Publications de Jean-Louis Bény

Ultrafast Ca2+ wave in cultured vascular smooth muscle cells aligned on a micropatterned surface

Jean-Jacques Meister, Jean-Louis Bény, Jairo Camilo Quijano Perez, Benoît Vianay

Communication between vascular smooth muscle cells (SMCs) allows control of their contraction and so regulation of blood flow. The contractile state of SMCs is regulated by cytosolic Ca2+ concentration (Ca2+) which propagates as Ca2+ waves over a sign ...

Elsevier2013

Intercellular calcium waves in primary cultured rat mesenteric smooth muscle cells are mediated by Connexin43

Jean-Jacques Meister, Jean-Louis Bény, Nadia Halidi

Intercellular Ca2+ wave propagation between vascular smooth muscle cells (SMCs) is associated with the propagation of contraction along the vessel. Here, we characterize the involvement of gap junctions (GJs) in Ca2+ wave propagation between SMCs at the ce ...

2012

Identification and functional response of interstitial Cajal-like cells from rat mesenteric artery

Jean-Jacques Meister, Jean-Louis Bény, Aurélie Formey de Saint Louvent, Lara Buscemi Estefanell

Cells with irregular shapes, numerous long thin filaments, and morphological similarities to the gastrointestinal interstitial cells of Cajal (ICCs) have been observed in the wall of some blood vessels. These ICC-like cells (ICC-LCs) do not correspond to t ...

Springer-Verlag2011

Propagation of fast and slow intercellular Ca2+ waves in primary cultured arterial smooth muscle cells

Jean-Jacques Meister, Jean-Louis Bény, Nadia Halidi

Smooth muscle contraction is regulated by changes in cytosolic Ca2+ concentration (Ca2+). In response to stimulation, Ca2+ increase in a single cell can propagate to neighbouring cells through gap junctions, as intercellular Ca2+ waves. To investigate ...

2011

Intercellular calcium waves are associated with the propagation of vasomotion along arterial strips

Jean-Jacques Meister, Dominique Seppey, Jean-Louis Bény, Michèle Koenigsberger, Roger Sauser

Vasomotion consists of cyclic arterial diameter variations induced by synchronous contractions and relaxations of smooth muscle cells. However, the arteries do not contract simultaneously on macroscopic distances, and a propagation of the contraction can b ...

2010

Mechanisms of Propagation of Intercellular Calcium Waves in Arterial Smooth Muscle Cells

Jean-Jacques Meister, Dominique Seppey, Jean-Louis Bény, Michèle Koenigsberger

In rat mesenteric arteries, smooth muscle cells exhibit intercellular calcium waves in response to local phenylephrine stimulation. These waves have a velocity of similar to 20 cells/s and a range of similar to 80 cells. We analyze these waves in a theoret ...

Elsevier2010

Calcium dynamics and vasomotion in arteries subject to isometric, isobaric, and isotonic conditions

Jean-Jacques Meister, Dominique Seppey, Jean-Louis Bény, Michèle Koenigsberger, Roger Sauser

In vitro, different techniques are used to study the smooth muscle cells' calcium dynamics and contraction/relaxation mechanisms on arteries. Most experimental studies use either an isometric or an isobaric setup. However, in vivo, a blood vessel is neithe ...

2008

Does the Endothelium Abolish or Promote Arterial Vasomotion in Rat Mesenteric Arteries? Explanations for the Seemingly Contradictory Effects

Jean-Jacques Meister, Dominique Seppey, Jean-Louis Bény, Michèle Koenigsberger, Roger Sauser

Karger2008

Role of myoendothelial communication on arterial vasomotion

Jean-Louis Bény, Michèle Koenigsberger, Roger Sauser

2006

Stretch-elicited calcium responses in the intact mouse thoracic aorta

Jean-Jacques Meister, Jean-Louis Bény

Stretch-elicited intracellular calcium (Ca(2+)) changes in individual smooth muscle cells in a ring of aorta were measured simultaneously with the force developed by the ring. A phasic increase in Ca(2+) was observed in 30% of the cells and a sus ...

Elsevier2006

Effects of arterial wall stress on vasomotion

Jean-Jacques Meister, Jean-Louis Bény, Michèle Koenigsberger, Roger Sauser

Smooth muscle and endothelial cells in the arterial wall are exposed to mechanical stress. Indeed blood flow induces intraluminal pressure variations and shear stress. An increase in pressure may induce a vessel contraction, a phenomenon known as the myoge ...

Elsevier2006

Evidence for signaling via gap junctions from smooth muscle to endothelial cells in rat mesenteric arteries: possible implication of a second messenger

Jean-Jacques Meister, Philippe Pittet, Mathieu Lamboley, Jean-Louis Bény, Michèle Koenigsberger, Roger Sauser

We investigated heterocellular communication in rat mesenteric arterial strips at the cellular level using confocal microscopy. To visualize Ca(2+) changes in different cell populations, smooth muscle cells (SMCs) were loaded with Fluo-4 and endothelial ce ...

Elsevier2005