Publications de Markus Scholl | EPFL Graph Search

Potential novel drug carriers for inner ear treatment: hyperbranched polylysine and lipid nanocapsules

Harm-Anton Klok, Markus Scholl, Zuzana Kadlecova

Aim: Treatment of sensorineural hearing loss could be advanced using novel drug carriers such as hyperbranched polylysine (HBPL) or lipid nanocapsules (LNCs). This study examined HBPL and LNCs for their cellular uptake and possible toxicity in vitro and in ...

Future Medicine2009

Dendritic and hyperbranched polyamides

Harm-Anton Klok, Markus Scholl, Zuzana Kadlecova

This article discusses the synthesis and properties of dendritic and hyperbranched polyamides. The first part of the article focuses on peptide dendrimers and starts with providing an overview of the synthetic pathways that have been used to prepare dendri ...

2009

The thermal polymerization of amino acids revisited; Synthesis and structural characterization of hyperbranched polymers from L-lysine

Harm-Anton Klok, Markus Scholl

This contribution reports on the synthesis of hyperbranched polylysines via thermal polymerization of L-lysine hydrochloride. Polymerization of L-lysine hydrochloride in the presence of one equivalent KOH at 150°C resulted in polymers with a number-average ...

2007

Controlling polymer architecture in the thermal hyperbranched polymerization of L-lysine

Harm-Anton Klok, Markus Scholl

Because of the unequal reactivity of the two amine groups of L-lysine hydrochloride, thermal polymerization of this asymmetrical AB2 monomer results in hyperbranched polymers, which contain ?2.5 times more N?-linked linear compared to N?-linked linear stru ...

American Chemical Society2007

Synthesis, structural characterization and applications of hyperbranched polymers based on L-lysine

Markus Scholl

L-lysine is an essential a-amino acid and a necessary building block for all proteins in the body. As an essential amino acid, L-lysine is not synthesized by humans or animals. Industrially produced L-lysine has therefore a big market as food additive, e.g ...

EPFL2007

Thermotropic ionic liquid crystals via self-assembly of cationic hyperbranched polypeptides and anionic surfactants

Harm-Anton Klok, Markus Scholl

This work describes the dilute solution and solid-state structure of polyelectrolyte complexes generated from hyperbranched polylysine (HBPL) and various anionic, sodium alkyl sulfate surfactants. In dilute solution, the radius of gyration (Rg) of the HBPL ...

American Chemical Society2007

Nonspherical assemblies generated from polystyrene-b-poly(L-lysine) polyelectrolyte block copolymers

Jutta Christine Wandrey, Laurent Bourdillon, Harm-Anton Klok, Harald Nuhn, Markus Scholl

This report describes the aqueous solution self-assembly of a series of polystyrenem-b-poly(L-lysine)n block copolymers (m = 8-10; n = 10-70). The polymers are prepared by ring-opening polymerization of e-benzyloxycarbonyl-L-lysine AT-carboxyanhydride usin ...

2005