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Wee Han Ang

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Publications associées (42)

Mass spectrometric analysis of ubiquitin-platinum interactions of leading anticancer drugs: MALDI versus ESI

Paul Joseph Dyson, Wee Han Ang, Christian Hartinger, Angela Casini

The protein binding of anticancer metallodrugs is regarded as an important part in their mode of action both for delivering the active moiety into the tumor but also being responsible for deactivation and/or unwanted side effects. Characterization of prote ...

2007

Development of nitrile-functionalized ionic liquids for C-C coupling reactions: implication of carbene and nanoparticle catalysts

Rosario Scopelliti, Paul Joseph Dyson, Dongbin Zhao, Zhaofu Fei, Wee Han Ang, Cinzia Chiappe

A series of nitrile-functionalized imidazolium salts (many of which are liquid at room temperature) have been prepared. The reactivity of these salts with PdCl2 has been studied, resulting in salts containing a tetrachloropalladate dianion or co ...

2007

Novel strategies for overcoming drug resistance in transition metal-based anticancer compounds

Wee Han Ang

Cisplatin is one of the most important and widely used anticancer drug in clinical use. However, its effectiveness is limited by its high toxicity and incidence of drug resistance. This has provided motivation for the search for transition metal-based drug ...

EPFL2007

Strategy To Tether Organometallic Ruthenium-Arene Anticancer Compounds to Recombinant Human Serum Albumin

Paul Joseph Dyson, Elisa Daldini, Wee Han Ang

In order to utilize macromols. for drug targeting and delivery, a strategy to tether organometallic ruthenium-arene drugs to carrier protein mols. was developed. The approach involves the design of a drug fragment capable of conjugating to linker mols. on ...

2007

Investigation into the formation of heteronuclear clusters of formula [ Ru6C(CO)16Ag2X 2]2- (X = Cl, Br or I)

Rosario Scopelliti, Paul Joseph Dyson, Wee Han Ang

Reaction of [Ru6C(CO)16]2− with an excess of AgX (X = Cl, Br or I) affords heteronuclear clusters of formula [{Ru6C(CO)16Ag2X}2]2− in 80% yield, which for X = I and X = ...

2007

Application of N,N-bis(diphenylphosphino)aniline palladium(II) complexes as pre-catalysts in Heck coupling reactions

Paul Joseph Dyson, Wee Han Ang

Palladium(II) complexes with N,N-bis(diphenylphosphino)aniline ligands catalyze the Heck reaction between styrene and aryl bromides, affording stilbenes in good yield. The structures of two of the complexes used as pre-catalysts have been detd. by single-c ...

2007

Thiocyanate functionalised ionic liquids: synthesis, characterisation and reactivity

Rosario Scopelliti, Paul Joseph Dyson, Dongbin Zhao, Zhaofu Fei, Wee Han Ang

The reaction of chloromethyl thiocyanate with 1-methylimidazole affords the imidazolium salt, 1-thiocyanomethyl-3-methylimidazolium chloride, [C1SCNmim]Cl (1a). Exchange of the chloride anion in 1a by [PF6] ...

2007

Development of Ruthenium Antitumor Drugs that Overcome Multidrug Resistance Mechanisms

Rosario Scopelliti, Paul Joseph Dyson, Claudine Scolaro, Wee Han Ang, Andrew Douglas Phillips, Gianni Sava

Organometallic ruthenium(II) complexes of the general formula [Ru(η6-p-cymene)Cl2(L)] and [Ru(η6-p-cymene)Cl(L)2][BPh4] with modified phenoxazine- and anthracene-based multidrug resistanc ...

2007

Remarkable Anticancer Activity of Triruthenium-Arene Clusters Compared to Tetraruthenium-Arene Clusters

Paul Joseph Dyson, Wee Han Ang

The in vitro activity of a series of ruthenium clusters, [(η6-C6H6)(η6-C6Me6)2Ru3(μ-H)3(μ3-O)][BF4], [(η6-C6H6)(η6-1,4-iPrC6H4Me)(η6-C6Me6)Ru3(μ-H)3(μ3-O)][BF4], [(η6-C6H6)4Ru4(μ-H)4][BF4]2, [(η6-C6H5Me)4Ru4(μ-H)4][BF4]2 and [(η6-C6H6)4Ru4(μ-H)3(μ-OH)][Cl] ...

Springer US2007

ESI-MS characterisation of protein adducts of anticancer ruthenium(II)-arene PTA (RAPTA) complexes

Paul Joseph Dyson, Wee Han Ang, Angela Casini

Electrospray ionization mass spectrometry allows a rapid characterization of the adducts formed between three novel anticancer ruthenium(II)-arene PTA compds. and horse heart cytochrome c or hen egg white lysozyme. Specific information on the nature of the ...

2007

Organometallic ruthenium inhibitors of glutathione-S-transferase P1-1 as anticancer drugs

Paul Joseph Dyson, Wee Han Ang

Ruthenium-arene complexes conjugated to ethacrynic acid were prepared as part of a strategy to develop novel glutathione-S-transferase (GST) inhibitors with alternate modes of activity through the organometallic fragment, ultimately to provide targeted rut ...

Wiley-Blackwell2007

Development of organometallic ruthenium(II) anticancer (RAPTA) drugs

Wee Han Ang

A review. The systematic development of the RAPTA family of organometallic ruthenium(II) anticancer drugs contg. a monodentate 1,3,5-triaza-7-phosphatricyclo-[3.3.1.1]decane ligand and a h6-arene ligand is described. ...

2007

Revisiting Ether-Derivatized Imidazolium-Based Ionic Liquids

Rosario Scopelliti, Paul Joseph Dyson, Dongbin Zhao, Zhaofu Fei, Wee Han Ang

A series of ether-derivatized imidazolium halides have been prepd. and characterized. Contrary to literature reports, they are all cryst. solids and have m.ps. well above room temp. (50-100 °C). Single crystals of the imidazolium salts, obtained in situ by ...

2007

A strategy for the synthesis of transition-metal nanoparticles and their transfer between liquid phases

Paul Joseph Dyson, Dongbin Zhao, Zhaofu Fei, Wee Han Ang

Nanoparticles can be stabilized by an ionic liq. polymer (ILP) composed of imidazolium units incorporating a hydrophobic benzyl group. The resulting gold, platinum, and palladium nanoparticles can be efficiently transferred from water to ionic liqs. by exc ...

2006

In Vitro Evaluation of Rhodium and Osmium RAPTA Analogues: The Case for Organometallic Anticancer Drugs Not Based on Ruthenium

Gabor Laurenczy, Paul Joseph Dyson, Antoine Dorcier, Wee Han Ang, Andrew Douglas Phillips

Reaction of the dimer [(η5-C5Me5)RhCl(μ2-Cl)]2 with 2 or 4 equiv of the water-soluble phosphine 1,3,5-triaza-7-phosphatricyclo[3.3.1.1]decane (pta) affords [Rh(η5-C5Me< ...

2006

Ionic solid-state dimers and polymers derived from imidazolium dicarboxylic acids

Rosario Scopelliti, Paul Joseph Dyson, Zhaofu Fei, Wee Han Ang

A series of imidazolium dicarboxylic acids have been prepd. from the reaction of the 1,3-bis(carboxymethyl)imidazolium zwitterion with the Bronsted acids HX (X = F, Br, Cl, ClO4). The structures of these acids have been established in the solid ...

2006

Complexation associated rearrangement of iminobiphosphines to diphosphinoamines

Rosario Scopelliti, Paul Joseph Dyson, Dongbin Zhao, Zhaofu Fei, Wee Han Ang

The reaction of the iminobiphosphines RN[dbnd]>PPh2-PPh2, where R = C6H4(p-CN), C6H4(m-CN), C6H4(o-C6H5), C6F5 or C6

2006

Development of Organometallic Ruthenium-Arene Anticancer Drugs That Resist Hydrolysis

Rosario Scopelliti, Paul Joseph Dyson, Elisa Daldini, Claudine Scolaro, Wee Han Ang

With a view to develop drugs that could resist hydrolysis in aq. media,organometallic arene-capped ruthenium(II) 1,3,5-triaza-7-phosphatricyclo[3.3.1.1]decane (RAPTA) complexes bearing chelating carboxylate ligands have been prepd. and studied. The new com ...

2006

Classical and Non-Classical Ruthenium-Based Anticancer Drugs: Towards Targeted Chemotherapy

Paul Joseph Dyson, Wee Han Ang

Ruthenium-based anticancer chemotherapies are making significant advances in clinical trials. Until recently, the focus has been on coordination complexes, and mechanisms such as "activation by reduction" and "transferrin-targeted delivery" have been propo ...

2006

A Supercooled Imidazolium Iodide Ionic Liquid as a Low-Viscosity Electrolyte for Dye-Sensitized Solar Cells

Michael Graetzel, Shaik Mohammed Zakeeruddin, Paul Joseph Dyson, Dongbin Zhao, Zhaofu Fei, Wee Han Ang

A series of allyl-functionalized imidazolium salts are reported, including 1-allyl-3-ethylimidazolium iodide and 1-allyl-3-propylimidazolium iodide, which have m.ps. close to room temp. and show typical properties of supercooled fluids if heated above thei ...

2006

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