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Sean Lewis Hill

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Publications associées (41)

Large-scale extraction of brain connectivity from the neuroscientific literature

Jean-Cédric Chappelier, Sean Lewis Hill, Martin Telefont, Renaud Luc Richardet

In neuroscience, as in many other scientific domains, the primary form of knowledge dissemination is through published articles. One challenge for modern neuroinformatics is finding methods to make the knowledge from the tremendous backlog of publications ...

Oxford Univ Press2015

The Resource Identification Initiative: A cultural shift in publishing

Sean Lewis Hill

A central tenet in support of research reproducibility is the ability to uniquely identify research resources, i.e., reagents, tools, and materials that are used to perform experiments. However, current reporting practices for research resources are insuff ...

2015

Reconstruction and Simulation of Neocortical Microcircuitry

Nenad Buncic, Jean-Vincent Le Bé, Selim Arsever, Henry Markram, Gilad Silberberg, Sébastien Lasserre, Vincent Delattre, Raphael Dumusc, Rodrigo de Campos Perin, Imad Riachi, Thomas Berger, Felix Schürmann, James Gonzalo King, Rajnish Ranjan, Srikanth Ramaswamy, Michael Lee Hines, Sean Lewis Hill, Juan Bautista Hernando Vieites, Georges Khazen, Shruti Muralidhar, Anastasia Ailamaki, Eilif Benjamin Muller, Farhan Tauheed, Jean Pierre Ghobril, Julie Meystre, Daniel Keller, Idan Segev, Michael Reimann, Thomas Heinis, John Richard Walker, Martin Telefont, Yun Wang, Ying Shi, Joseph William Graham, Marwan Muhammad Ahmed Abdellah, Julian Charles Shillcock, Jean-Denis Georges Emile Courcol, Ahmet Bilgili, Werner Alfons Hilda Van Geit, Athanassia Chalimourda, , , , , , , , , , , , , , , , , , , , , , , , , , , ,

Feeding the human brain model

Sean Lewis Hill

The goal of the Human Brain Project is to develop, during the next decade, an infrastructure capable of simulating a draft human brain model based on available experimental data. One of the key issues is therefore to integrate and make accessible the exper ...

Elsevier2015

Automatic target validation based on neuroscientific literature mining for tractography

Jean-Cédric Chappelier, Sean Lewis Hill, Renaud Luc Richardet, David Slater, Xavier Vasques, Bogdan Draganski, Jocelyne Bloch

Target identification for tractography studies requires solid anatomical knowledge validated by an extensive literature review across species for each seed structure to be studied. Manual literature review to identify targets for a given seed region is ted ...

Frontiers Research Foundation2015

BigNeuron: Large-Scale 3D Neuron Reconstruction from Optical Microscopy Images

Sean Lewis Hill

Understanding the structure of single neurons is critical for understanding how they function within neural circuits. BigNeuron is a new community effort that combines modern bioimaging informatics, recent leaps in labeling and microscopy, and the widely r ...

Elsevier2015

The neocortical microcircuit collaboration portal: a resource for rat somatosensory cortex

Selim Arsever, Henry Markram, Raphael Dumusc, Felix Schürmann, James Gonzalo King, Rajnish Ranjan, Srikanth Ramaswamy, Sean Lewis Hill, Juan Bautista Hernando Vieites, Eilif Benjamin Muller, Daniel Keller, Idan Segev, Michael Reimann, John Richard Walker, Martin Telefont, Yun Wang, Ying Shi, Joseph William Graham, Marwan Muhammad Ahmed Abdellah, Julian Charles Shillcock, Jean-Denis Georges Emile Courcol, Ahmet Bilgili, Werner Alfons Hilda Van Geit, Athanassia Chalimourda, Stefan Eilemann, Guy Antoine Atenekeng Kahou, Jeffrey Christopher Muller, Lida Kanari, Stefano Zaninetta, Giuseppe Chindemi, Jafet Villafranca Diaz, Yury Brukau, Michael Emiel Gevaert, Stanislaw Ryszard Adaszewski, Nicolas Antille

We have established a multi-constraint, data-driven process to digitally reconstruct, and simulate prototypical neocortical microcircuitry, using sparse experimental data. We applied this process to reconstruct the microcircuitry of the somatosensory corte ...

2015

A Biophysically Detailed Model of Neocortical Local Field Potentials Predicts the Critical Role of Active Membrane Currents

Henry Markram, Rodrigo de Campos Perin, Sean Lewis Hill, Michael Reimann

Brain activity generates extracellular voltage fluctuations recorded as local field potentials (LFPs). It is known that the relevant microvariables, the ionic currents across membranes, jointly generate the macrovariables, the extracellular voltage, but ne ...

Elsevier2013

New insights into the classification and nomenclature of cortical GABAergic interneurons

Henry Markram, Jean Rossier, Sean Lewis Hill, Yun Wang, Zoltan Kisvarday, Ruth Benavides Piccione

A systematic classification and accepted nomenclature of neuron types is much needed but is currently lacking. This article describes a possible taxononnical solution for classifying GABAergic interneurons of the cerebral cortex based on a novel, web-based ...

Nature Publishing Group2013

A Hierarchical Structure of Cortical Interneuron Electrical Diversity Revealed by Automated Statistical Analysis

Henry Markram, Felix Schürmann, Sean Lewis Hill, Idan Segev

Although the diversity of cortical interneuron electrical properties is well recognized, the number of distinct electrical types (e-types) is still a matter of debate. Recently, descriptions of interneuron variability were standardized by multiple laborato ...

Oxford University Press2013

Computational Neuroscience Ontology: a new tool to provide semantic meaning to your models

Sean Lewis Hill

The diversity of modeling approaches in computational neuroscience makes model sharing, retrieval, reuse and reproducibility difficult and even sometimes impossible. To address this problem, standardized languages have been developed by and for the communi ...

2012

A neuron membrane mesh representation for visualization of electrophysiological simulations

Henry Markram, Sébastien Lasserre, Felix Schürmann, Sean Lewis Hill, Juan Bautista Hernando Vieites

We present a process to automatically generate three-dimensional mesh representations of the complex, arborized cell membrane surface of cortical neurons (the principal information processing cells of the brain) from nonuniform morphological measurements. ...

Institute of Electrical and Electronics Engineers2012

Models of neocortical layer 5b pyramidal cells capturing a wide range of dendritic and perisomatic active properties

Henry Markram, Felix Schürmann, Sean Lewis Hill, Idan Segev

The thick-tufted layer 5b pyramidal cell extends its dendritic tree to all six layers of the mammalian neocortex and serves as a major building block for the cortical column. L5b pyramidal cells have been the subject of extensive experimental and modeling ...

2011

NineML: the network interchange for neuroscience modeling language

Michael Lee Hines, Sean Lewis Hill, Eilif Benjamin Muller

The growing number of large-scale neuronal network models has created a need for standards and guidelines to ease model sharing and facilitate the replication of results across different simulators. To foster community efforts towards such standards, the I ...

2011

Effective Stimuli for Constructing Reliable Neuron Models

Henry Markram, Thomas Berger, Felix Schürmann, Sean Lewis Hill, Idan Segev

The rich dynamical nature of neurons poses major conceptual and technical challenges for unraveling their nonlinear membrane properties. Traditionally, various current waveforms have been injected at the soma to probe neuron dynamics, but the rationale for ...

2011

Modeling the effects of midazolam on cortical and thalamic neurons

Sean Lewis Hill

Controversy exists regarding the site where anesthetics act in the brain to produce sedation and unconsciousness. Actions in the cerebral cortex and thalamus are likely, although the relative importance of each site is unclear. We used in computo modeling ...

2009

Modeling the Gabaergic Action of Etomidate on the Thalamocortical System

Sean Lewis Hill

BACKGROUND: We have used a computational model of the thalamocortical system to investigate the effects of a GABAergic anesthetic (etomidate) on cerebral cortical and thalamic neuronal function. We examined the effects of phasic an tonic inhibition, as wel ...

2009

A Component-Based Extension Framework for Large-Scale Parallel Simulations in NEURON

Henry Markram, Felix Schürmann, Michael Lee Hines, Sean Lewis Hill

As neuronal simulations approach larger scales with increasing levels of detail, the neurosimulator software represents only a part of a chain of tools ranging from setup, simulation, interaction with virtual environments to analysis and visualizations. Pr ...

2009

Breakdown of Effective Connectivity During Slow Wave Sleep: Investigating the Mechanism Underlying a Cortical Gate Using Large-Scale Modeling

Sean Lewis Hill

Esser SK, Hill S, Tononi G. Breakdown of effective connectivity during slow wave sleep: investigating the mechanism underlying a cortical gate using large-scale modeling. J Neurophysiol 102: 2096-2111, 2009. First published August 5, 2009; doi: 10.1152/jn. ...

2009

Sleep improves the variability of motor performance

Sean Lewis Hill

Sleep after learning often enhances task performance, but the underlying mechanisms remain unclear. Using a well-characterized rotation learning paradigm implemented both behaviorally and in computer simulations, we compared two main hypotheses: the first, ...

2008

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Keerthan Muthurasa

Stefan Eilemann

Guy Antoine Atenekeng Kahou

Jeffrey Christopher Muller

Carlos Aguado Sanchez

Jafet Villafranca Diaz

Aleksandr Ovcharenko

Juan Luis Riquelme Roman

Benjamin Roy Morrice

James Alexander Dynes

Michael Emiel Gevaert

Juan Pablo Palacios

Pramod Shivaji Kumbhar

Ricardo Manuel Salgueiro Domingues Da Silva

Max Christian Nolte

Zoltan Kisvarday

Nicolas Antille

Lidia Alonso-Nanclares

Taylor Howard Newton

Alberto Munoz Cespedes

Anirudh Gupta

Michael John Kenyon

We present a first-draft digital reconstruction of the microcircuitry of somatosensory cortex of juvenile rat. The reconstruction uses cellular and synaptic organizing principles to algorithmically reconstruct detailed anatomy and physiology from sparse ex ...

Elsevier2015

Frontiers Research Foundation