Publications de Carole Poitry-Yamate

New Insights Into Brain Energy Metabolism in Type C Hepatic Encephalopathy: A Dual 18F-FDG PET and 9.4T 1H MRS Preclinical Study

Bernard Lanz, Carole Poitry-Yamate, Cristina Ramona Cudalbu, Mario Gaetano Lepore, Dunja Simicic, Ting Yin, Jessie Julie Mosso

Lippincott Williams & Wilkins2023

Deletion of Crtc1 leads to hippocampal neuroenergetic impairments associated with depressive-like behavior

Bernard Lanz, Maria del Carmen Sandi Perez, Rolf Gruetter, Carole Poitry-Yamate, Antoine Timothée Cherix, Olivia Zanoletti, Jocelin Grosse

Mood disorders (MD) are a major burden on society as their biology remains poorly understood, challenging both diagnosis and therapy. Among many observed biological dysfunctions, homeostatic dysregulation, such as metabolic syndrome (MeS), shows considerab ...

SPRINGERNATURE2022

Quantitative FDG-PET and 1H-MRS reveal altered glucose uptake and neurometabolic profiles in BDL rats

Bernard Lanz, Carole Poitry-Yamate, Cristina Ramona Cudalbu, Mario Gaetano Lepore, Dunja Simicic, Ting Yin, Jessie Julie Mosso

SAGE PUBLICATIONS INC2022

PET CMRglc mapping and H-1-MRS show altered glucose uptake and neurometabolic profiles in BDL rats

Bernard Lanz, Carole Poitry-Yamate, Cristina Ramona Cudalbu, Mario Gaetano Lepore, Dunja Simicic, Ting Yin, Jessie Julie Mosso

Type C hepatic encephalopathy (HE) is a complex neuropsychiatric disorder occurring as a consequence of chronic liver disease. Alterations in energy metabolism have been suggested in type C HE, but in vivo studies on this matter remain sparse and have repo ...

ACADEMIC PRESS INC ELSEVIER SCIENCE2022

Excitatory/inhibitory neuronal metabolic balance in mouse hippocampus upon infusion of [U-C-13(6)]glucose

Bernard Lanz, Rolf Gruetter, Hongxia Lei, Carole Poitry-Yamate, Guillaume Donati, Antoine Timothée Cherix, Blanca Lizarbe Serra

Hippocampus plays a critical role in linking brain energetics and behavior typically associated to stress exposure. In this study, we aimed to simultaneously assess excitatory and inhibitory neuronal metabolism in mouse hippocampus in vivo by applying (18) ...

2021

Impact of aerobic exercise type on blood flow, muscle energy metabolism, and mitochondrial biogenesis in experimental lower extremity artery disease

Rolf Gruetter, Carole Poitry-Yamate

Exercise training (ET) is recommended for lower extremity artery disease (LEAD) management. However, there is still little information on the hemodynamic and metabolic adaptations by skeletal muscle with ET. We examined whether hindlimb perfusion/vasculari ...

Nature Research2020

Synchronous nonmonotonic changes in functional connectivity and white matter integrity in a rat model of sporadic Alzheimer's disease

Bernard Lanz, Carole Poitry-Yamate, Katarzyna Pierzchala, Ileana Ozana Jelescu, Ting Yin, Yujian Diao

Brain glucose hypometabolism has been singled out as an important contributor and possibly main trigger to Alzheimer's disease (AD). Intracerebroventricular injections of streptozotocin (icv-STZ) cause brain glucose hypometabolism without systemic diabetes ...

2020

The Appearance of the Warburg Effect in the Developing Avian Eye Characterized In Ovo: How Neurogenesis Can Remodel Neuroenergetics

Rolf Gruetter, Carole Poitry-Yamate, Laurent Brodier, Antoine Timothée Cherix

PURPOSE. The avian eye is an established model for exploring mechanisms that coordinate morphogenesis and metabolism during embryonic development. Less is known, however, about trafficking of bioenergetic and metabolic signaling molecules that are involved ...

2020

Evolution of the neurochemical profiles in the G93A-SOD1 mouse model of amyotrophic lateral sclerosis

Patrick Aebischer, Bernard Schneider, Rolf Gruetter, Hongxia Lei, Carole Poitry-Yamate, Elisabeth Anne Dirren

In vivo (1)H magnetic resonance spectroscopy ((1)H-MRS) investigations of amyotrophic lateral sclerosis (ALS) mouse brain may provide neurochemical profiles and alterations in association with ALS disease progression. We aimed to longitudinally follow neur ...

2019

In vivo characterization of brain metabolism by 1 H MRS, 13 C MRS and 18 FDG PET reveals significant glucose oxidation of invasively growing glioma cells

Bernard Lanz, Rolf Gruetter, Carole Poitry-Yamate, Cristina Ramona Cudalbu, Marta Lai

Glioblastoma are notorious for their highly invasive growth, diffusely infiltrating adjacent brain structures that precludes complete resection, and is a major obstacle for cure. To characterize this "invisible" tumor part, we designed a high resolution mu ...

2018

In vivo (13)C MRS in the mouse brain at 14.1 Tesla and metabolic flux quantification under infusion of [1,6-(13)C2]glucose

Bernard Lanz, Rolf Gruetter, Carole Poitry-Yamate, Cristina Ramona Cudalbu, Marta Lai, Corina Mihaela Berset

In vivo (13)C magnetic resonance spectroscopy (MRS) enables the investigation of cerebral metabolic compartmentation while, e.g. infusing (13)C-labeled glucose. Metabolic flux analysis of (13)C turnover previously yielded quantitative information of glutam ...

2018

Image-Derived Input Function from the Vena Cava for 18F-FDG PET Studies in Rats and Mice

Bernard Lanz, Rolf Gruetter, Carole Poitry-Yamate

Measurement of arterial input function is a restrictive aspect for quantitative 18F-FDG PET studies in rodents because of their small total blood volume and the related difficulties in withdrawing blood. METHODS: In the present study, we took advantage of ...

Soc Nuclear Medicine Inc2014

Experimental peripheral arterial disease: new insights into muscle glucose uptake, macrophage, and T-cell polarization during early and late stages

Rolf Gruetter, Carole Poitry-Yamate

Peripheral arterial disease (PAD) is a common disease with increasing prevalence, presenting with impaired walking ability affecting patient's quality of life. PAD epidemiology is known, however, mechanisms underlying functional muscle impairment remain un ...

2014

Direct mapping of 19F in 19FDG-6P in brain tissue at subcellular resolution using soft X-ray fluorescence

Rolf Gruetter, Carole Poitry-Yamate

Low energy x-ray fluorescence (LEXRF) detection was optimized for imaging cerebral glucose metabolism by mapping the fluorine LEXRF signal of 19 F in 19 FDG, trapped as intracellular 19 F-deoxyglucose-6-phosphate ( 19 FDG-6P) at 1μm spatial resolution from ...

2013

Hepatic glucose sensing is required to preserve β cell glucose competence

Bernard Lanz, Rolf Gruetter, Carole Poitry-Yamate, Frédéric Schütz

Liver glucose metabolism plays a central role in glucose homeostasis and may also regulate feeding and energy expenditure. Here we assessed the impact of glucose transporter 2 (Glut2) gene inactivation in adult mouse liver (LG2KO mice). Loss of Glut2 suppr ...

Amer Soc Clinical Investigation Inc2013

Feasibility of direct mapping of cerebral fluorodeoxy-D-glucose metabolism in situ at subcellular resolution using soft X-ray fluorescence

Rolf Gruetter, Vincent Gajdosik, Carole Poitry-Yamate, Mario Gaetano Lepore

Glucose metabolism is difficult to image with cellular resolution in mammalian brain tissue, particularly with (18) fluorodeoxy-D-glucose (FDG) positron emission tomography (PET). To this end, we explored the potential of synchrotron-based low-energy X-ray ...

Wiley-Blackwell2013

Direct mapping of FDG uptake in situ at subcellular resolution using soft X-ray fluorescence

Rolf Gruetter, Carole Poitry-Yamate

Wiley-Blackwell2013

Bioavailable copper modulates oxidative phosphorylation and growth of tumors

Carole Poitry-Yamate, Johan Auwerx, Pénélope Andreux, Douglas Hanahan, Seiko Ishida

Copper is an essential trace element, the imbalances of which are associated with various pathological conditions, including cancer, albeit via largely undefined molecular and cellular mechanisms. Here we provide evidence that levels of bioavailable copper ...

National Academy of Sciences2013

GLIAL GLYCOLYTIC GAPDH ACTIVITY MODULATES THE RESTING CEREBRAL METABOLIC RATE OF GLUCOSE AND CA+2- DEPENDENT EXCITATORY NEUROTRANSMITTER RELEASE

Giorgio Margaritondo, Bernard Lanz, Rolf Gruetter, Carole Poitry-Yamate, Laurent Lecomte

2011

68Ga-NODAGA-RGDyK for αvβ3 integrin PET imaging. Preclinical investigation and dosimetry

Serge Baechler, David Viertl, Carole Poitry-Yamate, Christian Rüegg

To visualize neovasculature and/or tumour integrin αvβ3 we selected the binding moiety Arg-Gly-Asp-D-Tyr-Lys (RGDyK) coupled to NODAGA for labeling with 68Ga. ...

Schattauer2011