Publications de Simone Cavadini

Structural mechanism of cGAS inhibition by the nucleosome

Rudolf Hovius, Simone Cavadini, Beat Fierz, Andrea Ablasser, Sélène-Véronique Glück, Baptiste Claude André Guey, Alexiane Clara Decout, Kristina Makasheva, Pauline Ambre Melenec

The DNA sensor cGAS initiates innate immune responses following microbial infection, cellular stress, and cancer1. Upon activation by double-stranded DNA, cytosolic cGAS produces 2’3’ cyclic GMP-AMP and triggers inflammatory cytokine and type I interferon ...

2020

Micelles for delivery of nitric oxide

Nikolaos Stergiopoulos, Jeffrey Alan Hubbell, Simone Cavadini, Yun Suk Jo, Jay Gantz, Tyler Nerton Thacher, Davide Demurtas

We designed block copolymer pro-amphiphiles and amphiphiles for providing very long-term release of nitric oxide (NO). A block copolymer of N-acryloylmorpholine (AM, as a hydrophile) and N-acryloyl-2,5-dimethylpiperazine (AZd, as a hydrophilic precursor) w ...

2009

Indirect detection of nitrogen-14 in solid-state NMR spectroscopy

Simone Cavadini

This thesis describes new methods for the detection of 14N nuclei by solid-state nuclear magnetic resonance. So far, the low natural abundance (0.4 %) 15N isotope has been widely used to study nitrogen-containing samples because of its spin-1/2 nature. The ...

EPFL2009

Coherence transfer between spy nuclei and nitrogen-14 in solids

Geoffrey Bodenhausen, Simone Cavadini

Coherence transfer from ‘spy nuclei’ such as 1H or 13C (S = 1/2) was used to excite single- or double-quantum coherences of 14N nuclei (I = 1) while the S spins were aligned along the static field, in the manner of heteronuclear single-quantum correlation ...

Academic Press Inc - Elsevier Science2008

Evidence for Dynamics on a 100 ns Time Scale from Single- and Double-Quantum Nitrogen-14 NMR in Solid Peptides

Geoffrey Bodenhausen, Simone Cavadini, Simone Ulzega

The indirect detection of 14N spectra via protons in the manner of heteronuclear multiple-quantum correlation (HMQC) allows one to obtain single- (SQ) and double-quantum (DQ) 14N spectra in solids. A comparison of the SQ and DQ line widths as a function of ...

2008

Singlet states open the way to longer time-scales in the measurement of diffusion by NMR spectroscopy

Simone Cavadini, Paul Romeo Vasos

Nuclear magnetic resonance is a powerful nonintrusive technique for measuring diffusion coefficients through the use of pulsed field gradients. The main limitation to the application range of this method is imposed by the relaxation time constants of the m ...

2008

Indirect Detection of Nitrogen-14 in Solid-State NMR Spectroscopy

Geoffrey Bodenhausen, Simone Cavadini

2007

Proton-Detected Nitrogen-14 NMR by Recoupling of Heteronuclear Dipolar Interactions using Symmetry-Based Sequences

Geoffrey Bodenhausen, Simone Cavadini

Elsevier2007

Indirect Detection of Nitrogen-14 NMR in Solids via Protons by Nuclear Magnetic Resonance Spectroscopy

Geoffrey Bodenhausen, Simone Cavadini

Academic Press Inc - Elsevier Science2006

Nitrogen-14 NMR Spectroscopy using Residual Dipolar Splittings in Solids

Geoffrey Bodenhausen, Simone Cavadini

2006

Slow Diffusion by Singlet State NMR Spectroscopy

Geoffrey Bodenhausen, Simone Cavadini

Small diffusion coeffs. can be measured by using populations of singlet states that have a relaxation time const., Ts, which can be much longer than the longitudinal relaxation time, T1. Spatial information can be encoded with pulsed field gradients in the ...

2005