Publications de Karine Murat | EPFL Graph Search

Switch-peptides as folding precursors in self-assembling peptides and amyloid fibrillogenesis

Karine Murat, Jérémy Bérard, Richard Alan Mimna, Marie-Stéphanie Camus, Hilal Lashuel, Adrian Schmid

The study of conformational transitions of peptides has obtained considerable attention recently because of their importance as a mol. key event in a variety of degenerative diseases. However, the study of peptide self-assembly into beta-sheets and amyloid ...

2007

Switch-peptides: from conformational studies to Alzheimer's disease

Jacques Dubochet, Sonia Dos Santos, Karine Murat, Jérémy Bérard, Lydiane Jeanine Saucède, Richard Alan Mimna, Marie-Stéphanie Camus, Hilal Lashuel

A review. Studies on designed peptides that exhibit high tendencies for medium-induced conformational transitions have recently attracted much attention because structural changes are considered as mol. key processes in degenerative diseases. The exptl. ac ...

2006

Switch-peptides as folding precursors in amyloid fibrillogenesis

Sonia Dos Santos, Karine Murat, Jérémy Bérard, Lydiane Jeanine Saucède, Richard Alan Mimna, Marie-Stéphanie Camus

Intramol. O,N-acyl migration reactions were used as structural switch (S-elements) from a depsipeptide bond contg., unfolded state (Soff) to an all-amide, native states (Son). Chem. or enzymically triggered acyl migrations allowed for the controlled induct ...

2006

Le concept switch-peptides : le potentiel de la migration S,N acylique dans l'induction de l'activité biologique et la rupture de structures secondaires in situ

Karine Murat

Conformational transitions have found broad interest due to their impact on protein misfolding and self-assembly as key events leading to the development of neurodegenerative diseases. However, investigation of these dynamic events has been limited so far ...

EPFL2006

Switch on amyloid beta peptide self-assembly by enzyme-triggered acyl migration

Sonia Dos Santos, Karine Murat, Lydiane Jeanine Saucède, Richard Alan Mimna, Marie-Stéphanie Camus

2005

Switch-peptides: Controlling self-assembly of amyloid beta-derived peptides in vitro by consecutive triggering of acyl migrations

Sonia Dos Santos, Karine Murat, Lydiane Jeanine Saucède, Richard Alan Mimna

2005