Publications de Gilad Silberberg

Reconstruction and Simulation of Neocortical Microcircuitry

Nenad Buncic, Jean-Vincent Le Bé, Selim Arsever, Henry Markram, Gilad Silberberg, Sébastien Lasserre, Vincent Delattre, Raphael Dumusc, Rodrigo de Campos Perin, Imad Riachi, Thomas Berger, Felix Schürmann, James Gonzalo King, Rajnish Ranjan, Srikanth Ramaswamy, Michael Lee Hines, Sean Lewis Hill, Juan Bautista Hernando Vieites, Georges Khazen, Shruti Muralidhar, Anastasia Ailamaki, Eilif Benjamin Muller, Farhan Tauheed, Jean Pierre Ghobril, Julie Meystre, Daniel Keller, Idan Segev, Michael Reimann, Thomas Heinis, John Richard Walker, Martin Telefont, Yun Wang, Ying Shi, Joseph William Graham, Marwan Muhammad Ahmed Abdellah, Julian Charles Shillcock, Jean-Denis Georges Emile Courcol, Ahmet Bilgili, Werner Alfons Hilda Van Geit, Athanassia Chalimourda, , , , , , , , , , , , , , , , , , , , , , , , , , , ,

Brief Bursts Self-Inhibit and Correlate the Pyramidal Network

Henry Markram, Gilad Silberberg, Rodrigo de Campos Perin, Thomas Berger

Inhibitory pathways are an essential component in the function of the neocortical microcircuitry. Despite the relatively small fraction of inhibitory neurons in the neocortex, these neurons are strongly activated due to their high connectivity rate and the ...

Public Library of Science2010

Multiquantal release underlies the distribution of synaptic efficacies in the neocortex

Henry Markram, Gilad Silberberg, Daniela Helbig

Inter-pyramidal synaptic connections are characterized by a wide range of EPSP amplitudes. Although repeatedly observed at different brain regions and across layers, little is known about the synaptic characteristics that contribute to this wide range. In ...

2009

Frequency-dependent disynaptic inhibition in the pyramidal network: a ubiquitous pathway in the developing rat neocortex

Henry Markram, Gilad Silberberg, Rodrigo de Campos Perin, Thomas Berger

The general structure of the mammalian neocortex is remarkably similar across different cortical areas. Despite certain cytoarchitectural specializations and deviations from the general blueprint, the principal organization of the neocortex is relatively u ...

2009

Slow oscillations in neural networks with facilitating synapses

Henry Markram, Gilad Silberberg

The synchronous oscillatory activity characterizing many neurons in a network is often considered to be a mechanism for representing, binding, conveying, and organizing information. A number of models have been proposed to explain high-frequency oscillatio ...

Springer US2008

Disynaptic inhibition between neocortical pyramidal cells mediated by Martinotti cells

Henry Markram, Gilad Silberberg

Reliable activation of inhibitory pathways is essential for maintaining the balance between excitation and inhibition during cortical activity. Little is known, however, about the activation of these pathways at the level of the local neocortical microcirc ...

2007

Hyperconnectivity of Local Neocortical Microcircuitry Induced by Prenatal Exposure to Valproic Acid

Tania Rinaldi, Henry Markram, Gilad Silberberg

Exposure to valproic acid (VPA) during embryogenesis can cause several teratogenic effects, including developmental delays and in particular autism in humans if exposure occurs during the third week of gestation. We examined the postnatal effects of embryo ...

Oxford University Press2007

Morphological, electrophysiological, and synaptic properties of corticocallosal pyramidal cells in the neonatal rat neocortex

Jean-Vincent Le Bé, Henry Markram, Gilad Silberberg, Yi Wang

Neocortical pyramidal cells (PCs) project to various cortical and subcortical targets. In layer V, the population of thick tufted PCs (TTCs) projects to subcortical targets such as the tectum, brainstem, and spinal cord. Another population of layer V PCs p ...

Oxford University Press2007

The neocortical microcircuit as a tabula rasa

Henry Markram, Gilad Silberberg

The neocortex has a high capacity for plasticity. To understand the full scope of this capacity, it is essential to know how neurons choose particular partners to form synaptic connections. By using multineuron whole-cell recordings and confocal microscopy ...

National Academy of Sciences2005

Microcircuits in action--from CPGs to neocortex

Henry Markram, Gilad Silberberg

To understand the interface between global brain function and molecular neuroscience--that is, the microcircuit level--a major challenge. Such understanding is prerequisite if we are to account for neural function in cellular terms. Very few vertebrate mic ...

2005

Synaptic pathways in neural microcircuits

Henry Markram, Gilad Silberberg

The functions performed by different neural microcircuits depend on the anatomical and physiological properties of the various synaptic pathways connecting neurons. Neural microcircuits across various species and brain regions are similar in terms of their ...

2005

The Neocortical Microcircuit Database (NMDB)

Henry Markram, Gilad Silberberg

Wiley Press2005

Short-term-plasticity orchestrates the response of pyramidal cells and interneurons to population bursts

Wulfram Gerstner, Henry Markram, Gilad Silberberg

The synaptic drive from neuronal populations varies considerably over short time scales. Such changes in the presynaptic rate trigger many temporal processes absent under steady-state conditions. This paper examines the differential impact of pyramidal cel ...

2005

Subthreshold cross-correlations between cortical neurons: A reference model with static synapses

Wulfram Gerstner, Henry Markram, Gilad Silberberg

The structure of cross-correlations between subthreshold potentials of neocortical neurons was recently examined. Characteristic features included broad widths and significant peak advances. It was suggested that dynamic synapses shape these cross-correlat ...

Elsevier2005