Publications de Bo Song | EPFL Graph Search

A precise polyrotaxane synthesizer

Mechanically interlocked molecules are likely candidates for the design and synthesis of artificial molecular machines. Although polyrotaxanes have already found niche applications in exotic materials with specialized mechanical properties, efficient synth ...

American Association for the Advancement of Science2020

Synthesis and cell localization of self-assembled dinuclear lanthanide bioprobes

Jean-Claude Bünzli, Caroline Vandevyver, Anne-Sophie Chauvin, Bo Song

Lanthanide bioprobes and bioconjugates are ideal luminescent stains in view of their low propensity to photobleaching, sharp emission lines and long excited state lifetimes permitting time-resolved detection for enhanced sensitivity. In this paper, we expa ...

Royal Society, The2013

Reinforcing multiwall carbon nanotubes by electron beam irradiation

László Forró, Jin Won Seo, Arnaud Magrez, Richard Meunier, Martial Duchamp, Marijana Mionic Ebersold, Bo Song, Rita Smajda

We study the effect of electron beam irradiation on the bending modulus of multiwall carbon nanotubes grown by chemical vapor deposition. Atomic force microscopy observations of the nanotube deflection in the suspended-beam geometry suggest an internal, re ...

2010

Fast Immunohistochemical BioMarker Detection Device for Cancer Tissue Slices

Martinus Gijs, Jean-Claude Bünzli, Caroline Vandevyver, Bo Song, Ata Tuna Ciftlik, Hans-Anton Lehr

2010

Multiphoton-Excited Luminescent Lanthanide Bioprobes: Two- and Three-Photon Cross Sections of Dipicolinate Derivatives and Binuclear Helicates

Jean-Claude Bünzli, Majed Chergui, Anne-Sophie Chauvin, Frank van Mourik, Andrea Cannizzo, Bo Song, Gerald Auböck, Svetlana Eliseeva

Multiphoton excited luminescent properties of water-soluble EuIII and TbIII complexes with derivatives of dipicolinic acid functionalized with a polyoxyethylene pendant arm and terminal groups, [Eu(LOMe)3]3-, [Eu(LNH2)3]3-, and [Tb(LOH)3]3-, as well as of ...

2010

Bioconjugated lanthanide luminescent helicates as multilabels for lab-on-a-chip detection of cancer biomarkers

Martinus Gijs, Jean-Claude Bünzli, Caroline Vandevyver, Anne-Sophie Chauvin, Venkataragavalu Sivagnanam, Bo Song, Vanesa Fernandez Moreira, Hans-Anton Lehr

The lanthanide binuclear helicate [Eu2(LC2(CO2H))3] is coupled to avidin to yield a luminescent bioconjugate EuB1 (Q ¼ 9.3%, s(5D0) ¼ 2.17 ms). MALDI/TOF mass spectrometry confirms the covalent binding of the Eu chelate and UV-visible spectroscopy allows o ...

2010

On-chip immunoassay using electrostatic assembly of streptavidin-coated bead micropatterns

Martinus Gijs, Caroline Vandevyver, Venkataragavalu Sivagnanam, Bo Song, Hui Yang

We propose an original concept for a sandwich immunoassay that is completely performed on-chip using streptavidin-coated beads as substrate. The latter are electrostatically self-assembled on aminosilane micropatterns at the bottom of a microfluidic channe ...

2009

Time-resolved lanthanide luminescence for lab-on-a-chip detection of biomarkers on cancerous tissues

Martinus Gijs, Jean-Claude Bünzli, Caroline Vandevyver, Venkataragavalu Sivagnanam, Bo Song, Hans-Anton Lehr

PDMS-based microfluidic devices combined with lanthanide-based immunocomplexes have been successfully tested for the multiplex detection of biomarkers on cancerous tissues, revealing an enhanced sensitivity compared to classical organic dyes. ...

2009

Luminescent Bimetallic Lanthanide Bioprobes for Cellular Imaging with Excitation in the Visible-Light Range

Jean-Claude Bünzli, Caroline Vandevyver, Frédéric Gumy, Anne-Sophie Chauvin, Bo Song

A series of homoditopic ligands H2LCX (X=4–6) has been designed to self-assemble with lanthanide ions (LnIII), resulting in neutral bimetallic helicates of overall composition [Ln2ACHTUNGTRENUNG(LCX)3] with the aim of testing the influence of substituents ...

2009

A versatile method for quantification of DNA and PCR products based on time-resolved EuIII luminescence

Jean-Claude Bünzli, Caroline Vandevyver, Anne-Sophie Chauvin, Bo Song

A versatile and robust method for the determination of DNA and PCR products (

2008

Effect of the length of polyoxyethylene substituents on luminescent bimetallic lanthanide bioprobes

Jean-Claude Bünzli, Caroline Vandevyver, Anne-Sophie Chauvin, Bo Song

The new homoditopic ligand

H_2L^{C2'}

self-assembles with lanthanide ions (

Ln^{III}

) to yield neutral bimetallic helicates of overall composition

[Ln_2(L^{C2'})_3]

; it is fitted with two hexakis(oxyethylene) chains to test their effects on the thermo ...

2008

Lanthanide Bimetallic Helicates for in Vitro Imaging and Sensing

Jean-Claude Bünzli, Caroline Vandevyver, Steve Comby, Anne-Sophie Chauvin, Bo Song

As the need for targeting luminescent biolabels increases, for mapping selected analytes, imaging of cells and organs, and tracking in cellulo processes, lanthanide bimetallic helicates are emerging as versatile bioprobes. The wrapping of three ligand stra ...

2008

A Versatile Ditopic Ligand System for Sensitizing the Luminescence of Bimetallic Lanthanide Bio-Imaging Probes

Jean-Claude Bünzli, Caroline Vandevyver, Steve Comby, Anne-Sophie Chauvin, Bo Song

The homoditopic ligand 6,6’- [methylenebis(1-methyl-1H-benzimid- azole-5,2-diyl)]bis(4-{2-[2-(2-methoxy- ethoxy)ethoxy]ethoxy}pyridine-2-carboxylic acid) (H2LC2) has been tailored to self-assemble with lanthanide ions (LnIII), which results in the formatio ...

2008

Time-resolved luminescence microscopy of bimetallic lanthanide helicates in living cells

Jean-Claude Bünzli, Caroline Vandevyver, Anne-Sophie Chauvin, Bo Song

The cellular uptake mechanism and intracellular distribution of emissive lanthanide helicates have been elucidated by time-resolved luminescence microscopy (TRLM). The helicates are non-cytotoxic and taken up by normal (HaCat) and cancer (HeLa, MCF-7) cell ...

2008

A Polyoxyethylene-Substituted Bimetallic Europium Helicate for Luminescent Staining of Living Cells

Jean-Claude Bünzli, Caroline Vandevyver, Steve Comby, Anne-Sophie Chauvin, Bo Song

The homoditopic ligand

H_2L^{C3}

has been designed to form neutral triple-stranded bimetallic helicates of overall composition [

Ln_2(L^{C3})_3

]. The grafting of the polyoxyethylene fragments ensures water solubility and also favors cell penetration whi ...

2007