Publications de François Lazeyras

Allogenic Bioengineered Cartilage Achieves Hyaline Cartilage Repair in a Large Animal Model: A Promising Step Forward

François Lazeyras, Sébastien Courvoisier

Background: Chondrocyte-based cell therapy remains a promising method for cartilage repair, despite limitations faced during the last 30 years. Purpose/Hypothesis: This work presents hyaline-like bioengineered beads from donor chondrocytes as a novel treat ...

2025

MRI characterization of in vitro clots at 3T and 7T: A technical note

François Lazeyras, Lijing Xin

In acute ischemic stroke, the composition of the occlusive clot can be associated with the underlying pathophysiology and the response to treatment. For these reasons, it is important to characterize the clot composition from clinical scans. We examine the ...

Masson Editeur2024

Choreography Controlled (ChoCo) brain MRI artifact generation for labeled motion-corrupted datasets

Bastien Chopard, Michel Kocher, François Lazeyras, Sébastien Courvoisier, Julien Songeon

MRI is a non-invasive medical imaging modality that is sensitive to patient motion, which constitutes a major limitation in most clinical applications. Solutions may arise from the reduction of acquisition times or from motion-correction techniques, either ...

ELSEVIER SCI LTD2022

In vivo magnetic resonance P-31-Spectral Analysis With Neural Networks: 31P-SPAWNN

François Lazeyras, Sébastien Courvoisier, Lijing Xin, Julien Songeon

Purpose: We have introduced an artificial intelligence framework, 31P-SPAWNN, in order to fully analyze phosphorus-31 (P-31) magnetic resonance spectra. The flexibility and speed of the technique rival traditional least-square fitting methods, with the per ...

WILEY2022

The relationship between EEG and fMRI connectomes is reproducible across simultaneous EEG-fMRI studies from 1.5T to 7T

François Lazeyras, Rolf Gruetter, João Pedro Forjaco Jorge, Giannina Rita Iannotti, Arwen Blanche Giraud

Both electroencephalography (EEG) and functional Magnetic Resonance Imaging (fMRI) are non-invasive methods that show complementary aspects of human brain activity. Despite measuring different proxies of brain activity, both the measured blood-oxygenation ...

2021

Shedding light on excessive crying in babies

Dimitri Nestor Alice Van De Ville, François Lazeyras, Lorena Gonçalves de Alcântara e Freitas Krikler

Background Excessive and inconsolable crying behavior in otherwise healthy infants (a condition called infant colic (IC)) is very distressing to parents, may lead to maternal depression, and in extreme cases, may result in shaken baby syndrome. Despite the ...

NATURE PUBLISHING GROUP2021

Music enhances structural maturation of emotional processing neural pathways in very preterm infants

Nicolas Kunz, François Lazeyras, Laura Ioana Gui

Prematurity disrupts brain maturation by exposing the developing brain to different noxious stimuli present in the neonatal intensive care unit (NICU) and depriving it from meaningful sensory inputs during a critical period of brain development, leading to ...

2020

Music processing in preterm and full-term newborns: A psychophysiological interaction (PPI) approach in neonatal fMRI

Dimitri Nestor Alice Van De Ville, François Lazeyras, Serafeim Loukas

Neonatal Intensive Care Units (NICU) provide special equipment designed to give life support for the increasing number of prematurely born infants and assure their survival. More recently NICU's strive to include developmentally oriented care and modulate ...

2019

Cerebral Gray and White Matter Involvement in Anorexia Nervosa Evaluated by T1, T2, and T2*Mapping

François Lazeyras, Tobias Kober, Nurten Ceren Askin

BACKGROUND AND PURPOSE Changes in the brain composition of anorexics could potentially be expected, opening the door to new imaging approaches where quantitative and qualitative MRI have a role. Our purpose was to investigate anorexia-related brain dehydra ...

WILEY2019

Music in premature infants enhances high-level cognitive brain networks

Djalel Eddine Meskaldji, Dimitri Nestor Alice Van De Ville, François Lazeyras

Neonatal intensive care units are willing to apply environmental enrichment via music for preterm newborns. However, no evidence of an effect of music on preterm brain development has been reported to date. Using resting-state fMRI, we characterized a circ ...

National Academy of Sciences2019

Fast high-resolution brain metabolite mapping on a clinical 3T MRI by accelerated H-1-FID-MRSI and low-rank constrained reconstruction

Michel Kocher, Dimitri Nestor Alice Van De Ville, François Lazeyras, Sébastien Courvoisier, Matthieu Guerquin-Kern, Jeffrey Adam Kasten

Purpose: Epitomizing the advantages of ultra short echo time and no chemical shift displacement error, high-resolution-free induction decay magnetic resonance spectroscopic imaging (FID-MRSI) sequences have proven to be highly effective in providing unbias ...

WILEY2019

MP2RAGE and Susceptibility-Weighted Imaging in Lesional Epilepsy at 7T

François Lazeyras, Lijing Xin, Maxime Olivier Baud, João Pedro Forjaco Jorge, Giannina Rita Iannotti

BACKGROUND AND PURPOSE: Surgery is the first choice therapeutic approach in case of drug-resistant epilepsy. Unfortunately, up to 43% of patients referred for presurgical assessment do not have a lesion detectable by routine 3T magnetic resonance imaging ( ...

2018

Resting-State Networks of Adolescents Experiencing Depersonalization-Like Illusions: Cross-sectional and Longitudinal Findings

Dimitri Nestor Alice Van De Ville, François Lazeyras

The mirror-gazing task (MGT) experimentally induces illusions, ranging from simple color changes in the specular image of oneself, to depersonalization-like anomalous self-experiences (ASE) as in experiencing one's specular image as someone else. The objec ...

OXFORD UNIV PRESS2018

Clinical Neuroimaging Using 7 T MRI: Challenges and Prospects

François Lazeyras, Rolf Gruetter, Lijing Xin, Özlem Ipek, Pascal Martelli

The aim of this article is to illustrate the principal challenges, from the medical and technical point of view, associated with the use of ultrahigh field (UHF) scanners in the clinical setting and to present available solutions to circumvent these limita ...

2018

Evaluating anorexia-related brain atrophy using MP2RAGE-based morphometry

François Lazeyras, Bénédicte Marie Maréchal, Tobias Kober, Alexis Roche

To evaluate brain atrophy in anorexic patients by automated cerebral segmentation with the magnetization-prepared 2 rapid acquisition gradient echo (MP2RAGE) MRI sequence. Twenty patients (female; mean age, 27.9 years), presenting consecutively for brain M ...

Springer2017

Brain network characterization of high-risk preterm-born school-age children

Jean-Philippe Thiran, François Lazeyras, Alessandra Griffa, Elda Fischi Gomez

Higher risk for long-term cognitive and behavioral impairments is one of the hallmarks of extreme prematurity (EP) and pregnancy-associated fetal adverse conditions such as intrauterine growth restriction (IUGR). While neurodevelopmental delay and abnormal ...

Elsevier Sci Ltd2016

3D-Printed Shepp-Logan Phantom as a Real-World Benchmark for MRI

Dimitri Nestor Alice Van De Ville, François Lazeyras, Jeffrey Adam Kasten

Purpose: As prescribed and reliable geometrical entities, phantoms have served as indispensable validation tools in a variety of MR-related topics. Though a number of phantoms have been conceived, certain applications may warrant highly customized geometri ...

Wiley-Blackwell2016

Magnetic resonance spectroscopic imaging at superresolution: Overview and perspectives

Dimitri Nestor Alice Van De Ville, François Lazeyras, Jeffrey Adam Kasten

The notion of non-invasive, high-resolution spatial mapping of metabolite concentrations has long enticed the medical community. While magnetic resonance spectroscopic imaging (MRSI) is capable of achieving the requisite spatio-spectral localization, it ha ...

Academic Press Inc - Elsevier Science2016

Presurgical brain mapping in epilepsy using simultaneous EEG and functional MRI at ultra-high field: feasibility and first results

François Lazeyras, Wietske Van der Zwaag, João Pedro Forjaco Jorge, Giannina Rita Iannotti

OBJECTIVES: The aim of this study was to demonstrate that eloquent cortex and epileptic-related hemodynamic changes can be safely and reliably detected using simultaneous electroencephalography (EEG)-functional magnetic resonance imaging (fMRI) recordings ...

Springer Verlag2016

Structural Brain Connectivity in School-Age Preterm Infants Provides Evidence for Impaired Networks Relevant for Higher Order Cognitive Skills and Social Cognition

Jean-Philippe Thiran, Djalel Eddine Meskaldji, Patric Hagmann, François Lazeyras, Elda Fischi Gomez

Extreme prematurity and pregnancy conditions leading to intrauterine growth restriction (IUGR) affect thousands of newborns every year and increase their risk for poor higher order cognitive and social skills at school age. However, little is known about t ...

Oxford University Press2015