Publications de Monia Guidi | EPFL Graph Search

Modeling tumor size dynamics based on real-world electronic health records and image data in advanced melanoma patients receiving immunotherapy

Olivier Michielin, Monia Guidi, Alexandre Wicky, Nadia Terranova, Daniel Abler, Federico Amato

The development of immune checkpoint inhibitors (ICIs) has revolutionized cancer therapy but only a fraction of patients benefits from this therapy. Model-informed drug development can be used to assess prognostic and predictive clinical factors or biomark ...

2023

Impact of Genetic and Nongenetic Factors on Body Mass Index and Waist-Hip Ratio Change in HIV-Infected Individuals Initiating Antiretroviral Therapy

Thierry Buclin, Monia Guidi, Jacques Fellay, Christian Hammer, Christian Axel Wandall Thorball

Objective. There is limited data on abdominal obesity and the influence of genetics on weight change after ant iretroviral therapy (ART) initiation. We assessed body mass index (BMI) and waist hip ration (WHR) change over time in the Swiss HIV Cohort study ...

OXFORD UNIV PRESS INC2020

Cascaded PID controller for anaesthesia delivery

Monia Guidi, Alena Simalatsar

The technologies for continuous measurement of the anaesthetic agents circulating in body fluids are not mature yet, though some preliminary prototypes exist already. We present a control algorithm that based on the real measurement of propofol plasma conc ...

2016

Spectroscopy and dissociation dynamics of cold, biomolecular ions

Monia Guidi

The function of a peptide is intimately connected to its structure, which in solution is the result of the balance between non-covalent interactions within the molecule and the molecule-solvent interactions. Theory has the power to predict the properties o ...

EPFL2010

Spectroscopy of Protonated Peptides Assisted by Infrared Multiple Photon Excitation

Oleg Boyarkine, Thomas Rizzo, Monia Guidi, Georgios Papadopoulos, Ulrich Lorenz

We report here a new technique for spectroscopic studies of protonated, gas- phase biomolecules and demonstrate its utility by measuring highly-resolved electronic and infrared spectra of peptides of up to 17 amino acids. After UV excitation of an aromatic ...

2009

Conformation-specific infrared and ultraviolet spectroscopy of tyrosine-based protonated dipeptides

Oleg Boyarkine, Thomas Rizzo, Monia Guidi

We present the spectroscopy and photofragmentation dynamics of two isomeric protonated dipeptides, H+AlaTyr and H+TyrAla, in a cold ion trap. By a combination of infrared-ultraviolet double resonance experiments and density functional theory calculations, ...

2007

Conformation-specific spectroscopy and photodissociation of cold, protonated tyrosine and phenylalanine

Oleg Boyarkine, Thomas Rizzo, Sébastien Mercier, Monia Guidi, Caroline Seaiby

We present here ultraviolet and infrared spectra of protonated aromatic amino acids in a cold, 22-pole ion trap. Ultraviolet photofragmentation spectra of protonated tyrosine and phenylalanine show vibronically resolved bands corresponding to different sta ...

2007