Publications de Igor Allaman | EPFL Graph Search

Lactate in the brain: from metabolic end-product to signalling molecule

Lactate in the brain has long been associated with ischaemia; however, more recent evidence shows that it can be found there under physiological conditions. In the brain, lactate is formed predominantly in astrocytes from glucose or glycogen in response to ...

2018

Dual action of L-Lactate on the activity of NR2B-containing NMDA receptors: from potentiation to neuroprotection

Pierre Marquet, Pierre Magistretti, Pascal Jourdain, Igor Allaman, Kaspar Rothenfusser

L-Lactate is a positive modulator of NMDAR-mediated signaling resulting in plasticity gene induction and memory consolidation. However, L-Lactate is also able to protect neurons against excito-toxic NMDAR activity, an indication of a mitigating action of L ...

Nature Research2018

Functional consequences of brain glycogen deficiency on the sleep-wake cycle regulation in PTG-KO mice

Pierre Magistretti, Igor Allaman, Gabriele Grenningloh, Sophie Burlet Godinot

WILEY2018

Synergistic interaction of L-Lactate and Glycine to potentiate NMDA receptor activity: a new form of meta-potentiation?

Pierre Marquet, Pierre Magistretti, Pascal Jourdain, Igor Allaman, Kaspar Rothenfusser

Wiley2017

Lack of PTG involvement in glycogen regulation during sleep deprivation in mice

Pierre Magistretti, Igor Allaman, Jean-Marie Petit, Gabriele Grenningloh, Sophie Burlet Godinot, Evelyne Ruchti, Jin Teng Chung

Wiley2017

L-Lactate protects neurons against excitotoxicity: implication of an ATP-mediated signaling cascade

Pierre Marquet, Pierre Magistretti, Pascal Jourdain, Igor Allaman, Kaspar Rothenfusser

Converging experimental data indicate a neuroprotective action of L-Lactate. Using Digital Holographic Microscopy, we observe that transient application of glutamate (100 μM; 2 min) elicits a NMDA-dependent death in 65% of mouse cortical neurons in culture ...

Nature Research2016

A Cellular Perspective on Brain Energy Metabolism and Functional Imaging

Pierre Magistretti, Igor Allaman

The energy demands of the brain are high: they account for at least 20% of the body's energy consumption. Evolutionary studies indicate that the emergence of higher cognitive functions in humans is associated with an increased glucose utilization and expre ...

Elsevier2015

Role of glycogen-derived lactate in synaptic plasticity and memory

Pierre Magistretti, Igor Allaman, Gabriele Grenningloh

Wiley-Blackwell2015

Modulation of astrocytic glucose metabolism by the antidiabetic drug metformin

Pierre Magistretti, Igor Allaman, Gabriele Grenningloh

Wiley-Blackwell2015

Methylglyoxal, the dark side of glycolysis

Pierre Magistretti, Igor Allaman

Glucose is the main energy substrate for the brain. There is now extensive evidence indicating that the metabolic profile of neural cells with regard to glucose utilization and glycolysis rate is not homogenous, with a marked propensity for glycolytic gluc ...

Frontiers Research Foundation2015

Multi-timescale Modeling of Activity-Dependent Metabolic Coupling in the Neuron-Glia-Vasculature Ensemble

Pierre Magistretti, Renaud Jolivet, Igor Allaman, Jay Coggan

Glucose is the main energy substrate in the adult brain under normal conditions. Accumulating evidence, however, indicates that lactate produced in astrocytes (a type of glial cell) can also fuel neuronal activity. The quantitative aspects of this so-calle ...

2015

Glycogen metabolism and the homeostatic regulation of sleep

Pierre Magistretti, Igor Allaman, Jean-Marie Petit, Sophie Burlet Godinot

In 1995 Benington and Heller formulated an energy hypothesis of sleep centered on a key role of glycogen. It was postulated that a major function of sleep is to replenish glycogen stores in the brain that have been depleted during wakefulness which is asso ...

Springer Verlag2015

Metabolic gene expression changes in astrocytes in Multiple Sclerosis cerebral cortex are indicative of immune-mediated signaling

Pierre Magistretti, Igor Allaman

Emerging as an important correlate of neurological dysfunction in Multiple Sclerosis (MS), extended focal and diffuse gray matter abnormalities have been found and linked to clinical manifestations such as seizures, fatigue and cognitive dysfunction. To in ...

Elsevier2015

Learning-Induced Gene Expression in the Hippocampus Reveals a Role of Neuron-Astrocyte Metabolic Coupling in Long Term Memory

Sylvain Eric Lengacher, Pierre Magistretti, Igor Allaman, Gabriele Grenningloh, Monika Tadi

We examined the expression of genes related to brain energy metabolism and particularly those encoding glia (astrocyte)-specific functions in the dorsal hippocampus subsequent to learning. Context-dependent avoidance behavior was tested in mice using the s ...

Public Library of Science2015

Lactate promotes plasticity gene expression by potentiating NMDA signaling in neurons

Pierre Magistretti, Pascal Jourdain, Igor Allaman, Jean-Marie Petit, Gabriele Grenningloh, Evelyne Ruchti, Jiangyan Yang

L-lactate is a product of aerobic glycolysis that can be used by neurons as an energy substrate. Here we report that in neurons L-lactate stimulates the expression of synaptic plasticity-related genes such as Arc, c-Fos, and Zif268 through a mechanism invo ...

National Academy of Sciences2014

Inhibitory Avoidance Learning Is Associated With Altered Expression Of Genes Involved In Neuron-Glia Metabolic Coupling

Sylvain Eric Lengacher, Pierre Magistretti, Igor Allaman, Gabriele Grenningloh, Monika Tadi

Wiley-Blackwell2013

Regulation of Neurotrophic Factors and Energy Metabolism by Antidepressants in Astrocytes

Jean-Luc Martin, Pierre Magistretti, Igor Allaman

There is growing evidence that astrocytes are involved in the neuropathology of major depression. In particular, decreases in glial cell density observed in the cerebral cortex of individuals with major depressive disorder are accompanied by a reduction of ...

Bentham Science Publishers2013

Igor Allaman

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Lactate in the brain: from metabolic end-product to signalling molecule

Dual action of L-Lactate on the activity of NR2B-containing NMDA receptors: from potentiation to neuroprotection

Functional consequences of brain glycogen deficiency on the sleep-wake cycle regulation in PTG-KO mice

Synergistic interaction of L-Lactate and Glycine to potentiate NMDA receptor activity: a new form of meta-potentiation?

Lack of PTG involvement in glycogen regulation during sleep deprivation in mice

L-Lactate protects neurons against excitotoxicity: implication of an ATP-mediated signaling cascade

A Cellular Perspective on Brain Energy Metabolism and Functional Imaging

Role of glycogen-derived lactate in synaptic plasticity and memory

Modulation of astrocytic glucose metabolism by the antidiabetic drug metformin

Methylglyoxal, the dark side of glycolysis

Multi-timescale Modeling of Activity-Dependent Metabolic Coupling in the Neuron-Glia-Vasculature Ensemble

Glycogen metabolism and the homeostatic regulation of sleep

Metabolic gene expression changes in astrocytes in Multiple Sclerosis cerebral cortex are indicative of immune-mediated signaling

Learning-Induced Gene Expression in the Hippocampus Reveals a Role of Neuron-Astrocyte Metabolic Coupling in Long Term Memory

Lactate promotes plasticity gene expression by potentiating NMDA signaling in neurons

Inhibitory Avoidance Learning Is Associated With Altered Expression Of Genes Involved In Neuron-Glia Metabolic Coupling

Regulation of Neurotrophic Factors and Energy Metabolism by Antidepressants in Astrocytes

Lactate Modifies Neuronal Excitability Through Both Nmda And Katp Receptors: Importance For Plasticity Genes Expression

Lactate As A Signaling Molecule For The Regulation Of Plasticity-Related Genes Expression

Lactate as a signaling molecule for the regulation of plasticity-related genes expression