Publications de Giulio Gambarota

Multi T1-weighted contrast MRI with fluid and white matter suppression at 1.5 T

Introduction: The fluid and white matter suppression sequence (FLAWS) provides two T1-weighted co-registered datasets: a white matter (WM) suppressed contrast (FLAWS1) and a cerebrospinal fluid (CSF) suppressed contrast (FLAWS2). FLAWS has the potential to ...

ELSEVIER SCIENCE INC2019

Magnetization transfer-based 3D visualization of foot peripheral nerves

Giulio Gambarota, Bénédicte Marie Maréchal, Gunnar Krüger, Cristina Granziera

PURPOSE: To investigate magnetization transfer (MT) effects as a new source of contrast for imaging and tracking of peripheral foot nerves. MATERIALS AND METHODS: Two sets of 3D spoiled gradient-echo images acquired with and without a saturation pulse were ...

Wiley-Blackwell2013

Single spin-echo T 2 relaxation times of cerebral metabolites at 14.1 T in the in vivo rat brain

Rolf Gruetter, Giulio Gambarota, Lijing Xin, Cristina Ramona Cudalbu

OBJECT: To determine the single spin-echo T 2 relaxation times of uncoupled and J-coupled metabolites in rat brain in vivo at 14.1 T and to compare these results with those previously obtained at 9.4 T. MATERIALS AND METHODS: Measurements were performed on ...

Springer Verlag2013

Magnetic resonance imaging of peripheral nerves: Differences in magnetization transfer

Giulio Gambarota, Gunnar Krüger

Introduction: Magnetic resonance imaging (MRI) is an excellent imaging modality for soft tissues. Magnetization transfer (MT) imaging is an MRI technique that is sensitive to the bound protons of macromolecules and therefore can aid in the assessment of ne ...

2012

Fluid and white matter suppression with the MP2RAGE sequence

Giulio Gambarota, Gunnar Krüger, Tobias Kober, José Pedro Rebelo Ferreira Marques

Purpose: To develop a magnetic resonance imaging (MRI) sequence (fluid and white matter suppression, FLAWS) for generating two sets of images from a single acquisition: one with contrast similar to a T1-weighted magnetization-prepared rapid gradient-echo s ...

Wiley-Blackwell2012

Direct in vivo measurement of glycine and the neurochemical profile in the rat medulla oblongata

Rolf Gruetter, Giulio Gambarota, Lijing Xin, João Miguel das Neves Duarte

The medulla oblongata (MO) contains a high density of glycinergic synapses and a particularly high concentration of glycine The aims of this study were to measure directly in vivo the neurochemical profile, including glycine, in MO using a spin-echo-based ...

Wiley-Blackwell2010

Echo-time independent signal modulations for strongly coupled systems in triple echo localization schemes: An extension of S-PRESS editing

Rolf Gruetter, Giulio Gambarota

The double spin-echo point resolved spectroscopy sequence (PRESS) is a widely used method and standard in clinical MR spectroscopy. Existence of important J-modulations at constant echo times, depending on the temporal delays between the rf-pulses, have be ...

Academic Press Inc - Elsevier Science2010

MR Spectroscopy of the Human Brain With Enhanced Signal Intensity at Ultrashort Echo Times on a Clinical Platform at 3T and 7T

Rolf Gruetter, Giulio Gambarota, Gunnar Krüger

Recently, the spin-echo full-intensity acquired localized (SPECIAL) spectroscopy technique was proposed to unite the advantages of short TEs on the order of milliseconds (ms) with full sensitivity and applied to in vivo rat brain. In the present study, SPE ...

Wiley-Blackwell2009

NMR Properties of Human Median Nerve at 3 T: Proton Density, T1, T2, and Magnetization Transfer

Giulio Gambarota, Gunnar Krüger

Purpose: To measure the proton density (PD), the T1 and T2 relaxation time, and magnetization transfer (MT) effects in human median nerve at 3 T and to compare them with the corresponding values in muscle. ...

Wiley-Blackwell2009

T2 Relaxometry of Human Median Nerve

Giulio Gambarota

This article examines the T2 relaxation characteristics of the median nerve. Knowledge of the T2 relaxation time is essential to optimize clinical magnetic resonance imaging (MRI) protocols and to enhance the visibility of pathophysiological changes in tis ...

Thieme Publishing2009

In vivo measurement of glycine with short echo-time H-1 MRS in human brain at 7 T

Rolf Gruetter, Giulio Gambarota, Lijing Xin, Wietske Van der Zwaag, Gunnar Krüger

To determine whether glycine can be measured at 7 T in human brain with H-1 magnetic resonance spectroscopy (MRS). ...

2009

Glycine Tissue Level in Medulla Oblongata Measured in vivo with 1H MRS at 9.4 T in Rat Brain

Rolf Gruetter, Giulio Gambarota, Lijing Xin, João Miguel das Neves Duarte

2009

In vivo H-1 NMR measurement of glycine in rat brain at 9.4 T at short echo time

Chiara Perazzolo, Rolf Gruetter, Giulio Gambarota, Lijing Xin

Glycine is an amino acid present in mammalian brain, where it acts as an inhibitory and excitatory neurotransmitter. The two detectable protons of glycine give rise to a singlet at 3.55 ppm that overlaps with the more intense myo-inositol resonances, and i ...

Wiley-Blackwell2008

Quantitative proton spectroscopic imaging of the neurochemical profile in rat brain with microliter resolution at ultra-short echo times

Rolf Gruetter, Giulio Gambarota

Proton spectroscopy allows the simultaneous quantification of a high number of metabolite concentrations termed the neurochemical profile. The spin echo full intensity acquired localization (SPECIAL) scheme with an echo time of 2.7 ms was used at 9.4T for ...

Wiley-Blackwell2008

Proton T-2 relaxation time of J-coupled cerebral metabolites in rat brain at 9.4T

Rolf Gruetter, Giulio Gambarota, Lijing Xin

Knowledge of proton T-2 relaxation time of metabolites is essential for proper quantitation of metabolite concentrations in localized proton spectroscopy, especially at moderate to long TEs. Although the T-2 relaxation time of singlets, such as that of cre ...

Wiley-Blackwell2008

Characterisation of tumour vasculature in mouse brain by USPIO contrast-enhanced MRI

Giulio Gambarota

To enhance the success rate of antiangiogenic therapies in the clinic, it is crucial to identify parameters for tumour angiogenesis that can predict response to these therapies. In brain tumours, one such parameter is vascular leakage, which is a response ...

Nature Publishing Group2008

High-Quality MR Spectroscopy of the Human Brain with Full Signal Intensity at Echo Times Below 6 ms on a Clinical Platform at 3T and 7T

Rolf Gruetter, Giulio Gambarota, Gunnar Krüger

2008

Hahn T2 Relaxation Times of the Neurochemical Profile at 14.1T in the in vivo Rat Brain

Rolf Gruetter, Giulio Gambarota, Lijing Xin, Cristina Ramona Cudalbu

2008

Magnetic resonance imaging and T2 relaxometry of human median nerve at 7 Tesla

Giulio Gambarota

Measurements of T2 relaxation times in tissues have provided a unique, noninvasive method to investigate the microenvironment of water molecules in vivo. As more clinical imaging is performed at higher field strengths, tissue relaxation times need to be re ...

Wiley-Blackwell2007

Precision of metabolite concentrations obtained by LCModel as a function of the signal-to-noise ratio in rodent brain

Rolf Gruetter, Giulio Gambarota, Lijing Xin

2007