Publications de Richard Alan Mimna

Switch-peptides as folding precursors in self-assembling peptides and amyloid fibrillogenesis

Karine Murat, Jérémy Bérard, Richard Alan Mimna, Marie-Stéphanie Camus, Hilal Lashuel, Adrian Schmid

The study of conformational transitions of peptides has obtained considerable attention recently because of their importance as a mol. key event in a variety of degenerative diseases. However, the study of peptide self-assembly into beta-sheets and amyloid ...

2007

Toward the design of highly efficient, readily accessible peptide N-caps for the induction of helical conformations

Richard Alan Mimna

A series of novel peptide N-caps was designed with an emphasis on ease of synthesis and an abundance of hydrogen bond acceptors. Different scaffolds based on sugars, cyclic hydrocarbons, and amino acids are developed with a variety of hydrogen bond accepto ...

Kluwer Academic Publishers, Springer2007

Disruption of amyloid-derived peptide assemblies through the controlled induction of a beta-sheet to alpha-helix transformation: application of the switch concept

Richard Alan Mimna, Marie-Stéphanie Camus, Hilal Lashuel, Adrian Schmid

Reversal of amyloid formation through a controlled induced transformation from beta-sheet to sol. alpha-helix structures through the use of a switch element S could have an important consequences understanding the mechanisms of amyloid formation and cleara ...

Wiley-VCH Verlag GmbH2007

Switch-peptides as folding precursors in amyloid fibrillogenesis

Sonia Dos Santos, Karine Murat, Jérémy Bérard, Lydiane Jeanine Saucède, Richard Alan Mimna, Marie-Stéphanie Camus

Intramol. O,N-acyl migration reactions were used as structural switch (S-elements) from a depsipeptide bond contg., unfolded state (Soff) to an all-amide, native states (Son). Chem. or enzymically triggered acyl migrations allowed for the controlled induct ...

2006

Switch-peptides: from conformational studies to Alzheimer's disease

Jacques Dubochet, Sonia Dos Santos, Karine Murat, Jérémy Bérard, Lydiane Jeanine Saucède, Richard Alan Mimna, Marie-Stéphanie Camus, Hilal Lashuel

A review. Studies on designed peptides that exhibit high tendencies for medium-induced conformational transitions have recently attracted much attention because structural changes are considered as mol. key processes in degenerative diseases. The exptl. ac ...

2006

Switch peptides : in situ nucleation of conformational transitions relevant to protein misfolding diseases

Richard Alan Mimna

Aspects of conformational transitions, folding, and misfolding of peptides and proteins have recently taken center stage in various domains at the interface of chemistry, biology, and medicine because of their impact on protein misfolding diseases. Due to ...

EPFL2005

Switch-peptides: Controlling self-assembly of amyloid beta-derived peptides in vitro by consecutive triggering of acyl migrations

Sonia Dos Santos, Karine Murat, Lydiane Jeanine Saucède, Richard Alan Mimna

2005

Switch on amyloid beta peptide self-assembly by enzyme-triggered acyl migration

Sonia Dos Santos, Karine Murat, Lydiane Jeanine Saucède, Richard Alan Mimna, Marie-Stéphanie Camus

2005