Publications de Jean-Yves Chatton

Molecular insights into sex-specific metabolic alterations in Alzheimer’s mouse brain using multi-omics approach

Nicolas Jean Philippe Guex, Jean-Yves Chatton, Maxime Jan

2023

Extracellular Potassium and Glutamate Interact To Modulate Mitochondria in Astrocytes

Sylvain Eric Lengacher, Jean-Yves Chatton

2018

Sodium Signaling and Astrocyte Energy Metabolism

The Na+ gradient across the plasma membrane is constantly exploited by astrocytes as a secondary energy source to regulate the intracellular and extracellular milieu, and discard waste products. One of the most prominent roles of astrocytes in the brain is ...

Wiley-Blackwell2016

Control of Mitochondrial pH by Uncoupling Protein 4 in Astrocytes Promotes Neuronal Survival

Sylvain Eric Lengacher, Pierre Magistretti, Jean-Yves Chatton, Hélène Danielle Perreten Lambert, Manuel Raphael Zenger

Brain activity is energetically costly and requires a steady and highly regulated flow of energy equivalents between neural cells. It is believed that a substantial share of cerebral glucose, the major source of energy of the brain, will preferentially be ...

American Society for Biochemistry and Molecular Biology2014

Glutamate transport decreases mitochondrial pH and modulates oxidative metabolism in astrocytes

Sylvain Eric Lengacher, Jean-Yves Chatton, Hélène Danielle Perreten Lambert

During synaptic activity, the clearance of neuronally released glutamate leads to an intracellular sodium concentration increase in astrocytes that is associated with significant metabolic cost. The proximity of mitochondria at glutamate uptake sites in as ...

2011

Spontaneous $ Na ^{ + } $ Transients in Individual Mitochondria of Intact Astrocytes

Michaël Unser, Dimitri Nestor Alice Van De Ville, Jean-Yves Chatton

Mitochondria in intact cells maintain low

Na ^{ + }

levels despite the large electrochemical gradient favoring cation influx into the matrix. In addition, they display individual spontaneous transient depolarizations. We report here that individual mit ...

Wiley-Liss2008

Glucose and lactate are equally effective in energizing activity-dependent synaptic vesicle turnover in purified cortical neurons

Pierre Magistretti, Jean-Yves Chatton

This study examines the role of glucose and lactate as energy substrates to sustain synaptic vesicle cycling. Synaptic vesicle turnover was assessed in a quantitative manner by fluorescence microscopy in primary cultures of mouse cortical neurons. An elect ...

Elsevier2006