Publications de Wietske Van der Zwaag

Whole-body somatotopic maps in the cerebellum revealed with 7T fMRI

The cerebellum is known to contain a double somatotopic body representation. While the anterior lobe body map has shown a robust somatotopic organization in previous fMRI studies, the representations in the posterior lobe have been more difficult to observ ...

2020

Metabolite concentration changes associated with positive and negative BOLD responses in the human visual cortex: A functional MRS study at 7 Tesla

Rolf Gruetter, Lijing Xin, Wietske Van der Zwaag, Yohan Boillat

Negative blood oxygenation-level dependent (BOLD) signal observed during task execution in functional magnetic resonance imaging (fMRI) can be caused by different mechanisms, such as a blood-stealing effect or neuronal deactivation. Electrophysiological re ...

2019

Whole brain measurements of the positive BOLD response variability during a finger tapping task at 7 T show regional differences in its profiles

Wietske Van der Zwaag, Yohan Boillat

PURPOSE: The positive BOLD response can vary across brain regions. Here, the positive BOLD responses of motor regions, including the cerebellum, were investigated by fast fMRI acquisition. METHODS: The participants were asked to perform an event-related fi ...

Wiley2019

Chronotopic maps in human supplementary motor area

Wietske Van der Zwaag, Domenica Bueti

Time is a fundamental dimension of everyday experiences. We can unmistakably sense its passage and adjust our behavior accordingly. Despite its ubiquity, the neuronal mechanisms underlying the capacity to perceive time remains unclear. Here, in two experim ...

2019

Cortical laminar assessment of T1 and T2*in the cerebellum of MS patients and controls at 7T MRI

Wietske Van der Zwaag, Yohan Boillat, Cristina Granziera

WILEY2019

Cerebellar cortical laminar analysis of T1 relaxation times at 7T MRI shows widespread cerebellar cortex damage in early relapsing-remitting MS patients but no correlation with clinical deficits

Wietske Van der Zwaag, Yohan Boillat, Cristina Granziera, Kieran O'Brien

SAGE PUBLICATIONS LTD2019

Surface-based characteristics of the cerebellar cortex visualized with ultra-high field MRI

Guillaume Bonnier, Wietske Van der Zwaag, Gunnar Krüger, Yohan Boillat, Cristina Granziera, Kieran O'Brien, Mario Joao Fartaria de Oliveira

Although having a relatively homogeneous cytoarchitectonic organization, the cerebellar cortex is a heterogeneous region characterized by different amounts of myelin, iron and protein expression profiles. In this study, we used quantitative T1 and T2* mapp ...

2018

Representations of time in human frontoparietal cortex

Wietske Van der Zwaag, Domenica Bueti

Precise time estimation is crucial in perception, action and social interaction. Previous neuroimaging studies in humans indicate that perceptual timing tasks involve multiple brain regions; however, whether the representation of time is localized or distr ...

2018

Mapping and characterization of positive and negative BOLD responses to visual stimulation in multiple brain regions at 7T

Rolf Gruetter, Wietske Van der Zwaag, João Pedro Forjaco Jorge, Patricia Figueiredo

External stimuli and tasks often elicit negative BOLD responses in various brain regions, and growing experimental evidence supports that these phenomena are functionally meaningful. In this work, the high sensitivity available at 7T was explored to map an ...

Wiley2018

High spatio-temporal resolution in functional MRI with 3D echo planar imaging using cylindrical excitation and a CAIPIRINHA undersampling pattern

Wietske Van der Zwaag, José Pedro Rebelo Ferreira Marques, Mayur Narsude, Daniel Gallichan, Olivier Benoit Thomas Reynaud

The combination of 3D echo planar imaging (3D-EPI) with a 2D-CAIPIRINHA undersampling scheme provides high flexibility in the optimization for spatial or temporal resolution. This flexibility can be increased further with the addition of a cylindrical exci ...

Wiley2018

Influence of physiological noise on accelerated 2D and 3D resting state functional MRI data at 7 T

Rolf Gruetter, Wietske Van der Zwaag, José Pedro Rebelo Ferreira Marques, João Pedro Forjaco Jorge, Olivier Benoit Thomas Reynaud

Physiological noise often dominates the blood-oxygen level-dependent (BOLD) signal fluctuations in high-field functional MRI (fMRI) data. Therefore, to optimize fMRI protocols, it becomes crucial to investigate how physiological signal fluctuations impact ...

Wiley-Blackwell2017

High-Resolution fMRI of Auditory Cortical Map Changes in Unilateral Hearing Loss and Tinnitus

Stephanie Clarke, Dimitri Nestor Alice Van De Ville, Wietske Van der Zwaag, Naghmeh Ghazaleh, Melissa Saenz

Animal models of hearing loss and tinnitus observe pathological neural activity in the tonotopic frequency maps of the primary auditory cortex. Here, we applied ultra high-field fMRI at 7 T to test whether human patients with unilateral hearing loss and ti ...

Springer Verlag2017

Upper limb cortical maps in amputees with targeted muscle and sensory reinnervation

Roberto Martuzzi, Olaf Blanke, Michel Akselrod, Wietske Van der Zwaag, Giulio Rognini, Roy Salomon, Maria Laura Blefari, Andrea Serino, Elisa Canzoneri

Neuroprosthetics research in amputee patients aims at developing new prostheses that move and feel like real limbs. Targeted muscle and sensory reinnervation (TMSR) is such an approach and consists of rerouting motor and sensory nerves from the residual li ...

Oxford University Press2017

Anatomical and functional properties of the foot and leg representation in areas 3b, 1 and 2 of primary somatosensory cortex in humans: A 7T fMRI study

Roger Gassert, Roberto Martuzzi, Olaf Blanke, Michel Akselrod, Wietske Van der Zwaag, Andrea Serino

Primary somatosensory cortex (S1) processes somatosensory information and is composed of multiple subregions. In particular, tactile information from the skin is encoded in three subregions, namely Brodmann areas (BAs) 3b, 1 and 2, with each area represent ...

2017

Metabolite concentration changes during increase of the BOLD signal in the human visual cortex: a functional magnetic resonance spectroscopy study at 7T

Rolf Gruetter, Lijing Xin, Wietske Van der Zwaag, Yohan Boillat

Sage Publications Inc2017

Sustained enhancements in inhibitory control depend primarily on the reinforcement of fronto-basal anatomical connectivity

Michaël Mouthon, Wietske Van der Zwaag, Bogdan Draganski

What are the neurophysiological determinants of sustained supra-normal inhibitory control performance? We addressed this question by coupling multimodal neuroimaging and behavioral investigations of experts in fencing who underwent more than 20,000 h of in ...

Springer Heidelberg2017

Retinotopic encoding of the Ternus-Pikler display reflected in the early visual areas

Michael Herzog, Yvonne Evelina Thunell, Wietske Van der Zwaag, Gijs Plomp

The visual representation of the world is often assumed to be retinotopic, and many visual brain areas are indeed organized retinotopically. Visual perception, however, is not based on a reference frame anchored in retinotopic coordinates. For example, whe ...

Association for Research in Vision and Ophthalmology (ARVO)2016

Three-dimensional echo planar imaging with controlled aliasing: A sequence for high temporal resolution functional MRI

Rolf Gruetter, Wietske Van der Zwaag, José Pedro Rebelo Ferreira Marques, Mayur Narsude, Daniel Gallichan

Purpose In this work, we combine three-dimensional echo planar imaging (3D-EPI) with controlled aliasing to substantially increase temporal resolution in whole-brain functional MRI (fMRI) while minimizing geometry-factor (g-factor) losses. Theory and Metho ...

Wiley-Blackwell2016

Presurgical brain mapping in epilepsy using simultaneous EEG and functional MRI at ultra-high field: feasibility and first results

François Lazeyras, Wietske Van der Zwaag, João Pedro Forjaco Jorge, Giannina Rita Iannotti

OBJECTIVES: The aim of this study was to demonstrate that eloquent cortex and epileptic-related hemodynamic changes can be safely and reliably detected using simultaneous electroencephalography (EEG)-functional magnetic resonance imaging (fMRI) recordings ...

Springer Verlag2016

Recent applications of UHF-MRI in the study of human brain function and structure: a review

Wietske Van der Zwaag, José Pedro Rebelo Ferreira Marques

The increased availability of ultra-high-field (UHF) MRI has led to its application in a wide range of neuroimaging studies, which are showing promise in transforming fundamental approaches to human neuroscience. This review presents recent work on structu ...

Wiley-Blackwell2016