Publications de Paolo Angelino

Orb5: A global electromagnetic gyrokinetic code using the PIC approach in toroidal geometry

Stephan Brunner, Laurent Villard, Alberto Bottino, Sébastien Jolliet, Paolo Angelino, Thibaut Vernay, Ben McMillan, Emmanuel Lanti, Julien Stanislas Pierre Dominski, Noé Thomas Elie Ohana, Aaron Lewis Scheinberg, Claudio Gheller

This paper presents the current state of the global gyrokinetic code Orb5 as an update of the previous reference (Jolliet et al., 2007). The Orb5 code solves the electromagnetic Vlasov–Maxwell system of equations using a PIC scheme and also includes collis ...

2019

Analysis of NGS-based blood immune cell RNA signatures for colorectal cancer detection

Stephan Morgenthaler, Paolo Angelino, Sahar Hosseinian Ehrensberger, Helen Lindsay

OXFORD UNIV PRESS2019

Mutant CTNNB1 and histological heterogeneity define metabolic subtypes of hepatoblastoma

Paolo Angelino, Olivier Michielin, Mauro Delorenzi, Etienne Meylan, Jessica Christine Vazquez, Stefania Crippa, Pierre-Benoit Bernard Ancey

Hepatoblastoma is the most common malignant pediatric liver cancer. Histological evaluation of tumor biopsies is used to distinguish among the different subtypes of hepatoblastoma, with fetal and embryonal representing the two main epithelial components. W ...

2017

RIP4 inhibits STAT3 signaling to sustain lung adenocarcinoma differentiation

Paolo Angelino, Mauro Delorenzi, Nadine Fournier, Etienne Meylan, Johanna Pauline Chiffelle, Jawahar Kopparam, Alessandra Piersigilli

Loss of epithelial differentiation and extracellular matrix (ECM) remodeling are known to facilitate cancer progression and are associated with poor prognosis in patients with lung cancer. We have identified Receptor-interacting serine/threonine protein ki ...

Nature Publishing Group2017

A method for analysis and design of metabolism using metabolomics data and kinetic models: Application on lipidomics using a novel kinetic model of sphingolipid metabolism

Paolo Angelino, Vassily Hatzimanikatis, Howard Riezman, Georgios Savoglidis

We present a model-based method, designated Inverse Metabolic Control Analysis (IMCA), which can be used in conjunction with classical Metabolic Control Analysis for the analysis and design of cellular metabolism. We demonstrate the capabilities of the met ...

Academic Press Inc Elsevier Science2016

The consensus molecular subtypes of colorectal cancer

Paolo Angelino, Mauro Delorenzi, Douglas Hanahan, Anguraj Sadanandam, Krisztian Homicsko, Sarah Gerster, Xin Wang

Colorectal cancer (CRC) is a frequently lethal disease with heterogeneous outcomes and drug responses. To resolve inconsistencies among the reported gene expression-based CRC classifications and facilitate clinical translation, we formed an international c ...

Nature Publishing Group2015

Global Gyrokinetic ITG Turbulence Simulations of ITER

Stephan Brunner, Trach-Minh Tran, Laurent Villard, Alberto Bottino, Sébastien Jolliet, Paolo Angelino, Thibaut Vernay, Ben McMillan

Global gyrokinetic simulations of ion temperature gradient (ITG) driven turbulence in an ideal MHD ITER equilibrium plasma are performed with the ORB5 code. The noise control and field-aligned Fourier filtering procedures implemented in ORB5 are essential ...

Institute of Physics2013

Recent TCV results – innovative plasma shaping to improve plasma properties and insight

Stephan Brunner, Basil Duval, Timothy Goodman, Jean-Marc Moret, Antoine Pochelon, Olivier Sauter, Laurent Villard, Holger Reimerdes, Stefano Coda, Alberto Bottino, Sébastien Jolliet, Jonathan Rossel, Alexander Karpushov, Laurie Porte, Paolo Angelino, Benoît Labit, Alessandro Marinoni, Mikael Rancic, Andreas Pitzschke, Dávid Wágner, David Nicholas Wagner

2012

Parallel filtering in global gyrokinetic simulations

Stephan Brunner, Trach-Minh Tran, Laurent Villard, Alberto Bottino, Sébastien Jolliet, Paolo Angelino, Thibaut Vernay, Ben McMillan

In this work, a Fourier solver [B.F. McMillan, S. Jolliet, A. Bottino, P. Angelino, T.M. Tran, L Villard, Comp. Phys. Commun. 181 (2010) 7151 is implemented in the global Eulerian gyrokinetic code GT5D [Y. Idomura, H. Urano, N. Aiba, S. Tokuda, Nucl. Fusio ...

Elsevier2012

Predictions on heat transport and plasma rotation from global gyrokinetic simulations

Trach-Minh Tran, Laurent Villard, Alberto Bottino, Sébastien Jolliet, Paolo Angelino, Ben McMillan

Flux-driven global gyrokinetic codes are now mature enough to make predictions in terms of turbulence and transport in tokamak plasmas. Some of the recent breakthroughs of three such codes, namely GYSELA, ORB5 and XGC1, are reported and compared wherever a ...

IOP Publishing Ltd2011

Rapid Fourier space solution of linear partial differential equations in toroidal magnetic confinement geometries

Trach-Minh Tran, Laurent Villard, Alberto Bottino, Sébastien Jolliet, Paolo Angelino, Ben McMillan

Fluctuating quantities in magnetic confinement geometries often inherit a strong anisotropy along the field lines. One technique for describing these structures is the use of a certain set of Fourier components on the tori of nested flux surfaces. We descr ...

Elsevier2009

Avalanche-like bursts in global gyrokinetic simulations

Trach-Minh Tran, Laurent Villard, Alberto Bottino, Sébastien Jolliet, Paolo Angelino, Ben McMillan

Highly variable flux surface averaged heat fluxes are resolved in gyrokinetic simulations of ion temperature gradient (ITG) turbulence, even in large systems. Radially propagating fronts or avalanches are also seen. Their propagation lengths in gyroradii a ...

American Institute of Physics (AIP)2009

The role of plasma elongation on turbulent transport in magnetically confined plasmas

Trach-Minh Tran, Laurent Villard, Alberto Bottino, Sébastien Jolliet, Paolo Angelino, Ben McMillan

The theoretical study of plasma turbulence is of central importance to fusion research. Experimental evidence indicates that the confinement time results mainly from the turbulent transport of energy, the magnitude of which depends on the turbulent state r ...

American Physical Society2009

Quasi-steady and steady states in global gyrokinetic particle-in-cell simulations

Laurent Villard, Alberto Bottino, Sébastien Jolliet, Paolo Angelino, Thibaut Vernay, Ben McMillan

Collisionless delta-f gyrokinetic particle-in-cell simulations suffer from the entropy paradox, in which the entropy grows linearly in time while low-order moments are saturated. As a consequence, these simulations do not reach a steady state and are unsui ...

American Institute of Physics (AIP)2009

A comprehensive gyrokinetic description of global electrostatic microinstabilities in a tokamak

Stephan Brunner, Laurent Villard, Paolo Angelino

It is believed that low frequency microinstabilities such as ion temperature gradient (ITG) driven modes and trapped electron modes (TEMs) are largely responsible for the experimentally observed anomalous transport via the ion and electron channels in a to ...

American Institute of Physics (AIP)2009

Influence of the parallel nonlinearity on zonal flows and heat transport in global gyrokinetic particle-in-cell simulations

Laurent Villard, Alberto Bottino, Sébastien Jolliet, Paolo Angelino, Thibaut Vernay, Ben McMillan

In this paper, the influence of the parallel nonlinearity on zonal flows and heat transport in global particle-in-cell ion-temperature-gradient simulations is studied. Although this term is in theory orders of magnitude smaller than the others, several aut ...

American Institute of Physics (AIP)2009

The role of plasma elongation on the linear damping of zonal flows

Trach-Minh Tran, Laurent Villard, Alberto Bottino, Sébastien Jolliet, Paolo Angelino, Ben McMillan

American Institute of Physics (AIP)2008

Role of nonadiabatic untrapped electrons in global electrostatic ion temperature gradient driven modes in a tokamak

Stephan Brunner, Laurent Villard, Paolo Angelino

In this work, role of nonadiabatic untrapped electrons in the context of a global ion temperature gradient driven mode has been investigated. In past studies, untrapped electrons have been assumed to be able to respond "instantaneously" to a disturbance. I ...

American Institute of Physics2008

Long global gyrokinetic simulations: Source terms and particle noise control

Trach-Minh Tran, Laurent Villard, Alberto Bottino, Sébastien Jolliet, Paolo Angelino, Ben McMillan

In global gyrokinetic simulations it takes a long time for the turbulence to reach a quasisteady state, and quantitative predictions about the quasisteady state turbulence have been difficult to obtain computationally. In particular, global particle-in-cel ...

American Institute of Physics2008

The European turbulence code benchmarking effort: turbulence driven by thermal gradients in magnetically confined plasmas

Sébastien Jolliet, Paolo Angelino, Ben McMillan

2008