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Mauro Delorenzi

Cette personne n’est plus à l’EPFL

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Publications associées (38)

Genome-Wide RNA Polymerase II Profiles and RNA Accumulation Reveal Kinetics of Transcription and Associated Epigenetic Changes During Diurnal Cycles

Felix Naef, Nicolas Jean Philippe Guex, Olivier Martin, Mauro Delorenzi, Nouria Hernandez, Bart Deplancke, Jacques Rougemont, Laura Symul, Winship Herr

Interactions of cell-autonomous circadian oscillators with diurnal cycles govern the temporal compartmentalization of cell physiology in mammals. To understand the transcriptional and epigenetic basis of diurnal rhythms in mouse liver genome-wide, we gener ...

Public Library Science2012

Breast cancer suppressor candidate-1 (BCSC-1) is a melanoma tumor suppressor that down regulates MITF

Mauro Delorenzi

Understanding the molecular aberrations involved in the development and progression of metastatic melanoma (MM) is essential for a better diagnosis and targeted therapy. We identified breast cancer suppressor candidate-1 (BCSC-1) as a novel tumor suppresso ...

2012

Pathway Analysis of Glioblastoma Tissue after Preoperative Treatment with the EGFR Tyrosine Kinase Inhibitor Gefitinib-A Phase II Trial

Mauro Delorenzi

Amplification of the epidermal growth factor receptor (EGFR) gene is one of the most common oncogenic alterations in glioblastoma (45%) making it a prime target for therapy. However, small molecule inhibitors of the EGFR tyrosine kinase showed disappointin ...

2011

The Wnt inhibitory factor 1 (WIF1) is targeted in glioblastoma and has a tumor suppressing function potentially by induction of senescence

Mauro Delorenzi

Gene expression-based prediction of genomic copy number aberrations in the chromosomal region 12q13 to 12q15 that is flanked by MDM2 and CDK4 identified Wnt inhibitory factor 1 (WIF1) as a candidate tumor suppressor gene in glioblastoma. WIF1 encodes a sec ...

2011

Rgtsp: a generalized top scoring pairs package for class prediction

Vlad Popovici, Mauro Delorenzi

A top scoring pair (TSP) classifier consists of a pair of variables whose relative ordering can be used for accurately predicting the class label of a sample. This classification rule has the advantage of being easily interpretable and more robust against ...

Oxford University Press2011

Bcl9/Bcl9l are critical for Wnt-mediated regulation of stem cell traits in colon epithelium and adenocarcinomas

Michel Aguet, Mauro Delorenzi, Norbert Wiedemann, Sylvie André Baflast, Pascale Anderle Pedone

Canonical Wnt signaling plays a critical role in stem cell maintenance in epithelial homeostasis and carcinogenesis. Here, we show that in the mouse this role is critically mediated by Bcl9/Bcl9l, the mammalian homologues of Legless, which in Drosophila is ...

American Association for Cancer Research2010

The MicroArray Quality Control (MAQC)-II study of common practices for the development and validation of microarray-based predictive models

Vlad Popovici, Jun Luo, Darlene Goldstein, Mauro Delorenzi, Lu Meng, Li Li, Li Zhang, Wen Luo, Li Guo, Jonathan Koh Boon Han, Wei Wang, Rui Jiang, Jie Liu, Ying Liu, Chenxu Zhao, Rong Chen

Gene expression data from microarrays are being applied to predict preclinical and clinical endpoints, but the reliability of these predictions has not been established. In the MAQC-II project, 36 independent teams analyzed six microarray data sets to gene ...

Nature Publishing Group2010

Effect of training-sample size and classification difficulty on the accuracy of genomic predictors

Vlad Popovici, Mauro Delorenzi

Introduction: As part of the MicroArray Quality Control (MAQC)-II project, this analysis examines how the choice of univariate feature-selection methods and classification algorithms may influence the performance of genomic predictors under varying degrees ...

2010

Relationship between estrogen receptor alpha location and gene induction reveals the importance of downstream sites and cofactors

Felix Naef, Mauro Delorenzi

BACKGROUND: To understand cancer-related modifications to transcriptional programs requires detailed knowledge about the activation of signal-transduction pathways and gene expression programs. To investigate the mechanisms of target gene regulation by hum ...

BioMed Central2009

Method for predicting the efficacy of cancer therapy

Mauro Delorenzi

The present invention relates to a method and a kit for predicting the efficacy of cancer therapy in a subject who has undergone or is undergoing chemotherapy treatment for cancer. ...

2009

Selecting control genes for RT-QPCR using public microarray data

Vlad Popovici, Darlene Goldstein, Mauro Delorenzi

Background: Gene expression analysis has emerged as a major biological research area, with real-time quantitative reverse transcription PCR (RT-QPCR) being one of the most accurate and widely used techniques for expression profiling of selected genes. In o ...

2009

Cross-species and cross-platform gene expression studies with the Bioconductor-compliant R package 'annotationTools'

Mauro Delorenzi

BACKGROUND: The variety of DNA microarray formats and datasets presently available offers an unprecedented opportunity to perform insightful comparisons of heterogeneous data. Cross-species studies, in particular, have the power of identifying conserved, f ...

BioMed Central2008

Comprehensive spatiotemporal transcriptomic analyses of the ganglionic eminences demonstrate the uniqueness of its caudal subdivision

Didier Surdez, Susan Willi Monnerat, Mauro Delorenzi

The elucidation of mechanisms underlying telencephalic neural development has been limited by the lack of knowledge regarding the molecular and cellular aspects of the ganglionic eminence (GE), an embryonic structure that supplies the brain with diverse se ...

Elsevier2008

Meta-analysis of gene expression profiles in breast cancer: toward a unified understanding of breast cancer subtyping and prognosis signatures

Thierry Sengstag, Darlene Goldstein, Benjamin Haibe-Kains, Mauro Delorenzi

Introduction Breast cancer subtyping and prognosis have been studied extensively by gene expression profiling, resulting in disparate signatures with little overlap in their constituent genes. Although a previous study demonstrated a prognostic concordance ...

2008

Leukaemia cell lines are robust in vitro models - response to MacLeod & Drexler

Mauro Delorenzi

2008

Analysis of potential transcriptomic biomarkers for Huntington's disease in peripheral blood

Heike Runne, Mauro Delorenzi

Highly quantitative biomarkers of neurodegenerative disease remain an important need in the urgent quest for disease-modifying therapies. For Huntington's disease (HD), a genetic test is available (trait marker), but necessary state markers are still in de ...

National Academy of Sciences2007

Mutant huntingtin's effects on striatal gene expression in mice recapitulate changes observed in human Huntington's disease brain and do not differ with mutant huntingtin length or wild-type huntingtin dosage

Thierry Sengstag, Darlene Goldstein, Mauro Delorenzi

To test the hypotheses that mutant huntingtin protein length and wild-type huntingtin dosage have important effects on disease-related transcriptional dysfunction, we compared the changes in mRNA in seven genetic mouse models of Huntington's disease (HD) a ...

Oxford University Press2007

Regional and cellular gene expression changes in human Huntington's disease brain

Thierry Sengstag, Darlene Goldstein, Mauro Delorenzi, Doris Chau Voo Thu

Huntington's disease (HD) pathology is well understood at a histological level but a comprehensive molecular analysis of the effect of the disease in the human brain has not previously been available. To elucidate the molecular phenotype of HD on a genome- ...

Oxford University Press2006

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