Publications de Chiara Perazzolo

Occurrence and fate of micropollutants in the Vidy Bay of Lake Geneva, part I: Priority list for environmental risk assessment of pharmaceuticals

Pharmaceuticals are substances designed to have a biological effect in humans. Their presence in the environment, especially in surface waters, is of increasing concern because of their potential risk to non-target species. A large number of pharmaceutical ...

Society of Environmental Toxicology and Chemistry Press2010

Occurrence and fate of micropollutants in the Vidy Bay of Lake Geneva, part II: Micropollutant removal between wastewater and raw drinking water

Frédéric Bonvin, Luiz Felippe De Alencastro, Dominique Grandjean, Chiara Perazzolo, Florence Bonvin, Tamar Kohn

The occurrence and removal of 58 pharmaceuticals, endocrine disruptors, corrosion inhibitors, biocides, and pesticides, were assessed in the wastewater treatment plant (WWTP) of the city of Lausanne, Switzerland, as well as in the effluent-receiving water ...

Society of Environmental Toxicology and Chemistry Press2010

Hyperpolarized Lithium-6 as a Sensor of Nanomolar Contrast Agents

Arnaud Comment, Jacques Van Der Klink, Chiara Perazzolo, Rolf Gruetter, Sami Jannin, Ruud van Heeswijk, Fiodar Kurdzesau, Cristina Ramona Cudalbu

Lithium is widely used in psychotherapy. The Li-6 isotope has a long intrinsic longitudinal relaxation time T-1 on the order of minutes, making it an ideal candidate for hyperpolarization experiments. In the present study we demonstrated that lithium-6 can ...

Wiley-Blackwell2009

In vivo H-1 NMR measurement of glycine in rat brain at 9.4 T at short echo time

Chiara Perazzolo, Rolf Gruetter, Giulio Gambarota, Lijing Xin

Glycine is an amino acid present in mammalian brain, where it acts as an inhibitory and excitatory neurotransmitter. The two detectable protons of glycine give rise to a singlet at 3.55 ppm that overlaps with the more intense myo-inositol resonances, and i ...

Wiley-Blackwell2008

In Vivo Detection of Hyperpolarized 15N Choline in the Rat

Arnaud Comment, Chiara Perazzolo, Rolf Gruetter, Sami Jannin, Ruud van Heeswijk, Fiodar Kurdzesau, Cristina Ramona Cudalbu

2008

Evidence of Chemical Exchange in Recombinant Major Urinary Protein and Quenching Thereof Upon Pheromone Binding

Geoffrey Bodenhausen, Chiara Perazzolo, Mariachiara Verde

Kluwer Academic Publishers, Springer2007

Internal motions in biomolecules studied by NMR spectroscopy : an application to major urinary protein-1 and its complex with 2-methoxy-3-isobutylpyrazine

Chiara Perazzolo

Since many biological processes occur on the μs to ms time scale, internal dynamics on that time scale is believed to be related to biological functionality. The characterization of internal dynamics is thus an important issue to improve our understanding ...

EPFL2006

Slow motions in nondeuterated proteins: Concerted chemical shift modulations of backbone nuclei

Geoffrey Bodenhausen, Julien Wist, Chiara Perazzolo

Springer, Springer-Verlag2005

Effects of Protein-pheromone Complexation on Correlated Chemical Shift Modulations

Geoffrey Bodenhausen, Julien Wist, Chiara Perazzolo

Major urinary protein (MUP) is a pheromone-carrying protein of the lipocalin family. Previous studies by isothermal titrn. calorimetry (ITC) show that the affinity of MUP for the pheromone 2-methoxy-3-isobutylpyrazine (IBMP) is mainly driven by enthalpy, w ...

Kluwer Academic Publishers, Springer2005