Publications de Ariane Rochat | EPFL Graph Search

Low temperature and mTOR inhibition favor human epidermal stem cell maintenance

Juan Ramon Mosig, Fahd Azzabi Zouraq, Kai Johnsson, Yann Barrandon, Ariane Rochat, Thomas Michael Braschler, Johannes Alexander Mosig, Jean-Baptiste Bureau

ELSEVIER SCIENCE INC2023

Low temperature and mTOR inhibition favor stem cell maintenance in human keratinocyte cultures

Fahd Azzabi Zouraq, Kai Johnsson, Yann Barrandon, Ariane Rochat, Thomas Michael Braschler, Johannes Alexander Mosig, Jean-Baptiste Bureau, Mako Kamiya

Adult autologous human epidermal stem cells can be extensively expanded ex vivo for cell and gene therapy. Identifying the mechanisms involved in stem cell maintenance and defining culture conditions to maintain stemness is critical, because an inadequate ...

WILEY2023

Traceable Impedance-Based Dispensing and Cloning of Living Single Cells

Philippe Renaud, Yann Barrandon, Stéphanie Claudinot, Ariane Rochat, David Vincent Bonzon, Georges Muller

Single-cell cloning is essential in stem cell biology, cancer research, and biotechnology. Regulatory agencies now require an indisputable proof of clonality that current technologies do not readily provide. Here, we report a one-step cloning method using ...

2020

Tp63-expressing adult epithelial stem cells cross lineages boundaries revealing latent hairy skin competence

Yann Barrandon, Stéphanie Claudinot, Paola Bonfanti, Ariane Rochat, Daniel-Alexandre Littman, Christèle Gonneau

The formation of hair follicles, a landmark of mammals, requires complex mesenchymal-epithelial interactions and it is commonly believed that embryonic epidermal cells are the only cells that can respond to hair follicle morphogenetic signals in vivo. Here ...

Nature Research2020

Pore Size Manipulation in 3D Printed Cryogels Enables Selective Cell Seeding

Philippe Renaud, Arnaud Bertsch, Ariane Rochat, Thomas Michael Braschler, Ludovic Serex, Amélie Barbara Hildegarde Béduer, Aleksandra Filippova

Cryogels are macroporous materials that display remarkable properties, such as high pore interconnection, large surface to volume ratio, and high mechanical stability, making them good candidates for 3D cell culture. However, shaping cryogels remains chall ...

Wiley2018

Capturing epidermal stemness for regenerative medicine

Yann Barrandon, Stéphanie Claudinot, Ariane Rochat, Nicolas Grasset, Stéphanie Danièle Hélène Droz-Georget, Andrea Zaffalon, François Gorostidi

The skin is privileged because several skin-derived stem cells (epithelial stem cells from epidermis and its appendages, mesenchymal stem cells from dermis and subcutis, melanocyte stem cells) can be efficiently captured for therapeutic use. Main indicatio ...

Academic Press Ltd- Elsevier Science Ltd2012

Location of corneal epithelial stem cells Reply

Georges Abou Jaoudé, Yann Barrandon, Ariane Rochat

2010

The role of LEKTI in fate determination of keratinocyte stem cells

Ariane Rochat, Alessandro Wataru Amici

2010

A Single Cell Approach for Safe Gene Therapy

Yann Barrandon, Ariane Rochat, Graham Knott, Alessandra Recchia

Mary Ann Liebert2009

Oligopotent stem cells are distributed throughout the mammalian ocular surface

Georges Abou Jaoudé, Yann Barrandon, Ariane Rochat

The integrity of the cornea, the most anterior part of the eye, is indispensable for vision. Forty- five million individuals worldwide are bilaterally blind and another 135 million have severely impaired vision in both eyes because of loss of corneal trans ...

2008