Publications de Blaise Lovisa | EPFL Graph Search

Determination of the radiance of cylindrical light diffusers: design of a one-axis charge-coupled device camera-based goniometer setup

Georges Wagnières, Matthieu Philippe Emmanuel Zellweger, Blaise Lovisa, Andreas Pitzschke, Jenny Bertholet

A one-axis charge-coupled device camera-based goniometer setup was developed to measure the three-dimensional radiance profile ( longitudinal, azimuthal, and polar) of cylindrical light diffusers in air and water. An algorithm was programmed to project the ...

SPIE Society of Photo-optical Instrumentation Engineers2017

Red and NIR light dosimetry in the human deep brain

Georges Wagnières, Matthieu Philippe Emmanuel Zellweger, Blaise Lovisa

Photobiomodulation (PBM) appears promising to treat the hallmarks of Parkinson's Disease (PD) in cellular or animal models. We measured light propagation in different areas of PD-relevant deep brain tissue during transcranial, transsphenoidal illumination ...

Iop Publishing Ltd2015

Photobiomodulation Suppresses Alpha-Synuclein-Induced Toxicity in an AAV-Based Rat Genetic Model of Parkinson's Disease

Hubert van den Bergh, Georges Wagnières, Hilal Lashuel, Blaise Lovisa, Abid Oueslati, John Perrin

Converging lines of evidence indicate that near-infrared light treatment, also known as photobiomodulation (PBM), may exert beneficial effects and protect against cellular toxicity and degeneration in several animal models of human pathologies, including n ...

Public Library of Science2015

Optical properties of rabbit brain in the red and near-infrared: changes observed under in vivo, postmortem, frozen, and formalin-fixated conditions

Georges Wagnières, Matthieu Philippe Emmanuel Zellweger, Blaise Lovisa, Andreas Pitzschke

The outcome of light-based therapeutic approaches depends on light propagation in biological tissues, which is governed by their optical properties. The objective of this study was to quantify optical properties of brain tissue in vivo and postmortem and a ...

SPIE Society of Photo-optical Instrumentation Engineers2015

Optical spectroscopy of the bladder washout fluid to optimize fluorescence cystoscopy with Hexvix

Hubert van den Bergh, Georges Wagnières, Matthieu Philippe Emmanuel Zellweger, Blaise Lovisa, Carla Martoccia

Fluorescence cystoscopy enhances detection of early bladder cancer. Water used to inflate the bladder during the procedure rapidly contains urine, which may contain fluorochromes. This frequently degrades fluorescence images. Samples of bladder washout flu ...

SPIE Society of Photo-optical Instrumentation Engineers2014

Angiostatic kinase inhibitors to sustain photodynamic angio-occlusion

Hubert van den Bergh, Patrycja Nowak-Sliwinska, Blaise Lovisa

Targeted angiostatic therapy receives major attention for the treatment of cancer and exudative age-related macular degeneration (AMD). Photodynamic therapy (PDT) has been used as an effective clinical approach for these diseases. Since PDT can cause an an ...

2012

Endoscopic Fluorescence Imaging : Spectral Optimization and in vivo Characterization of Positive Sites by Magnifying Vascular Imaging

Blaise Lovisa

Since several decades, the physicians are able to access hollow organs with endoscopic methods, which serve both as diagnostic and surgical means in a wide range of disciplines of the modern medicine (e.g. urology, pneumology, gastroenterology). Unfortunat ...

EPFL2010

High-magnification vascular imaging to reject false-positive sites in situ during Hexvix® fluorescence cystoscopy

Hubert van den Bergh, Georges Wagnières, Blaise Lovisa

Fluorescence imaging for detection of non-muscle-invasive bladder cancer is based on the selective production and accumulation of fluorescing porphyrins-mainly, protoporphyrin IX-in cancerous tissues after the instillation of Hexvix (R). Although the sensi ...

SPIE Society of Photo-optical Instrumentation Engineers2010

Autofluorescence bronchoscopy: quantification of inter-patient variations of fluorescence intensity

Hubert van den Bergh, Georges Wagnières, Tanja Gabrecht, Blaise Lovisa

Autofluorescence (AF) from bronchial tissue is increasingly used for the endoscopic detection of early bronchial neoplasia. Several imaging systems are commercially available, all detecting the absolute or relative AF intensity and/or spectral contrasts be ...

Springer-Verlag2009

Fluorescence cystoscopy: Perspective in clinical practice and research

Hubert van den Bergh, Georges Wagnières, Blaise Lovisa

Many studies confirm the clinical interest of photodynamic diagnostics (PDD) in non-muscle invasive bladder cancer management. PDD or fluorescence cystoscopy is not only of great value in occult urothelial cancer detection, but may have a positive impact o ...

Springer Verlag2008

Improvement of the Contrast in Cancer Detection by Autofluorescence Bronchoscopy using a narrow spectral violet Excitation: A preliminary study

Hubert van den Bergh, Georges Wagnières, Tanja Gabrecht, Blaise Lovisa

Autofluorescence (AF) bronchoscopy is a useful tool for early cancer detection. However, the mechanisms involved in this diagnosis procedure are poorly understood. We present a clinical autofluorescence imaging study to assess the depth of the principal co ...

2007

Design of an endoscopic optical reference to be used for autofluorescence bronchoscopy with a commercially available diagnostic autofluorescence endoscopy (DAFE) system

Georges Wagnières, Tanja Gabrecht, François André Borle, Blaise Lovisa

We present the design of a sterilizable optical reference to characterize and quantify the inter-patient variations in tissue autofluorescence during autofluorescence bronchoscopy with Richard Wolf's diagnostic autofluorescence endoscopy (DAFE) system. The ...

Institute of Physics2007

Autofluorescence bronchoscopy: Clinical experience with an optimized system in head and neck cancer patients

Hubert van den Bergh, Georges Wagnières, Matthieu Philippe Emmanuel Zellweger, Tanja Gabrecht, Blaise Lovisa

Elsevier2007