic cancers using a screening approach

Gerardo Turcatti, Damiano Banfi, Paul Joseph Dyson, Fabien Kuttler, Hristo Plamenov Varbanov

Advances in treatment strategies together with an earlier diagnosis have considerably increased the average survival of cancer patients over the last four decades. Nevertheless, despite the growing number of new antineoplastic agents introduced each year, ...

2017

Telomerase Inhibitors from Cyanobacteria: Isolation and Synthesis of Sulfoquinovosyl Diacylglycerols from

Gerardo Turcatti, Damiano Banfi, Karl Gademann, Joachim Lingner, Laeticia Da Silva, Cyril Portmann, Emilie Baudat, Tom Woods

By using the Telospot assay, 27 different extracts of cyanobacteria were evaluated for telomerase inhibition. All extracts showed varying, but significant activity. We selected Microcystis aeruguinosa PCC 7806 to identify the active compound and a bioassay ...

Wiley-Blackwell2013

Leads for antitubercular compounds from kinase inhibitor library screens

Gerardo Turcatti, Marc Chambon, Damiano Banfi, Stewart Cole, Sophie Magnet, Ruben Hartkoorn, Edina Rita Székely

Discovering new drugs to treat tuberculosis more efficiently and to overcome multidrug resistance is a world health priority. To find antimycobacterial scaffolds, we screened a kinase inhibitor library of more than 12,000 compounds using an integrated stra ...

2010

www.nmrdb.org: Resurrecting and processing NMR spectra on-line

Damiano Banfi, Luc Patiny

NMR spectroscopy is certainly the analytical methodology that provides the most information about a molecule but the long-term vision of this information is often lacking. We present here two innovative tools accessible free from the web. NMR assigner allo ...

2008

Low- to high-throughput analysis of telomerase modulators with Telospot

Gerardo Turcatti, Marc Chambon, Damiano Banfi, Joachim Lingner

We designed a method termed Telospot to discover and characterize telomerase modulators as anticancer drugs or chemical biology tools. Telospot is based on a highly efficient human telomerase expression system and the detection of telomerase DNA reaction p ...

2007

Dynamic combinatorial libraries in protein mimicry applying the template assembled synthetic protein concept

Damiano Banfi

EPFL2003