Publications de Carine Delattre-Gubelmann

ZFP30 promotes adipogenesis through the KAP1-mediated activation of a retrotransposon-derived Pparg2 enhancer

Carine Delattre-Gubelmann, Didier Trono, Julien Léonard Duc, Bart Deplancke, Sunil Kumar Raghav, Marco Cassano, Michaël Imbeault, Petra Catalina Schwalie, Suk Min Jang, Riccardo Dainese, Julie Marie Russeil, Wanze Chen, Evgeniia Pankevich

Krüppel-associated box zinc finger proteins (KZFPs) constitute the largest family of mammalian transcription factors, but most remain completely uncharacterized. While initially proposed to primarily repress transposable elements, recent reports have revea ...

Nature Research2019

Development and application of experimental tools to elucidate the gene regulatory network underlying adipogenesis

Carine Delattre-Gubelmann

Excess fat mass in obese individuals, which is characterized by an increase of white adipocyte cell size and number, significantly raises the risk of developing metabolic syndrome symptoms as well as cancer. A detailed understanding of the transcriptional ...

EPFL2013

A yeast one-hybrid and microfluidics-based pipeline to map mammalian gene regulatory networks

Jovan Simicevic, Carine Delattre-Gubelmann, Jean-Daniel Feuz, Antonina Iagovitina, Bart Deplancke, Alina Isakova, Sunil Kumar Raghav, Sebastian Martin Waszak

The comprehensive mapping of gene promoters and enhancers has significantly improved our understanding of how the mammalian regulatory genome is organized. An important challenge is to elucidate how these regulatory elements contribute to gene expression b ...

Nature / European Molecular Biology Organization2013

Global and stage specific patterns of krüppel-associated-box zinc finger protein gene expression in murine early embryonic cells

Carine Delattre-Gubelmann, Didier Trono, Andrea Corsinotti, Helen Mary Rowe, Adamantia Kapopoulou, Bart Deplancke, Yoann Mouscaz, Michaël Imbeault

Highly coordinated transcription networks orchestrate the self-renewal of pluripotent stem cell and the earliest steps of mammalian development. KRAB-containing zinc finger proteins represent the largest group of transcription factors encoded by the genome ...

Public Library of Science2013

GETPrime: a gene- or transcript-specific primer database for quantitative real-time PCR

Carine Delattre-Gubelmann, Bart Deplancke, Jacques Rougemont, Alexandre Gattiker, Fabrice David, Andreas Massouras, Frederik Decouttere

The vast majority of genes in humans and other organisms undergo alternative splicing, yet the biological function of splice variants is still very poorly understood in large part because of the lack of simple tools that can map the expression profiles and ...

2011

Primer-initiated sequence synthesis to detect and assemble structural variants

Carine Delattre-Gubelmann, Stewart Cole, Swapna Uplekar, Bart Deplancke, Jacques Rougemont, Andreas Massouras, Frederik Decouttere

Nature Publishing Group2010