Publications de Christophe Boss

In vivo transcriptomic profiling using cell encapsulation identifies effector pathways of systemic aging

Nicolas Bouche, Christophe Boss, Patrick Descombes, Filippo De Franceschi, Sylviane Métairon, Jérome Feige, Omid Mashinchian

Sustained exposure to a young systemic environment rejuvenates aged organisms and promotes cellular function. However, due to the intrinsic complexity of tissues it remains challenging to pinpoint niche-independent effects of circulating factors on specifi ...

2022

Pancreatic beta cell based optical biosensor and system for continuous glucose monitoring

Catherine Dehollain, Nicolas Bouche, Christophe Boss, Umberto De Marchi, Bakul Jitendra Vinchhi, Ninad Dilip Agashe

A bio-electronics system that measures cytosolic [Ca2+] in vitro in the INS-1E pancreatic beta-cells using a 430 nm excitation light with the excitation wavelength of the probe being at 435 nm was successfully implemented and tested. We transfected the INS ...

IEEE2019

Optical pancreatic beta cell based biosensor, applications and glucose monitoring

Catherine Dehollain, Nicolas Bouche, Christophe Boss, Umberto De Marchi, Bakul Jitendra Vinchhi

An optical pancreatic beta-cell based biosensor for measuring cytosolic [Ca2+] is presented in this work. An in vitro bio-electronic system is built for testing various applications and characterizing features of the biosensor. A panoply of applications su ...

IEEE2019

Encapsulation of Insulin-Secreting Cells Expressing a Genetically Encoded Fluorescent Calcium Indicator for Cell-Based Sensing In Vivo

Nicolas Bouche, Christophe Boss, Andreas Wiederkehr, Mouna Conrad, Umberto De Marchi, Federico Sizzano

The development of cell-based biosensors that give insight into cell and tissue function in vivo is an attractive technology for biomedical research. Here, the development of a cell line expressing a fluorescent calcium sensor for the study of beta-cell fu ...

Wiley2017

Size-selective diffusion in nanoporous alumina membranes for a glucose affinity sensor

Jean-Michel Sallese, Peter Ryser, Eric Meurville, Christophe Boss

The retention, diffusion and structural properties of 2–4 nm nanoporous alumina membranes were investigated in view of their integration as size-selective interface in a glucose sensor. These membranes exhibit remarkable glucose diffusion properties with o ...

Elsevier2012

A Viscosity-Dependent Affinity Sensor for Continous Monitoring of Glucose in Biological Fluids

Christophe Boss

For fifty years, tremendous efforts have been directed towards the development of glucose sensors for tight glycemic control of diabetic patients. Today, millions of diabetics test their blood glucose level daily, making glucose the most commonly tested an ...

EPFL2012

A viscosity-dependent affinity sensor for continuous monitoring of glucose in biological fluids

Jean-Michel Sallese, Peter Ryser, Eric Meurville, Christophe Boss

We present a viscometric affinity biosensor for continuous monitoring of glucose in biological fluids such as blood and plasma. The sensing principle of this chemico-mechanical sensor is based upon the viscosity variation of a sensitive fluid with glucose ...

Elsevier2011

MULTI-ANALYTE DETECTION FOR BIOLOGICAL FLUIDS Towards Continous Monitoring of Glucose, Ionized Calcium and pH using a Viscometric Affinity Biosensor

Peter Ryser, Eric Meurville, Christophe Boss, Pablo Dosil Rosende, Frédéric Schmitt

We present a viscometric affinity biosensor that can potentially allow continuous multi-analyte monitoring in biological fluids like blood or plasma. The sensing principle is based on the detection of viscosity changes of a polymeric solution which has a s ...

SciTePress2011

Experimental characterization of the distribution of collagen fiber recruitment

Nikolaos Stergiopoulos, Christophe Boss, Sylvain Roy

The passive biomechanical behavior of blood vessels is generally modeled by a parallel arrangement of elastin and collagen, with collagen recruitment depending on vessel strain. We experimentally determined the collagen recruitment distribution using confo ...

2010

Novel chemico-mechanical approach towards long-term implantable glucose sensing

Jean-Michel Sallese, Peter Ryser, Eric Meurville, Christophe Boss

The proof of concept of a continuously sensing affinity device based on the glucose-dependent viscosity of a sensitive solution containing dextran and Concanavalin A has been successfully demonstrated. The biosensor incorporates a piezoelectric diaphragm a ...

Elsevier2009