Publications de Marc Moniatte | EPFL Graph Search

Human proteinase 3 resistance to inhibition extends to alpha-2 macroglobulin

Polymorphonuclear neutrophils contain at least four serine endopeptidases, namely neutrophil elastase (NE), proteinase 3 (PR3), cathepsin G (CatG), and NSP4, which contribute to the regulation of infection and of inflammatory processes. In physiological co ...

2020

A high resolution LC-MS targeted method for the concomitant analysis of 11 contraceptive progestins and 4 steroids

Alexandre Béguin, Cathrin Brisken, Marc Moniatte, Jonathan Paz Montoya, Marie Shamseddin, Csaba Ferenc László, Fabio De Martino

In the context of hormonal contraception and hormone replacement therapy (HRT), many women are exposed to exogenous hormones. Current use of hormonal contraception with combined ethinyl estradiol and different progestins bestows a breast cancer relative ri ...

2019

Analysis of the S. pombe Meiotic Proteome Reveals a Switch from Anabolic to Catabolic Processes and Extensive Post-transcriptional Regulation

Marc Moniatte, Diego Chiappe, Viesturs Simanis, Andrea Krapp, Elena Cano, Florence Armand, Romain Hamelin, Lucien Fabrice Krapp

Meiotic progression in S. pombe is regulated by stage-specific gene expression and translation, changes in RNA stability, expression of anti-sense transcripts, and targeted proteolysis of regulatory proteins. We have used SILAC labeling to examine the rela ...

2019

Cyclodextrin triggers MCOLN1-dependent endo-lysosome secretion in Niemann-Pick type C cells[S]

Marc Moniatte, Jonathan Paz Montoya

In specialized cell types, lysosome-related organelles support regulated secretory pathways, whereas in nonspecialized cells, lysosomes can undergo fusion with the plasma membrane in response to a transient rise in cytosolic calcium. Recent evidence also i ...

2019

Drug-induced increase in lysobisphosphatidic acid reduces the cholesterol overload in Niemann-Pick type C cells and mice

Marc Moniatte, Jonathan Paz Montoya

Most cells acquire cholesterol by endocytosis of circulating low-density lipoproteins (LDLs). After cholesteryl ester de-esterification in endosomes, free cholesterol is redistributed to intracellular membranes via unclear mechanisms. Our previous work sug ...

2019

Phosphorylation of the VAR2CSA extracellular region is associated with enhanced adhesive properties to the placental receptor CSA

Marc Moniatte, Florence Armand, Romain Hamelin

Plasmodium falciparum is the main cause of disease and death from malaria. P. falciparum virulence resides in the ability of infected erythrocytes (IEs) to sequester in various tissues through the interaction between members of the polymorphic P. falciparu ...

2019

Phosphorylation Of The Var2Csa Extracellular Region Is Associated With Enhanced Adhesive Properties To The Placental Receptor Csa

Marc Moniatte, Florence Armand, Romain Hamelin, Zeineb Fourati

AMER SOC TROP MED & HYGIENE2019

Antibody-based methods for the measurement of α-synuclein concentration in human cerebrospinal fluid - method comparison and round robin study

Hilal Lashuel, Adrian Schmid, Marc Moniatte

2019

Sexual dimorphism in hepatic lipids is associated with the evolution of metabolic status in mice

Rolf Gruetter, Marc Moniatte, Hongxia Lei, Jonathan Paz Montoya, Ana Francisca Leal Silva Soares

Ectopic lipid accumulation in the liver is implicated in metabolic disease in an age- and sex-dependent manner. The role of hepatic lipids has been well established within the scope of metabolic insults in mice, but has been insufficiently characterized un ...

Wiley-Blackwell2017

Lipidomics reveals diurnal lipid oscillations in human skeletal muscle persisting in cellular myotubes cultured in vitro

Marc Moniatte, Howard Riezman, Jonathan Paz Montoya, Frédéric Bruno Martin Gachon, Benjamin Dieter Weger

Circadian clocks play an important role in lipid homeostasis, with impact on various metabolic diseases. Due to the central role of skeletal muscle in whole-body metabolism, we aimed at studying muscle lipid profiles in a temporal manner. Moreover, it has ...

National Academy of Sciences2017

Protein Corona: Impact of Lymph Versus Blood in a Complex In Vitro Environment

Heinrich Hofmann, Ulrich Aschauer, Marc Moniatte, Diego Chiappe, Marijana Mionic Ebersold, Duncan Thomas Lindsay Alexander, Débora Bonvin

In biological environments, the surface of nanoparticles (NPs) are modified by protein corona (PC) that determines their biological behavior. Unfortunately, in vitro tests still give different PC than in vivo tests causing in vitro-in vivo discrepancy; hen ...

Wiley-Blackwell2017

Methods of protein corona isolation for magnetic nanoparticles

Heinrich Hofmann, Marc Moniatte, Diego Chiappe, Marijana Mionic Ebersold, Débora Bonvin

Nanoparticles (NPs) in contact with a biological environment get covered by proteins and some are loosely bound and some are tightly bound. The latter form a hard protein corona (HPC) which is known to determine their biological behavior. Therefore, in ord ...

Royal Soc Chemistry2017

Agents utiles dans le diagnostic et la thérapie de troubles liés à l'agrégation de bêta-amyloïde et procédés de criblage

Marc Moniatte

The present invention relates to novel fragments of beta-amyloid peptide and molecules binding thereto, as well as the use of said fragments and molecules in a method for prognosing/diagnosing and/or preventing/treating beta-amyloid aggregation related dis ...

2017

A comparison of orbitally-shaken and stirred-tank bioreactors: pH modulation and bioreactor type affect CHO cell growth and protein glycosylation

Florian Maria Wurm, Lucia Baldi Unser, David Hacker, Marc Moniatte, Valentin Juvet, Dominique Terry Monteil Jr

Orbitally shaken bioreactors (OSRs) support the suspension cultivation of animal cells at volumetric scales up to 200 L and are a potential alternative to stirred-tank bioreactors (STRs) due to their rapid and homogeneous mixing and high oxygen transfer ra ...

American Chemical Society2016

Amyloid-beta oligomerization is associated with the generation of a typical peptide fragment fingerprint

Cyntia De Piano, Nikita Rudinskiy, Adrian Schmid, Marc Moniatte, Davide Demurtas, Christophe Fuerer

Amyloid-beta (A beta) peptide oligomerization plays a central role in the pathogenesis of Alzheimer's disease (AD), and A beta oligomers are collectively considered an appealing therapeutic target for the treatment of AD. However, the molecular mechanisms ...

Elsevier Science Inc2016

Malaria Parasite-Infected Erythrocytes Secrete PfCK1, the Plasmodium Homologue of the Pleiotropic Protein Kinase Casein Kinase 1

Marc Moniatte, Florence Armand, Romain Hamelin

Casein kinase 1 (CK1) is a pleiotropic protein kinase implicated in several fundamental processes of eukaryotic cell biology. Plasmodium falciparum encodes a single CK1 isoform, PfCK1, that is expressed at all stages of the parasite's life cycle. We have p ...

Public Library of Science2015

Identification of new Presenilin-1 phosphosites: implication for gamma-secretase activity and A beta production

Marc Moniatte, Patrick Fraering, Blanka Halamoda, Alexandre Matz, Mitko Dimitrov, Romain Hamelin, Sébastien Mosser

An important pathological hallmark of Alzheimer's disease (AD) is the deposition of amyloid-beta (A) peptides in the brain parenchyma, leading to neuronal death and impaired learning and memory. The protease -secretase is responsible for the intramembrane ...

Wiley-Blackwell2015

A mammalian transcription factor-specific peptide repository for targeted proteomics

Jovan Simicevic, Marc Moniatte, Bart Deplancke, Romain Hamelin

Site-specific transcription factors (TFs) play an essential role in mammalian development and function as they are vital for the majority of cellular processes. Despite their biological importance, TF proteomic data is scarce in the literature, likely due ...

Wiley-Blackwell2015

Quantitative Mass Spectrometry Reveals Plasticity of Metabolic Networks in Mycobacterium smegmatis

Marc Moniatte, Diego Chiappe, John McKinney, Tarun Chopra, Florence Armand, Romain Hamelin

Mycobacterium tuberculosis has a remarkable ability to persist within the human host as a clinically inapparent or chronically active infection. Fatty acids are thought to be an important carbon source used by the bacteria during long term infection. Catab ...

Amer Soc Biochemistry Molecular Biology Inc2014

Genetic engineering of cell lines using lentiviral vectors to achieve antibody secretion following encapsulated implantation

Patrick Aebischer, Bernard Schneider, Marc Moniatte, Aurélien Lathuilière

The controlled delivery of antibodies by immunoisolated bioimplants containing genetically engineered cells is an attractive and safe approach for chronic treatments. To reach therapeutic antibody levels there is a need to generate renewable cell lines, wh ...

Elsevier2014