Publications de Roger Sauser | EPFL Graph Search

Intercellular calcium waves are associated with the propagation of vasomotion along arterial strips

Jean-Jacques Meister, Dominique Seppey, Jean-Louis Bény, Michèle Koenigsberger, Roger Sauser

Vasomotion consists of cyclic arterial diameter variations induced by synchronous contractions and relaxations of smooth muscle cells. However, the arteries do not contract simultaneously on macroscopic distances, and a propagation of the contraction can b ...

2010

Force transmission in migrating cells

Jean-Jacques Meister, Alexander Verkhovskiy, Roger Sauser, Maxime Fred Maurice Fournier

During cell migration, forces generated by the actin cytoskeleton are transmitted through adhesion complexes to the substrate. To investigate the mechanism of force generation and transmission, we analyzed the relationship between actin network velocity an ...

Rockefeller University Press2010

Calcium dynamics and vasomotion in arteries subject to isometric, isobaric, and isotonic conditions

Jean-Jacques Meister, Dominique Seppey, Jean-Louis Bény, Michèle Koenigsberger, Roger Sauser

In vitro, different techniques are used to study the smooth muscle cells' calcium dynamics and contraction/relaxation mechanisms on arteries. Most experimental studies use either an isometric or an isobaric setup. However, in vivo, a blood vessel is neithe ...

2008

Does the Endothelium Abolish or Promote Arterial Vasomotion in Rat Mesenteric Arteries? Explanations for the Seemingly Contradictory Effects

Jean-Jacques Meister, Dominique Seppey, Jean-Louis Bény, Michèle Koenigsberger, Roger Sauser

Karger2008

Effects of arterial wall stress on vasomotion

Jean-Jacques Meister, Jean-Louis Bény, Michèle Koenigsberger, Roger Sauser

Smooth muscle and endothelial cells in the arterial wall are exposed to mechanical stress. Indeed blood flow induces intraluminal pressure variations and shear stress. An increase in pressure may induce a vessel contraction, a phenomenon known as the myoge ...

Elsevier2006

Role of myoendothelial communication on arterial vasomotion

Jean-Louis Bény, Michèle Koenigsberger, Roger Sauser

2006

Emergent properties of electrically coupled smooth muscle cells

Jean-Jacques Meister, Michèle Koenigsberger, Roger Sauser

Asynchronous and synchronous calcium oscillations occur in a variety of cells. A well-established pathway for intercellular communication is provided by gap junctions which connect adjacent cells and can mediate electrical and chemical coupling. Several ex ...

Springer-Verlag2005

Evidence for signaling via gap junctions from smooth muscle to endothelial cells in rat mesenteric arteries: possible implication of a second messenger

Jean-Jacques Meister, Philippe Pittet, Mathieu Lamboley, Jean-Louis Bény, Michèle Koenigsberger, Roger Sauser

We investigated heterocellular communication in rat mesenteric arterial strips at the cellular level using confocal microscopy. To visualize Ca(2+) changes in different cell populations, smooth muscle cells (SMCs) were loaded with Fluo-4 and endothelial ce ...

Elsevier2005