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Hongxia Lei

Cette personne n’est plus à l’EPFL

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Publications associées (68)

Comparison diffusion behavior of metabolites in brains of congenital portal systemic shunt and healthy mice in vivo at 14.1 t

Nicolas Kunz, Rolf Gruetter, Hongxia Lei, Masoumeh Dehghani Moghadam

Wiley2017

Technical and experimental features of Magnetic Resonance Spectroscopy of brain glycogen metabolism

Rolf Gruetter, Hongxia Lei, Ana Francisca Leal Silva Soares

In the brain, glycogen is a source of glucose not only in emergency situations but also during normal brain activity. Altered brain glycogen metabolism is associated with energetic dysregulation in pathological conditions, such as diabetes or epilepsy. Bot ...

Elsevier2017

Hierarchical status predicts behavioral vulnerability and nucleus accumbens metabolic profile following chronic social defeat stress

Maria del Carmen Sandi Perez, Rolf Gruetter, Hongxia Lei, Antoine Timothée Cherix, Thomas Didier Larrieu, João Pedro de Matos Rodrigues, Maria Aranzazu Duque Moreno

Extensive data highlight the existence of major differences in individuals’ susceptibility to stress [1; 2; 3 ; 4]. While genetic factors [5 ; 6] and exposure to early life stress [7 ; 8] are key components for such neurobehavioral diversity, intriguing ob ...

2017

Early detection of human glioma sphere xenografts in mouse brain using diffusion MRI at 14.1 T

Rolf Gruetter, Hongxia Lei

Glioma models have provided important insights into human brain cancers. Among the investigative tools, MRI has allowed their characterization and diagnosis. In this study, we investigated whether diffusion MRI might be a useful technique for early detecti ...

Wiley-Blackwell2016

Fasting-induced changes of hepatic lipid and carbohydrate stores in the absence of GLUT2

Rolf Gruetter, Hongxia Lei, Ana Francisca Leal Silva Soares

Wiley-Blackwell2015

Direct noninvasive estimation of myocardial tricarboxylic acid cycle flux in vivo using hyperpolarized 13C magnetic resonance

Arnaud Comment, Rolf Gruetter, Hongxia Lei, Tian Cheng, Josefina Adriana Maria Bastiaansen

BACKGROUND: The heart relies on continuous energy production and imbalances herein impair cardiac function directly. The tricarboxylic acid (TCA) cycle is the primary means of energy generation in the healthy myocardium, but direct noninvasive quantificati ...

Elsevier2015

Noninvasive assessment of presymptomatic and symptomatic metabolic changes in the brain and brainstem of an ALS mouse model

Rolf Gruetter, Hongxia Lei

Wiley-Blackwell2015

Assessment of metabolic fluxes in the mouse brain in vivo using (1)H-[(13)C] NMR spectroscopy at 14.1 Tesla

Bernard Lanz, Rolf Gruetter, Lijing Xin, Hongxia Lei

(13)C magnetic resonance spectroscopy (MRS) combined with the administration of (13)C labeled substrates uniquely allows to measure metabolic fluxes in vivo in the brain of humans and rats. The extension to mouse models may provide exclusive prospect for t ...

Nature Publishing Group2015

Characterization of hepatic fatty acids in mice with reduced liver fat by ultra-short echo time (1) H-MRS at 14.1 T in vivo

Rolf Gruetter, Hongxia Lei, Ana Francisca Leal Silva Soares

Alterations in the hepatic lipid content (HLC) and fatty acid composition are associated with disruptions in whole body metabolism, both in humans and in rodent models, and can be non-invasively assessed by (1) H-MRS in vivo. We used (1) H-MRS to character ...

Wiley-Blackwell2015

Non-invasive diagnostic biomarkers for estimating the onset time of permanent cerebral ischemia

Rolf Gruetter, Lijing Xin, Hongxia Lei, Corinne Benakis, Lara Buscemi Estefanell

The treatments for ischemic stroke can only be administered in a narrow time-window. However, the ischemia onset time is unknown in ~30% of stroke patients (wake-up strokes). The objective of this study was to determine whether MR spectra of ischemic brain ...

Nature Publishing Group2014

Impact of hepatic lipid accumulation and composition on glucose tolerance and insulin sensitivity: a longitudinal study in male and female mice

Rolf Gruetter, Hongxia Lei, Ana Francisca Leal Silva Soares

Background and aims: Metabolic disruptions characterized by high hepatic lipid content (HLC) are associated with impairments in whole body glucose homeostasis. To gain insight on the role of hepatic lipids in the metabolic performance in the absence artifi ...

Springer2014

MRS glucose mapping and PET joining forces: Re-evaluation of the lumped constant in the rat brain under isoflurane anaesthesia

Rolf Gruetter, João Miguel das Neves Duarte, Hongxia Lei, Malte Alf

Although numerous positron emission tomography (PET) studies with ((8) F-fluoro-deoxyglucose) FDG have reported quantitative results on cerebral glucose kinetics and consumption, there is a large variation between the absolute values found in the literatur ...

Wiley-Blackwell2014

Impact of hepatic lipid accumulation and composition on glucose tolerance and insulin sensitivity: a longitudinal study in male and female mice

Rolf Gruetter, Hongxia Lei, Ana Francisca Leal Silva Soares

Springer2014

Ultra-High Field Birdcage Coils: a Comparison Study at 14.1T

Arnaud Comment, Rolf Gruetter, Hongxia Lei, Tian Cheng

An essential feature of magnetic resonance (MR) probes for magnetic resonance imaging and spectroscopy is the ability to generate uniform B-1(+) excitation in a volume of interest. When the magnetic field strength is increased, leading to an increase in re ...

Ieee2014

The C57BL/6J Mouse Exhibits Sporadic Congenital Portosystemic Shunts

Rolf Gruetter, João Miguel das Neves Duarte, Hongxia Lei, Cristina Ramona Cudalbu

C57BL/6 mice are the most widely used strain of laboratory mice. Using in vivo proton Magnetic Resonance Spectroscopy (1H MRS), we have repeatedly observed an abnormal neurochemical profile in the brains of both wild-type and ge ...

Public Library of Science2013

MAGNETIC RESONANCE AND BIOLUMINESCENCE IMAGING MONITOR QUANTITATIVE DIFFERENCES IN PANCREATIC ISLETS AND THEIR REGENERATION AFTER BETA CELL LOSS

Rolf Gruetter, Hongxia Lei

FEDERATION AMER SOC EXP BIOL, 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA2013

Studying effects of glucose transporter isoform 2 on brain metabolic activities using localized H-1 MRS and perfusion MRI

Rolf Gruetter, Hongxia Lei

Wiley-Blackwell2013

Improved lipid profiling of the mouse liver by 1H-NMR spectroscopy at 14.1T in vivo

Rolf Gruetter, Hongxia Lei, Ana Francisca Leal Silva Soares

Purpose/Introduction: Whole-body metabolic deregulation features changes in hepatic lipid dynamics. In vivo 1H-MRS allows to noninvasively assess hepatic lipid content (HLC) and composition both in humans [1] and rodents [2]. Transgenic mice provide insigh ...

Springer2012

The neurochemical profile quantified by in vivo(1)H NMR spectroscopy

Rolf Gruetter, João Miguel das Neves Duarte, Hongxia Lei

Proton NMR spectroscopy is emerging from translational and preclinical neuroscience research as an important tool for evidence based diagnosis and therapy monitoring. It provides biomarkers that offer fingerprints of neurological disorders even in cases wh ...

2012

A comparison of high-pass birdcage coils for small animal imaging at 9.4 and 14T

Arnaud Comment, Rolf Gruetter, Hongxia Lei, Tian Cheng, Jennifer Jung

2012

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