Publications de Matthew Gibson

A minimalistic cyclic ice-binding peptide from phage display

Harm-Anton Klok, Matthew Gibson, Luciano Andres Abriata, Xudong Kong, Corey Alfred Stevens

Developing molecules that emulate the properties of naturally occurring ice-binding proteins (IBPs) is a daunting challenge. Rather than relying on the (limited) existing structure–property relationships that have been established for IBPs, here we report ...

Nature Research2021

Impact of polymer-modified gold nanoparticles on brain endothelial cells: exclusion of endoplasmic reticulum stress as a potential risk factor

Harm-Anton Klok, Matthew Gibson

A library of polymer-coated gold nanoparticles (AuNPs) differing in size and surface modifications was examined for uptake and induction of cellular stress responses in the endoplasmic reticulum (ER stress) in human brain endothelial cells (hCMEC/D3). ER s ...

Informa Healthcare2016

Selective detection of epimeric pentose saccharides at physiological pH using a fluorescent receptor

Matthew Gibson, Elizabeth Fullam, Joao Pedro De Almeida Neres

Epimerisation between ribofuranose and arabinofuranose sugars is crucial in several biosynthetic pathways, but is typically challenging to monitor. Here, we have screened for fluorescent boronic acids that can be used as molecular probes for the specific d ...

Elsevier Sci Ltd2014

Personalising speech-to-speech translation: Unsupervised cross-lingual speaker adaptation for HMM-based speech synthesis

Simon King, Matthew Gibson, Hui Liang, Lakshmi Babu Saheer, John David Scott Dines

In this paper we present results of unsupervised cross-lingual speaker adaptation applied to text-to-speech synthesis. The application of our research is the personalisation of speech-to-speech translation in which we employ a HMM statistical framework for ...

2013

Fast three-dimensional imaging of gold nanoparticles in living cells with photothermal optical lock-in Optical Coherence Microscopy

Christian Santschi, Theo Lasser, Martin Villiger, Corinne Berclaz, Christophe Pache, Matthew Gibson, Joan Goulley, Noelia Laura Bocchio, Arno Pino Bouwens

We introduce photothermal optical lock-in Optical Coherence Microscopy (poli-OCM), a volumetric imaging technique, which combines the depth sectioning of OCM with the high sensitivity of photothermal microscopy while maintaining the fast acquisition speed ...

Optical Society of America2012

Size- and Coating-Dependent Uptake of Polymer-Coated Gold Nanoparticles in Primary Human Dermal Microvascular Endothelial Cells

Harm-Anton Klok, Matthew Gibson

A library-orientated approach is used to gain understanding of the interactions of well-defined nanoparticles with primary human endothelial cells, which are a key component of the vasculature. Fifteen sequentially modified gold nanoparticles (AuNPs) based ...

American Chemical Society2012

Side-Chain Peptide-Synthetic Polymer Conjugates via Tandem "Ester-Amide/Thiol-Ene" Post-Polymerization Modification of Poly(pentafluorophenyl methacrylate) Obtained Using ATRP

Harm-Anton Klok, Maarten Danial, Matthew Gibson

Herein the concept of tandem postpolymerization modification as a versatile route to synthesize well-defined, highly functionalized polymers is introduced. Poly(pentafluorophenyl methacrylate) obtained by atom transfer radical polymerization was first modi ...

American Chemical Society2011

Sequentially Modified, Polymer-Stabilized Gold Nanoparticle Libraries: Convergent Synthesis and Aggregation Behavior

Harm-Anton Klok, Maarten Danial, Matthew Gibson

This manuscript describes a versatile, yet experimentally facile, method for producing libraries of polymer coated (core-shell type) gold nanoparticles. The synthetic principle relies on two, sequential postmodification reactions, which ensures homogeneity ...

2011

Size-Dependent LCST Transitions of Polymer-Coated Gold Nanoparticles: Cooperative Aggregation and Surface Assembly

Harm-Anton Klok, Dusko Paripovic, Matthew Gibson

Nanoparticles working together. Thermoresponsive polymer-coated nanoparticles are shown to display size dependent, cooperative, lower critical solution temperature behavior. This is exploited to direct the assembly of appropriate nanoparticles onto complem ...

Wiley-Blackwell2010

Experimentally Facile Controlled Polymerization of N-Carboxyan hydrides (NCAs), Including O-Benzyl-L-threonine NCA

Matthew Gibson

It is demonstrated here that three different alpha-amino N-carboxyanhydrides (NCAs), including for the first time O-benzyl-L-threonine NCA, can be polymerized in a controlled/"living" fashion without the need for transition metal catalysts or complex custo ...

2009

Nonfouling Polypeptide Brushes via Surface-initiated Polymerization of N-epsilon-oligo(ethylene glycol)succinate-L-lysine N-carboxyanhydride

Raphaël Barbey, Harm-Anton Klok, Matthew Gibson, Jian Wang

This contribution describes the preparation of nonfouling polypeptide brushes via surface-initiated ring-opening polymerization of oligo(ethylene glycol) modified L-lysine N-carboxyanhydrides. Circular dichroism experiments indicated that these surface-anc ...

2009

Postpolymerization modification of poly(pentafluorophenyl methacrylate): Synthesis of a diverse water-soluble polymer library

Harm-Anton Klok, Matthew Gibson

This article explores the feasibility of poly(pentafluorophenyl methacrylate) (PPFMA) prepared by reversible addition fragmentation chain transfer (RAFT) polymerization as a platform for the preparation of diverse libraries of functional polymers via postp ...

2009

Synthesis of functional polymers by post-polymerization modification

Harm-Anton Klok, Matthew Gibson, Marc Gauthier

(Figure Presented) Post-polymerization modification is based on the direct polymerization or copolymerization of monomers bearing chemoselective handles that are inert towards the polymerization conditions but can be quantitatively converted in a subsequen ...

Wiley-VCH Verlag GmbH2009

Synthesis of functional polymers by post-polymerization modification

Harm-Anton Klok, Matthew Gibson, Marc Gauthier

2009

Organogelation of sheet-helix diblock copolypeptides

Matthew Gibson

Wiley-VCH Verlag GmbH2008