Publications de Cristina Boero

Wireless Monitoring of Endogenous and Exogenous Biomolecules on an Android Interface

Giovanni De Micheli, Cristina Boero, Sandro Carrara, Irene Taurino, Camilla Baj-Rossi, Grégoire Casimir Joseph Surrel, Stefano Riario, Francesca Stradolini

Monitoring patients in intensive care units is generally expensive and time consuming. A prompter medical intervention for those critical patients is a key factor for their safety. Therefore, a system that offers immediate visualization of the monitored da ...

Institute of Electrical and Electronics Engineers2016

A System for Wireless Power Transfer and Data Communication of Long-Term Bio-Monitoring

Catherine Dehollain, Giovanni De Micheli, Cristina Boero, Sandro Carrara, Enver Gürhan Kilinç, Camilla Baj-Rossi, Seyedeh Sara Ghoreishizadeh, Franco Maloberti, Stefano Riario, Francesca Stradolini

A system for wireless power transfer and data communication of implantable bio-monitoring systems is presented. The proposed solution uses a servo-controlled power transmitter moved under the animal moving space. An x-y movable magnetic coil transmits the ...

Institute of Electrical and Electronics Engineers2015

Full System for Translational Studies of Personalized Medicine with Free-Moving Mice (invited)

Catherine Dehollain, Giovanni De Micheli, Cristina Boero, Sandro Carrara, Enver Gürhan Kilinç, Camilla Baj-Rossi, Seyedeh Sara Ghoreishizadeh, Grégoire Casimir Joseph Surrel, Stefano Riario, Francesca Stradolini

A full remotely powered system for metabolism monitoring of free-moving mice is presented here. The fully implantable sensing platform hosts two ASICs, one off-the-shelf micro-controller, four biosensors, two other sensors, a coil to receive power, and an ...

2015

Design, development, and validation of an in-situ biosensor array for metabolite monitoring of cell cultures

Marco Mazza, Giovanni De Micheli, Cristina Boero, Sandro Carrara, Jacopo Olivo, Maria Antonietta Casulli, Lorenzo Foglia

Conventional pharmaceutical processes involving cell culture growth are generally taken under control with expensive and long laboratory tests performed by direct sampling to evaluate quality. This traditional and well-established approach is just partiall ...

Elsevier2014

Do Carbon Nanotubes Contribute to Electrochemical Biosensing?

Giovanni De Micheli, Cristina Boero, Sandro Carrara, Camilla Baj-Rossi

Carbon nanotubes have been attracting a lot of interest as electron transfer mediators to enhance electrochemical biosensing. The main reason behind this is usually recognized in terms of augmented electrochemical active surface area. The aim of this paper ...

Elsevier2014

Sub-mW Reconfigurable Interface IC for Electrochemical Sensing

Giovanni De Micheli, Cristina Boero, Sandro Carrara, Camilla Baj-Rossi, Seyedeh Sara Ghoreishizadeh

The IronIC project has the aim of developing a fully implantable and remotely powered platform for the real- time monitoring of human metabolites. In this paper we present a mixed-signal interface IC for the electrochemical sensing data acquisition chain. ...

IEEE2014

Lab-on-a-chip implants: a mini laboratory under the skin

Giovanni De Micheli, Cristina Boero, Sandro Carrara

2013

Remote System for Monitoring Animal Models With Single-Metabolite Bio-Nano-Sensors

Léandre Bolomey, Eric Meurville, Giovanni De Micheli, Cristina Boero, Andrea Cavallini, Sandro Carrara

A novel system for remote monitoring of metabolism in an animal model is proposed in this paper. The system is obtained by integrating bio-nano-sensors to detect single- metabolites, an electrochemical front-end made with off-the-shelf components, a radio ...

Institute of Electrical and Electronics Engineers2013

Implantable devices: the future of blood monitoring? (Editorial)

Giovanni De Micheli, Cristina Boero, Sandro Carrara

Implantable devices can be developed for the simultaneous monitoring of a specific group of key metabolites, identified by more complex techniques, such as mass spectroscopy- or nuclear magnetic -based analysis.. Since there is a strong correlation between ...

2013

New Approaches for Carbon Nanotubes-Based Biosensors and Their Application to Cell Culture Monitoring

Giovanni De Micheli, Cristina Boero, Sandro Carrara, Jacopo Olivo

Amperometric biosensors are complex systems and they require a combination of technologies for their development. The aim of the present work is to propose a new approach in order to develop nanostructured biosensors for the real-time detection of multiple ...

Ieee-Inst Electrical Electronics Engineers Inc2012

Integrated Biosensors for Personalized Medicine

Giovanni De Micheli, Cristina Boero, Sandro Carrara, Irene Taurino, Camilla Baj-Rossi

Biosensors are heterogenous devices, incorporating biological struc- tures combined with electronics, optical or other readout systems. They have been developed for detecting different biomolecules and/or pathogens and represent a key technology for advanc ...

Ieee2012

A Self-Contained System With CNTs-Based Biosensors for Cell Culture Monitoring

Giovanni De Micheli, Cristina Boero, Sandro Carrara, Jacopo Olivo

Biosensors have been applied to disparate fields, especially for endogenous compounds such as glucose and lactate. The main areas of application are certainly related to medical and diagnostic purposes. However, metabolic monitoring can be also of interest ...

2012

Electrochemical Biosensors for On-line Monitoring of Cell Culture Metabolism

Cristina Boero

Current research in the biotechnological field is hampered by the lack of available technologies dedicated to cell monitoring. While on the one hand physicochemical parameters, such as pH, temperature, cell density and adhesion, can be monitored quite easi ...

EPFL2012

Targeting of multiple metabolites in neural cells monitored by using protein-based carbon nanotubes

Giovanni De Micheli, Cristina Boero, Sandro Carrara, Giovanna Del Vecchio

Microdevices dedicated to monitor metabolite levels have recently enabled many applications in the field of cell analysis, to monitor cell growth and development of numerous cell lines. By combining the traditional technology used for electrochemical biose ...

2011

Highly Sensitive Carbon Nanotube-Based Sensing for Lactate and Glucose Monitoring in Cell Culture

Giovanni De Micheli, Cristina Boero, Sandro Carrara, Giovanna Del Vecchio

Monitoring of metabolic compounds in cell cultures can provide real-time information of cell line status. This is particularly important in those lines not fully known, as the case of embryonic and mesenchymal cells. On the other hand, such approach can pa ...

Institute of Electrical and Electronics Engineers2011

Long-term Biosensors for Metabolite Monitoring by using Carbon Nanotubes

Giovanni De Micheli, Cristina Boero, Sandro Carrara

The key-point for the development of an amperometric sensor is the immobilization of the enzyme. In the present work we use biosensors based on glucose oxidase (GOD) onto electrodes nanostructured with carbon nanotubes (CNT), to be employed in cell culture ...

2011

An Integrated Platform for Advanced Diagnostics

Giovanni De Micheli, Cristina Boero, Sandro Carrara, Seyedeh Sara Ghoreishizadeh

The objective of this work is the systematic study of the use of electrochemical readout for advanced diagnosis and drug monitoring. Whereas to date various electrochemical principles have been studied and successfully tested, they typically operate on a s ...

2011

Carbon Nanotubes-Based Electrochemical Sensing for Cell Culture Monitoring

Giovanni De Micheli, Cristina Boero, Sandro Carrara, Giovanna Del Vecchio

Monitoring of metabolic compounds, such as glucose and lactate, is extensively reported in literature, especially for clinical purposes. Instead, the application of such technologies for monitoring metabolites in cell cultures has not been explored. From o ...

2010

Sensitivity Enhancement by Carbon Nanotubes: Applications to Stem Cell Cultures Monitoring

Giovanni De Micheli, Cristina Boero, Sandro Carrara

Nano-biosensing provides new tools to investigate cellular differentiation and proliferation. Upon the various metabolic compounds secreted by cells during life cycles, glucose, lactate and hydrogen peroxide (H2O2) are of first interest. Nanostructured ele ...

2009

Amperometric biosensor with nanostructured electrodes by using multi-alled carbon nanotubes for glucose detection in cell culture medium

Giovanni De Micheli, Cristina Boero, Sandro Carrara

The monitoring of metabolic compounds such as glucose is largely reported in literature. The applications of this type of analysis are mainly related to clinical purposes, e.g. in diabetes pathology, where a lot of studies are presented in literature. Rece ...

2009