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Peter Frey

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Publications associées (42)

In-vivo performance of high-density collagen gel tubes for urethral regeneration in a rabbit model

Lionel Ambroise Micol, Jeffrey Alan Hubbell, Peter Frey

Congenital malformations or injuries of the urethra can be treated using existing autologous tissue, but these procedures are sometimes associated with severe complications. Therefore, tissue engineering may be advantageous for generating urethral grafts. ...

Elsevier2012

Single cell analysis of porcine and human urothelial cells

Jeffrey Alan Hubbell, Yann Barrandon, Peter Frey, Hans Mattias Larsson, François Gorostidi

Wiley-Blackwell2012

Compressed fibrin-collagen scaffolds for enhancing bladder tissue regeneration: a bioreactor cell culture system

Jeffrey Alan Hubbell, Peter Frey, Eva-Maria Balet, Elif Vardar

Wiley-Blackwell2012

Sorting Live Stem Cells Based on Sox2 mRNA Expression

Matthias Lütolf, Jeffrey Alan Hubbell, Peter Frey, Seung Tae Lee, Hans Mattias Larsson

While cell sorting usually relies on cell-surface protein markers, molecular beacons (MBs) offer the potential to sort cells based on the presence of any expressed mRNA and in principle could be extremely useful to sort rare cell populations from primary i ...

Public Library of Science2012

A collagen-poly(lactic acid-co-epsilon-caprolactone) hybrid scaffold for bladder tissue regeneration

Florian Maria Wurm, Lionel Ambroise Micol, Jeffrey Alan Hubbell, Peter Frey

Scaffold materials should favor cell attachment and proliferation, and provide designable 3D structures with appropriate mechanical strength. Collagen matrices have proven to be beneficial scaffolds for tissue regeneration. However, apart from small intest ...

2011

High-density collagen gel tubes as a matrix for primary human bladder smooth muscle cells

Lionel Ambroise Micol, Jeffrey Alan Hubbell, Peter Frey

Tissue-engineered grafts for the urinary tract are being investigated for the potential treatment of several urologic diseases. These grafts, predominantly tubular-shaped, usually require in vitro culture prior to implantation to allow cell engraftment on ...

Elsevier2011

Tg-aprotinin fusion proteins and matrices thereof

Jeffrey Alan Hubbell, Peter Frey, Kristen Lorentz

Fusion proteins containing a first domain and a second domain, where the first domain contains a crosslinkable substrate domain and the second domain contains a fibrinolysis inhibitor, are provided. In a preferred embodiment, the fibrinolysis inhibitor is ...

2011

Engineered aprotinin for improved stability of fibrin biomaterials

Jeffrey Alan Hubbell, Peter Frey, Stephane Kontos, Kristen Lorentz

Fibrin has been long used clinically for hemostasis and sealing, yet extension of use in other applications has been limited due to its relatively rapid resorption in vivo, even with addition of aprotinin or other protease inhibitors. We report an engineer ...

2011

Compressed collagen gel: a novel scaffold for human bladder cells

Florian Maria Wurm, Jeffrey Alan Hubbell, Peter Frey

Collagen is highly conserved across species and has been used extensively for tissue regeneration; however, its mechanical properties are limited. A recent advance using plastic compression of collagen gels to achieve much higher concentrations significant ...

Wiley-Blackwell2010

In vivo study of an injectable poly(acrylonitrile)-based hydrogel paste as a bulking agent for the treatment of urinary incontinence

Lionel Ambroise Micol, Jeffrey Alan Hubbell, Peter Frey

Urinary incontinence can be treated by endoscopic injection of bulking agents, however, no optimal therapeutic effect has been achieved upon this treatment yet. In the present study, the development of a injectable poly(acrylonitrile) hydrogel paste is des ...

Elsevier2010

Entrainment and motion of coarse particles in a shallow water stream down a steep slope

Anthony Christopher Davison, Christophe Ancey, Peter Frey

We investigate the entrainment, deposition and motion of coarse spherical particles within a turbulent shallow water stream down a steep slope. This is an idealization of bed-load transport in mountain streams. Earlier investigations have described this ki ...

Cambridge University Press2008

The effect of enzymatically degradable poly(ethylene glycol) hydrogels on smooth muscle cell phenotype

Jeffrey Alan Hubbell, Peter Frey

The formation of scar tissue due to dedifferentiation of smooth muscle cells (SMCs) is one of the major issues faced when engineering bladder tissue. Furthermore, cell sources for regenerating the SMC layer are also limiting. Here we explore if human mesen ...

2008

Compressed collagen-PLA hybrids as scaffold for human bladder cells

Florian Maria Wurm, Jeffrey Alan Hubbell, Peter Frey

2008

Fibrin delivery systems for elastic tissue regeneration

Lirong Yang, Jeffrey Alan Hubbell, Thomas Barker, Peter Frey

2008

Bioactive poly(ethylene glycol) hydrogels for modulation of the smooth muscle cell phenotype

Jeffrey Alan Hubbell, Peter Frey

2008

Expression and purification of recombinant aprotinin for enhanced stability of fibrin biomaterials

Jeffrey Alan Hubbell, Peter Frey, Kristen Lorentz

2008

Novel cell-seeded, tubular-shaped and highly dense collagen gel for tissue engineering

Lionel Ambroise Micol, Jeffrey Alan Hubbell, Peter Frey

2008

Statistical description of sediment transport experiments

Christophe Ancey, Peter Frey

A longstanding problem in the study of sediment transport in gravel-bed rivers is related to the physical mechanisms governing bed resistance and particle motion. To study this problem, we investigated the motion of coarse spherical glass beads entrained b ...

2006

Two-dimensional motion of a set of particles in a free surface flow with image processing

Christophe Ancey, Peter Frey

Springer2006

Wide solid-discharge fluctuations and collective effects in bed-load transport

Christophe Ancey, Peter Frey

2006

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