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Lijing Xin

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Publications associées (123)

Developmental changes in cerebral NAD and neuroenergetics of an antioxidant compromised mouse model of schizophrenia

Lijing Xin

Defects in essential metabolic regulation for energy supply, increased oxidative stress promoting excitatory/inhibitory imbalance and phospholipid membrane dysfunction have been implicated in the pathophysiology of schizophrenia (SZ). The knowledge about t ...

SPRINGERNATURE2023

Effect of circadian rhythm on NAD and other metabolites in human brain

Lijing Xin, Daniel Wenz, Mark Stephan Widmaier

Nicotinamide Adenine Dinucleotide (NAD) plays a central role in the master circadian clock of the brain (the suprachiasmatic nuclei, SCN) as demonstrated in many model organisms. NAD acts as an enzyme co-factor and substrate and its modulation was found to ...

Frontiers Media Sa2023

Dipolectric antenna for high-field MRI

Lijing Xin, Daniel Wenz

Purpose: To introduce the dipolectric antenna: a novel RF coil design for high-field MRI using a combination of a dipole antenna with a loop-coupled dielectric resonator antenna. ...

WILEY2023

Bridging structural MRI with cognitive function for individual level classification of early psychosis via deep learning

Lijing Xin

IntroductionRecent efforts have been made to apply machine learning and deep learning approaches to the automated classification of schizophrenia using structural magnetic resonance imaging (sMRI) at the individual level. However, these approaches are less ...

FRONTIERS MEDIA SA2023

High field brain proton magnetic resonance spectroscopy and volumetry in children with chronic, compensated liver disease-A pilot study

Sarah Lachat, Lijing Xin, Bénédicte Marie Maréchal, Cristina Ramona Cudalbu

Background: There is increasing evidence that children or young adults having acquired liver disease in childhood display neurocognitive impairment which may become more apparent as they grow older. The molecular, cellular and morphological underpinnings o ...

ACADEMIC PRESS INC ELSEVIER SCIENCE2023

Glutathione in the nucleus accumbens regulates motivation to exert reward-incentivized effort

Pascal Steiner, Maria del Carmen Sandi Perez, Lijing Xin, Olivia Zanoletti, Fiona Hollis, Alina Veronika Irene Strasser, Ioannis Zalachoras, Simone Astori, João Pedro de Matos Rodrigues, Eva Ramos Fernandez

Emerging evidence is implicating mitochondrial function and metabolism in the nucleus accumbens in motivated performance. However, the brain is vulnerable to excessive oxidative insults resulting from neurometabolic processes, and whether antioxidant level ...

2022

gamma-aminobutyric acid measurement in the human brain at 7 T: Short echo-time or Mescher-Garwood editing

Lijing Xin, Songi Lim

The purposes of the current study were to introduce a Mescher-Garwood (MEGA) semi-adiabatic spin-echo full-intensity localization (MEGA-sSPECIAL) sequence with macromolecule (MM) subtraction and to compare the test-retest reproducibility of gamma-aminobuty ...

WILEY2022

In vivo magnetic resonance P-31-Spectral Analysis With Neural Networks: 31P-SPAWNN

François Lazeyras, Sébastien Courvoisier, Lijing Xin, Julien Songeon

Purpose: We have introduced an artificial intelligence framework, 31P-SPAWNN, in order to fully analyze phosphorus-31 (P-31) magnetic resonance spectra. The flexibility and speed of the technique rival traditional least-square fitting methods, with the per ...

WILEY2022

Metabolic and transcriptomic profiles of glioblastoma invasion revealed by comparisons between patients and corresponding orthotopic xenografts in mice

Lijing Xin, Cristina Ramona Cudalbu, Mario Gaetano Lepore, Marta Lai

The invasive behavior of glioblastoma, the most aggressive primary brain tumor, is considered highly relevant for tumor recurrence. However, the invasion zone is difficult to visualize by Magnetic Resonance Imaging (MRI) and is protected by the blood brain ...

2021

Redox Dysregulation, Myelination Deficit and Dysconnectivity in Schizophrenia: A Translational Study in First Episode Patients and Experimental Models

Patric Hagmann, Rolf Gruetter, Lijing Xin, Alessandra Griffa

ELSEVIER SCIENCE INC2021

In vivo macromolecule signals in rat brain 1 H‐MR spectra at 9.4T: Parametrization, spline baseline estimation, and T 2 relaxation times

Bernard Lanz, Lijing Xin, Cristina Ramona Cudalbu, Veronika Rackayová, Dunja Simicic

Purpose Reliable detection and fitting of macromolecules (MM) are crucial for accurate quantification of brain short-echo time (TE) 1H-MR spectra. An experimentally acquired single MM spectrum is commonly used. Higher spectral resolution at ultra-high fiel ...

Wiley2021

Timely N-Acetyl-Cysteine and Environmental Enrichment Rescue Oxidative Stress-Induced Parvalbumin Interneuron Impairments via MMP9/RAGE Pathway: A Translational Approach for Early Intervention in Psychosis

Lijing Xin

Research in schizophrenia (SZ) emphasizes the need for new therapeutic approaches based on antioxidant/anti-inflammatory compounds and psycho-social therapy. A hallmark of SZ is a dysfunction of parvalbumin-expressing fast-spiking interneurons (PVI), which ...

2021

Glutamine-to-glutamate ratio in the nucleus accumbens predicts effort-based motivated performance in humans

Maria del Carmen Sandi Perez, Rolf Gruetter, Gediminas Luksys, Lijing Xin, Alina Veronika Irene Strasser

Substantial evidence implicates the nucleus accumbens in motivated performance, but very little is known about the neurochemical underpinnings of individual differences in motivation. Here, we applied 1H magnetic resonance spectroscopy (1H-MRS) at ultra-hi ...

2020

Magnetic resonance spectroscopy in the rodent brain: Experts' consensus recommendations

Bernard Lanz, Rolf Gruetter, Lijing Xin, Cristina Ramona Cudalbu

In vivo MRS is a non-invasive measurement technique used not only in humans, but also in animal models using high-field magnets. MRS enables the measurement of metabolite concentrations as well as metabolic rates and their modifications in healthy animals ...

WILEY2020

In vivo P-31 magnetic resonance spectroscopy study of mouse cerebral NAD content and redox state during neurodevelopment

Lijing Xin

Nicotinamide adenine dinucleotide (NAD) is an important cofactor of energy-producing pathways. The redox ratio (NAD(+)/NADH) reflects the cellular oxidoreductive state. Oxidative stress and redox dysregulation have been suggested to contribute to various n ...

NATURE RESEARCH2020

Brain NAD Is Associated With ATP Energy Production and Membrane Phospholipid Turnover in Humans

Rolf Gruetter, Lijing Xin, Maya Shevlyakova, Özlem Ipek

The brain requires a large amount of energy, mostly derived from the metabolism of glucose, which decreases substantially with age and neurological diseases. While mounting evidence in model organisms illustrates the central role of brain nicotinamide aden ...

FRONTIERS MEDIA SA2020

Profiling Glutamate And D-Serine Pathways In Treatment Resistant Early Psychosis Patients

Lijing Xin, Kim Do

OXFORD UNIV PRESS2020

MMP9/RAGE pathway overactivation mediates redox dysregulation and neuroinflammation, leading to inhibitory/excitatory imbalance: a reverse translation study in schizophrenia patients

Lijing Xin, Basilio Giangreco, Daniella Dwir, Kim Do

ious mechanisms involved in schizophrenia pathophysiology, such as dopamine dysregulation, glutamate/NMDA receptor dysfunction, neuroinflammation or redox imbalance, all appear to converge towards an oxidative stress "hub" affecting parvalbumine interneuro ...

2020

Redox Dysregulation, Myelination Deficit and Dysconnectivity in Schizophrenia: A Translational Study in First Episode Patients and Experimental Models

Patric Hagmann, Rolf Gruetter, Lijing Xin, Alessandra Griffa, Aline Monin, Emeline Mullier, Kim Do

ELSEVIER SCIENCE INC2020

Contribution of macromolecules to brain H-1 MR spectra: Experts' consensus recommendations

Rolf Gruetter, Lijing Xin, Hongxia Lei, Cristina Ramona Cudalbu, Veronika Rackayová, Dunja Simicic

Proton MR spectra of the brain, especially those measured at short and intermediate echo times, contain signals from mobile macromolecules (MM). A description of the main MM is provided in this consensus paper. These broad peaks of MM underlie the narrower ...

WILEY2020

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