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Christian Hartinger

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Publications associées (53)

Characterization of Platinum Anticancer Drug Protein-Binding Sites Using a Top-Down Mass Spectrometric Approach

Paul Joseph Dyson, Yury Tsybin, Christian Hartinger

A proof-of-principle study on the application of a top-down electrospray ionization Fourier transform ion cyclotron resonance mass spectrometric approach for characterization of the primary binding sites of the platinum anticancer agents cisplatin, transpl ...

2008

Linked Metal-cluster Systems: Isolation and Characterization of {anti-[(p-cymene)RuCl]-m-[k 2-P,P';k 1-P''-(PPh2CH2)3CMe]-[AuPt3(CO)3(PCy3)3]}(PF6)2

Hisham Ben Hamidane, Zoltan Beni, Rosario Scopelliti, Paul Joseph Dyson, Andrew Douglas Phillips, Christian Hartinger

The new mixed-metal complex {anti-[(p-cymene)RuCl]-m-[k 2-P,P';k 1-P''-(PPh2CH2)3CMe]-[AuCl]}PF6 and its cluster deriv. {anti-[(p-cymene)RuCl]-m-[k 2-P,P';k 1-P''-(PPh2CH2)3CMe]-[AuPt3(CO)3(PCy3)3]}(PF6)2 have been prepd. and characterized. Notably, NMR sp ...

Springer US2008

CZE-ICP-MS as a tool for studying the hydrolysis of ruthenium anticancer drug candidates and their reactivity towards the DNA model compound dGMP

Paul Joseph Dyson, Christian Hartinger, Michael Groessl

Elucidating the mode of action and thereby opening the way to the design of chemotherapeutic agents is one of the major goals of metal-based anticancer research. Hydrolysis and DNA binding play an important role for pharmaceutical formulation and for exert ...

2008

KP1019, a new redox-active anticancer agent - preclinical development and results of a clinical phase I study in tumor patients

Paul Joseph Dyson, Christian Hartinger, Michael Groessl

A review. The promising drug candidate indazolium trans-[tetrachlorobis(1H-indazole)ruthenate(III)] (KP1019) is the second Ru-based anticancer agent to enter clin. trials. In this review, which is an update of a paper from 2006, the exptl. evidence for the ...

2008

The Hydration of Chloroacetonitriles Catalyzed by Mono- and Dinuclear Ru-II- and Os-II-Arene Complexes

Christian Hartinger, Alexey Nazarov

The hydration of nitrites to the corresponding amides is all important reaction for both laboratory and industry purposes. The classical synthesis method requires harsh conditions, gives low yields, and is nonselective due to further hydrolysis of the amid ...

2008

Phosphite-derivatized ruthenium-carbohydrate complexes in the catalytic hydration of nitriles

Christian Hartinger, Alexey Nazarov

The synthesis of metal complexes with bioligands is one option to introduce chirally defined ligands to catalysts. Herein, file hydration of nitriles to the corresponding carboxamides by use of ruthenium(H) complexes is described, which were obtained by at ...

2008

Stability of an organometallic ruthenium-ubiquitin adduct in the presence of glutathione: Relevance to antitumor activity

Paul Joseph Dyson, Céline Rita Duhot, Yury Tsybin, Christian Hartinger, Angela Casini

The interactions of the ruthenium(II) complex Ru(η6-p-cymene)(pta)Cl2 (RAPTA-C), an effective anticancer and antimetastatic agent, with biol. nucleophiles are important with respect to its mechanism of action, for example, the reaction with glutathione (GS ...

2008

Hydrolysis study of the bifunctional antitumor compound RAPTA-C, [Ru(η6-p-cymene)Cl2(pta)]

Paul Joseph Dyson, Claudine Scolaro, Christian Hartinger, Claire Samantha Allardyce

The hydrolysis of [Ru(η6-p-cymene)Cl2(PTA)] (PTA = 1,3,5-triaza-7-phosphatricyclo-[3.3.1.1]decanephosphine; RAPTA-C) was studied using UV-visible (UV-vis) spectrophotometry and NMR spectroscopy. In analogy to in silico studies, [Ru(η6-p-cymene)Cl(H2O)(PTA) ...

2008

Elucidation of the interactions of an anticancer ruthenium complex in clinical trials with biomolecules utilizing capillary electrophoresis hyphenated to inductively coupled plasma-mass spectrometry

Paul Joseph Dyson, Christian Hartinger, Michael Groessl

The application of capillary electrophoresis (CE) combined with highly sensitive inductively-coupled-plasma mass spectrometric (ICP-MS) detection allows the interactions of metal complexes with biomols. to be characterized. This technique has been used to ...

2008

Influence of the Spacer Length on the in Vitro Activity of Dinuclear Ruthenium-Arene Compounds

Kay Severin, Christian Hartinger, Alexey Nazarov

2008

Modifying the Structure of Dinuclear Ruthenium Complexes with Antitumor Activity

Kay Severin, Christian Hartinger, Alexey Nazarov

2008

Mass spectrometric analysis of ubiquitin-platinum interactions of leading anticancer drugs: MALDI versus ESI

Paul Joseph Dyson, Wee Han Ang, Christian Hartinger, Angela Casini

The protein binding of anticancer metallodrugs is regarded as an important part in their mode of action both for delivering the active moiety into the tumor but also being responsible for deactivation and/or unwanted side effects. Characterization of prote ...

2007

Tuning the hydrophobicity of ruthenium(II)-arene (RAPTA) drugs to modify uptake, biomolecular interactions and efficacy

Paul Joseph Dyson, Claudine Scolaro, Christian Hartinger, Gianni Sava

The antitumor activity of the organometallic ruthenium(II)-arene mixed phosphine complexes, [Ru(h6-p-cymene)Cl(PTA)(PPh3)]BF4 1b and [Ru(h6-C6H5CH2CH2OH)Cl(PTA)(PPh3)]BF4 2b (PTA = 1,3,5-triaza-7-phosphaadamantane), have been evaluated in vitro and compare ...

2007

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