Publications de Rodrigo Manuel Gonzalez

ClimateBench v1.0: A Benchmark for Data-Driven Climate Projections

Many different emission pathways exist that are compatible with the Paris climate agreement, and many more are possible that miss that target. While some of the most complex Earth System Models have simulated a small selection of Shared Socioeconomic Pathw ...

AMER GEOPHYSICAL UNION2022

OprD Repression upon Metal Treatment Requires the RNA Chaperone Hfq in Pseudomonas aeruginosa

Rodrigo Manuel Gonzalez, Tiziana Scrignari

The metal-specific CzcRS two-component system in Pseudomonas aeruginosa is involved in the repression of the OprD porin, causing in turn carbapenem antibiotic resistance in the presence of high zinc concentration. It has also been shown that CzcR is able t ...

Mdpi Ag2016

Monalysin, a novel ß-pore-forming toxin from the Drosophila pathogen Pseudomonas entomophila, contributes to host intestinal damage and lethality

Françoise Gisou van der Goot Grunberg, Mircea Ioan Iacovache, Rodrigo Manuel Gonzalez, Bruno Lemaitre, Onya Opota

Pseudomonas entomophila is an entomopathogenic bacterium that infects and kills Drosophila. P. entomophila pathogenicity is linked to its ability to cause irreversible damages to the Drosophila gut, preventing epithelium renewal and repair. Here we report ...

2011

Pore-forming toxins induce multiple cellular responses promoting survival

Mirko Bischofberger, Françoise Gisou van der Goot Grunberg, Rodrigo Manuel Gonzalez, Sylvia Ho

Pore-forming toxins (PFTs) are secreted proteins that contribute to the virulence of a great variety of bacterial pathogens. They inflict one of the more disastrous damages a target cell can be exposed to: disruption of plasma membrane integrity. Since thi ...

Wiley-Blackwell2011

Cellular Responses to Bacterial Pore-Forming Toxins

Rodrigo Manuel Gonzalez

Pore-forming toxins (PFTs) represent the largest class of bacterial protein toxins and constitute major virulence factors produced by pathogenic bacteria during infection. Pore formation appears to be an ancient form of attack, which is also found in hydro ...

EPFL2011

Bacterial pore-forming toxins: the (w)hole story?

Mirko Bischofberger, Françoise Gisou van der Goot Grunberg, Rodrigo Manuel Gonzalez

Pore-forming toxins (PFTs) are the most common class of bacterial protein toxins and constitute important bacterial virulence factors. The mode of action of PFT is starting to be better understood. In contrast, little is known about the cellular response t ...

Birkhäuser-Verlag, Springer2008