Publications de Nathalie Just | EPFL Graph Search

Astrocytic and neuronal oxidative metabolism are coupled to the rate of glutamate-glutamine cycle in the tree shrew visual cortex

Rolf Gruetter, João Miguel das Neves Duarte, Nathalie Just, Sarah Catherine Sonnay, Anne Catherine Clerc, Gregor Rainer

Astrocytes play an important role in glutamatergic neurotransmission, namely by clearing synaptic glutamate and converting it into glutamine that is transferred back to neurons. The rate of this glutamate–glutamine cycle (VNT) has been proposed to couple t ...

Wiley-Blackwell2018

Coupling of the glutamate-glutamine cycle rate with both glial and neuronal oxidative metabolism in the visual cortex of the Tupaia belangeri

Rolf Gruetter, João Miguel das Neves Duarte, Nathalie Just, Sarah Catherine Sonnay, Anne Catherine Clerc

Sage Publications Inc2017

Investigating the Role of Glutamate and GABA in the Modulation of Transthalamic Activity: A Combined fMRI-fMRS Study

Nathalie Just, Sarah Catherine Sonnay

The Excitatory-Inhibitory balance (EIB) between glutamatergic and GABAergic neurons is known to regulate the function of thalamocortical neurocircuits. The thalamus is known as an important relay for glutamatergic and GABAergic signals ascending/descending ...

Frontiers Media Sa2017

Energy metabolism in the rat cortex under thiopental anaesthesia measured

Rolf Gruetter, João Miguel das Neves Duarte, Nathalie Just, Sarah Catherine Sonnay

Barbiturates, commonly used as general anaesthetics, depress neuronal activity and thus cerebral metabolism. Moreover, they are likely to disrupt the metabolic support of astrocytes to neurons, as well as the uptake of nutrients from circulation. By employ ...

Wiley-Blackwell2017

Lactate and Glutamate dynamics during prolonged stimulation of the rat barrel cortex suggest adaptation of cerebral glucose and oxygen metabolism

João Miguel das Neves Duarte, Nathalie Just, Sarah Catherine Sonnay

A better understanding of BOLD responses stems from a better characterization of the brain’s ability to metabolize glucose and oxygen. Non-invasive techniques such as functional magnetic resonance spectroscopy (fMRS) have thus been developed allowing for t ...

Elsevier2017

T1 mapping of the mouse brain following fractionated manganese administration using MP2RAGE

Florent Eggenschwiler, Nathalie Just, Carola Jaquelina del Carmen Romero, Luc Driencourt, Mario Gaetano Lepore, Olivier Benoit Thomas Reynaud

With the increasing development of transgenic mouse models of neurodegenerative diseases allowing improved understanding of the underlying mechanisms of these disorders, robust quantitative mapping techniques are also needed in rodents. MP2RAGE has shown g ...

Springer Heidelberg2017

Rates oxidative metabolism in astrocytes and neurons are coupled to the glutamate-glutamine cycle in the tree shrew visual cortex

Rolf Gruetter, João Miguel das Neves Duarte, Nathalie Just, Sarah Catherine Sonnay, Anne Catherine Clerc

Wiley2017

Compartmentalised energy metabolism supporting glutamatergic neurotransmission in response to increased activity in the rat cerebral cortex: A 13C MRS study in vivo at 14.1 T

Rolf Gruetter, João Miguel das Neves Duarte, Nathalie Just, Sarah Catherine Sonnay

Many tissues exhibit metabolic compartmentation. In the brain, while there is no doubt on the importance of functional compartmentation between neurons and glial cells, there is still debate on the specific regulation of pathways of energy metabolism at di ...

Nature Publishing Group2016

Effects of paternal and peripubertal stress on aggression, anxiety, and metabolic alterations in the lateral septum

Maria del Carmen Sandi Perez, Maria Isabel Cordero Campana, Nathalie Just, Guillaume Poirier

Early-life stress and biological predispositions are linked to mood and personality disorders related to aggressive behavior. We previously showed that exposure to peripubertal stress leads to increased anxiety-like behaviors and aggression against males a ...

2016

Imaging of prolonged BOLD response in the somatosensory cortex of the rat

Rolf Gruetter, João Miguel das Neves Duarte, Nathalie Just, Sarah Catherine Sonnay

Blood oxygenation level-dependent (BOLD) functional MRI is a widely employed methodology in experimental and clinical neuroscience, although its nature is not fully understood. To gain insights into BOLD mechanisms and take advantage of the new functional ...

Wiley-Blackwell2015

Energy metabolism in the rat cortex under deep thiopental anesthesia measured in vivo by 13C MRS at 14.1 T

Rolf Gruetter, João Miguel das Neves Duarte, Nathalie Just, Sarah Catherine Sonnay

Wiley-Blackwell2015

Improving tumor heterogeneity MRI assessment with histograms

Nathalie Just

By definition, tumours are heterogeneous. They are defined by marked differences in cells, microenvironmental factors (oxygenation levels, pH, VEGF, VPF and TGF-α) metabolism, vasculature, structure and function that in turn translate into heterogeneous dr ...

Nature Publishing Group2014

Characterization of sustained BOLD activation in the rat barrel cortex and Neurochemical consequences

Rolf Gruetter, Lijing Xin, Hanne Frenkel, Nathalie Just

To date, only a couple of functional MR spectroscopy (fMRS) studies were conducted in rats. Due to the low temporal resolution of 1H-MRS techniques, prolonged stimulation paradigms are necessary for investigating the metabolic outcome in the rat brain duri ...

Elsevier2013

Histogram Analysis of the Microvasculature of Intracerebral Human and Murine Glioma Xenografts

Nathalie Just

The purpose of this study is to examine the usefulness of histogram analysis combined with vessel size index (VSI) magnetic resonance imaging for the specific characterization of brain tumor microvasculature in a panel of six volume-matched glioma xenograf ...

Wiley-Blackwell2011

Effect of manganese chloride on the neurochemical profile of the rat hypothalamus

Rolf Gruetter, Hongxia Lei, Nathalie Just, Cristina Ramona Cudalbu

Manganese (Mn 2+)-enhanced magnetic resonance imaging studies of the neuronal pathways of the hypothalamus showed that information about the regulation of food intake and energy balance circulate through specific hypothalamic nuclei. The dehydration-induce ...

Nature Publishing Group2011

Detection of neuronal activity and metabolism in a model of dehydration-induced anorexia in rats at 14.1T using manganese-enhanced MRI and 1H MRS

Rolf Gruetter, Nathalie Just

In this study, hypothalamic activation was performed by dehydration-induced anorexia (DIA) and overnight food suppression (OFS) in female rats. The assessment of the hypothalamic response to these challenges by manganese-enhanced MRI showed increased neuro ...

Wiley-Blackwell2011

Assessment of the effect of haematocrit-dependent arterial input functions on the accuracy of pharmacokinetic parameters in dynamic contrast-enhanced MRI

Nathalie Just

The detection and prognosis of prostate cancer in its early stages are critically important. It is therefore essential to improve the existing dynamic contrast-enhanced MRI (DCE MRI) techniques commonly used for the assessment of the tumour vascular enviro ...

Wiley-Blackwell2011

BOLD responses to trigeminal nerve stimulation

Carl Petersen, Rolf Gruetter, Nathalie Just

The current study investigates a new model of barrel cortex activation using stimulation of the infraorbital branch of the trigeminal nerve. A robust and reproducible activation of the rat barrel cortex was obtained following trigeminal nerve stimulation. ...

2010

Minimization of Nyquist ghosting for echo-planar imaging at ultra-high fields based on a "negative readout gradient" strategy

Rolf Gruetter, Hongxia Lei, Nathalie Just, Wietske Van der Zwaag, Tobias Kober, José Pedro Rebelo Ferreira Marques

Purpose: To improve the traditional Nyquist ghost correction approach in echo planar imaging (EPI) at high fields, via schemes based on the reversal of the EPI readout gradient polarity for every other volume throughout a functional magnetic resonance imag ...

Wiley-Blackwell2009

Fast Bias Field Correction for 9.4 Tesla Magnetic Resonance Imaging

Murat Kunt, Jean-Philippe Thiran, Meritxell Bach Cuadra, Nicolas Kunz, Rolf Gruetter, Nathalie Just, Xavier Pena Pina

In this paper the problem of intensity inhomogeneity at high magnetic field on magnetic resonance images is addressed. Specifically, rat brain images at 9.4T acquired with a surface coil are bias corrected. We propose a low- pass frequency model that takes ...

2008