Publications de Gediminas Luksys

Glutamine-to-glutamate ratio in the nucleus accumbens predicts effort-based motivated performance in humans

Maria del Carmen Sandi Perez, Rolf Gruetter, Gediminas Luksys, Lijing Xin, Alina Veronika Irene Strasser

Substantial evidence implicates the nucleus accumbens in motivated performance, but very little is known about the neurochemical underpinnings of individual differences in motivation. Here, we applied 1H magnetic resonance spectroscopy (1H-MRS) at ultra-hi ...

2020

Stress, noradrenaline, and realistic prediction of mouse behaviour using reinforcement learning

Wulfram Gerstner, Maria del Carmen Sandi Perez, Gediminas Luksys

Suppose we train an animal in a conditioning experiment. Can one predict how a given animal, under given experimental conditions, would perform the task? Since various factors such as stress, motivation, genetic background, and previous errors in task perf ...

Curran Associates, Inc.2009

Stress, genotype and norepinephrine in the prediction of mouse behavior using reinforcement learning

Wulfram Gerstner, Maria del Carmen Sandi Perez, Gediminas Luksys

Individual behavioral performance during learning is known to be affected by modulatory factors, such as stress and motivation, and by genetic predispositions that influence sensitivity to these factors. Despite numerous studies, no integrative framework i ...

Nature Publishing Group2009

Stress, individual differences, and norepinephrine in reinforcement learning-based prediction of mouse behavior in conditioning and spatial learning

Maria del Carmen Sandi Perez, Gediminas Luksys

Acute stress regulates different aspects of behavioral learning through the action of stress hormones and neuromodulators. Stress effects depend on stressor's type, intensity, timing, and the learning paradigm. In addition, genetic background of animals mi ...

EPFL2009

Modeling spatial and temporal aspects of visual backward masking

Wulfram Gerstner, Michael Herzog, Gediminas Luksys

Visual backward masking is a versatile tool for understanding principles and limitations of visual information processing in the human brain. However, the mechanisms underlying masking are still poorly understood. In the current contribution, the authors s ...

American Psychological Association2008

Effects of stress and genotype on meta-parameter dynamics in reinforcement learning

Wulfram Gerstner, Jérémie Knüsel, Maria del Carmen Sandi Perez, Gediminas Luksys

Stress and genetic background regulate different aspects of behavioral learning through the action of stress hormones and neuromodulators. In reinforcement learning (RL) models, meta-parameters such as learning rate, future reward discount factor, and expl ...

2007