Nathalie Rufer

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Publications associées (4)

Transcriptomic Signature Differences Between SARS-CoV-2 and Influenza Virus Infected Patients

Nicolas Jean Philippe Guex, Nathalie Rufer, Mauro Delorenzi, Mathieu Quinodoz

2021

TIE-2-expressing monocytes are lymphangiogenic and associate specifically with lymphatics of human breast cancer

Nicolas Jean Philippe Guex, Luc Henry, Nathalie Rufer, Emanuela Marina Iancu, Hans-Anton Lehr, George Coukos, Ioannis Xenarios

In experimental mouse models of cancer, increasingly compelling evidence point toward a contribution of tumor associated macrophages (TAM) to tumor lymphangiogenesis. Corresponding experimental observations in human cancer remain scarce although lymphatic ...

Taylor & Francis Inc2016

Exhaustion of tumor-specific CD8(+) T cells in metastases from melanoma patients

Nathalie Rufer, Lukas Baitsch, Bart Deplancke, Pedro Romero, Sunil Kumar Raghav

In chronic viral infections, CD8(+) T cells become functionally deficient and display multiple molecular alterations. In contrast, only little is known of self- and tumor-specific CD8(+) T cells from mice and humans. Here we determined molecular profiles o ...

American Society for Clinical Investigation2011

Evidence for a TCR Affinity Threshold Delimiting Maximal CD8 T Cell Function

Olivier Michielin, Nathalie Rufer, Pedro Romero

Protective adaptive immune responses rely on TCR-mediated recognition of Ag-derived peptides presented by self-MHC molecules. However, self-Ag (tumor)-specific TCRs are often of too low affinity to achieve best functionality. To precisely assess the relati ...

American Association of Immunologists ; Oxford University Press2010

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