Publications de Katarzyna Mosiewicz

Microscale patterning of hydrogel stiffness through light-triggered uncaging of thiols

Matthias Lütolf, Katarzyna Mosiewicz, Laura Kolb

Mammalian cell behavior is strongly influenced by physical and chemical cues originating from the extracellular matrix (ECM). In vivo, ECM signals are displayed in a spatiotemporally complex fashion, often composed as gradients and in concentration profile ...

Royal Soc Chemistry2014

3D niche microarrays for systems-level analyses of cell fate

Matthias Lütolf, Katarzyna Mosiewicz, Adrian Ranga, Samy Gobaa, Andrea Negro, Yuya Okawa

The behaviour of mammalian cells in a tissue is governed by the three-dimensional (3D) microenvironment and involves a dynamic interplay between biochemical and mechanical signals provided by the extracellular matrix (ECM), cell–cell interactions and solub ...

Nature Publishing Group2014

In situ cell manipulation through enzymatic hydrogel photopatterning

Matthias Lütolf, Mikaël Martino, Jeffrey Alan Hubbell, Katarzyna Mosiewicz, Martin Ehrbar, Laura Kolb

The physicochemical properties of hydrogels can be manipulated in both space and time through the controlled application of a light beam. However, methods for hydrogel photopatterning either fail to maintain the bioactivity of fragile proteins and are thus ...

Nature Publishing Group2013

Photopatterning of Synthetic Hydrogels

Katarzyna Mosiewicz

In recent years sophisticated biomaterials have made a significant impact on our understanding of cellular behavior, particularly in the fields of stem cell research and tissue engineering. Nevertheless, the promising potential of stem cells for regenerati ...

EPFL2012

Elucidating the Role of Matrix Stiffness in 3D Cell Migration and Remodeling

Matthias Lütolf, Katarzyna Mosiewicz, Adrian Ranga, Philipp Sebastian Lienemann, Martin Ehrbar

Reductionist in vitro model systems which mimic specific extracellular matrix functions in a highly controlled manner, termed artificial extracellular matrices (aECM), have increasingly been used to elucidate the role of cell-ECM interactions in regulating ...

Elsevier2011

Method of crosslinking two objects of interest

Kai Johnsson, Christopher Chidley, Katarzyna Mosiewicz

The invention provides a method of crosslinking two objects of interest, comprising the steps of : i) providing a fusion protein comprising at least a first protein and a second protein, wherein both the first and the second protein are, based on their str ...

2008

A designed protein for the specific and covalent hetero-conjugation of biomolecules

Kai Johnsson, Christopher Chidley, Katarzyna Mosiewicz

2008