Publications de Reto Bisaz | EPFL Graph Search

Age-related cognitive impairments in mice with a conditional ablation of the neural cell adhesion molecule

Maria del Carmen Sandi Perez, Reto Bisaz, David Genoux

Most of the mechanisms involved in neural plasticity support cognition, and aging has a considerable effect on some of these processes. The neural cell adhesion molecule (NCAM) of the immunoglobulin superfamily plays a pivotal role in structural and functi ...

Cold Spring Harbor Lab Press, Publications Dept2013

Vulnerability of conditional NCAM-deficient mice to develop stress-induced behavioral alterations

Maria del Carmen Sandi Perez, Reto Bisaz

Previous studies in rodents showed that chronic stress induces structural and functional alterations in several brain regions, including shrinkage of the hippocampus and the prefrontal cortex, which are accompanied by cognitive and emotional disturbances. ...

2012

Causal evidence for the involvement of the neural cell adhesion molecule, NCAM, in chronic stress-induced cognitive impairments

Maria del Carmen Sandi Perez, Reto Bisaz

In rodents, chronic stress induces long-lasting structural and functional alterations in the hippocampus, as well as learning and memory impairments. The neural cell adhesion molecule (NCAM) was previously hypothesized to be a key molecule in mediating the ...

Wiley-Blackwell2011

Differential impact of polysialyltransferase ST8SiaII and ST8iaIV knockout on social interaction and aggression

Maria del Carmen Sandi Perez, Reto Bisaz, Cristina Marquez Vega, Martina Fantin

Previous studies using neuronal cell adhesion molecule (NCAM) -/- knockout (KO) mice provided evidence for a role of NCAMs in social behaviors. However, polysialic acid (PSA), the most important post-translational modification of NCAM, was also absent in t ...

Wiley-Blackwell2010

Role of NCAM in emotion and learning

Maria del Carmen Sandi Perez, Kamila Markram, Reto Bisaz, Lisa Conboy

NCAM is an abundant cell adhesion molecule known to be important during development. Together with its posttranslational modification consisting of the addition of the polysaccharide polysialic acid (PSA), NCAM has been classically implicated in the regula ...

2010

The role of NCAM in auditory fear conditioning and its modulation by stress: a focus on the amygdala

Maria del Carmen Sandi Perez, Reto Bisaz

Chronic stress in rodents was shown to induce structural shrinkage and functional alterations in the hippocampus that were linked to spatial memory impairments. Effects of chronic stress on the amygdala have been linked to a facilitation of fear conditioni ...

Wiley-Blackwell2010

Stress-induced cognitive and psychopathological alterations : functional involvement of the neural cell adhesion molecule (NCAM)

Maria del Carmen Sandi Perez, Reto Bisaz

Intensive research over the past few years has provided evidence, that stress is a potent modulator of brain function and cognition. In particular cognitive and emotional processes have been shown to be susceptible to modulation by stress. Whereas acute st ...

EPFL2009

Learning under stress: a role for the neural cell adhesion molecule NCAM

Maria del Carmen Sandi Perez, Reto Bisaz, Lisa Conboy

Stress is known to be a potent modulator of brain function and cognition. While prolonged and/or excessive stress generally exerts negative effects on learning and memory processes, acute stress can have differential effects on memory function depending on ...

Elsevier2009

KAP1-mediated epigenetic repression in the forebrain modulates behavioral vulnerability to stress

Jean-Charles Bensadoun, Maria del Carmen Sandi Perez, Maria Isabel Cordero Campana, Reto Bisaz, Didier Trono, Johan Jakobsson, Anna Claire Groner

KAP1 is an essential cofactor of KRAB-zinc finger proteins, a family of vertebrate-specific epigenetic repressors of largely unknown functions encoded in the hundreds by the mouse and human genomes. Here, we report that KAP1 is expressed at high levels and ...

2008

A model for the involvement of neural cell adhesion molecules in stress-related mood disorders

Maria del Carmen Sandi Perez, Reto Bisaz

Critical interactions between genetic and environmental factors -- among which stress is one of the most potent non-genomic factors -- are involved in the development of mood disorders. Intensive work during the past decade has led to the proposal of the n ...

Karger2007