Publications de Rajwinder Lehal

In vitro anti-lymphoma activity of the first-in-class pan-NOTCH transcription inhibitor CB-103

Freddy Radtke, Rajwinder Lehal, Maximilien Murone, Andrea Rinaldi

WILEY2022

Pharmacological disruption of the Notch transcription factor complex

Freddy Radtke, Rajwinder Lehal, Ute Koch, Nadine Fournier, Linlin Cao, Michele Vigolo, Jelena Zaric

Notch pathway signaling is implicated in several human cancers. Aberrant activation and mutations of Notch signaling components are linked to tumor initiation, maintenance, and resistance to cancer therapy. Several strategies, such as monoclonal antibodies ...

National Academy of Sciences2020

Direct targeting of NOTCH transcription complex by a novel small molecule CB-103 circumvents dose-limiting toxicities associated with pan-NOTCH inhibitors

Freddy Radtke, Charlotte Marie Urech-Varenne, Rajwinder Lehal, Maximilien Murone, Michele Vigolo, Jelena Zaric

AMER ASSOC CANCER RESEARCH2019

Pharmacological activity of CB-103: An oral pan-NOTCH inhibitor targeting the NOTCH transcription complex

Freddy Radtke, Rajwinder Lehal, Maximilien Murone

Oxford University Press2018

Characterization and profiling of CB-103, a novel small-molecule protein-protein interaction inhibitor targeting the NOTCH transcription complex

Freddy Radtke, Charlotte Marie Urech-Varenne, Rajwinder Lehal, Maximilien Murone, Michele Vigolo

AMER ASSOC CANCER RESEARCH2018

Pharmacological Activity Of Cb-103-An Oral Pan-Notch Inhibitor With A Novel Mode Of Action

Manuel Bauer, Freddy Radtke, Rajwinder Lehal, Maximilien Murone

Ferrata Storti Foundation2017

Pharmacological activity of CB-103: An oral pan-NOTCH inhibitor with a novel mode of action

Manuel Bauer, Freddy Radtke, Rajwinder Lehal, Maximilien Murone

Oxford Univ Press2017

Development Of A Novel First-In-Class Oral Inhibitor Of The Notch Pathway

Gerardo Turcatti, Freddy Radtke, Rajwinder Lehal, Viktoria Reinmüller

Ferrata Storti Foundation2016

Alzheimer's disease mutations in APP but not γ-secretase modulators affect epsilon-cleavage-dependent AICD production

Thomas Lemmin, Patrick Fraering, Freddy Radtke, Rajwinder Lehal, Jemila Houacine, Matteo Dal Peraro, Mitko Dimitrov, Andrzej Jacek Fligier

Pathological amino-acid substitutions in the amyloid precursor protein (APP) and chemical gamma-secretase modulators affect the processing of APP by the gamma-secretase complex and the production of the amyloid-beta peptide A beta 42, the accumulation of w ...

Nature Publishing Group2013

Inhibitors of notch signalling pathway and use thereof in treatment of cancers

Freddy Radtke, Rajwinder Lehal, Jieping Zhu, Viktoria Reinmüller

The present invention relates to use of inhibitors of Notch signalling pathway selected from the group consisting of 6-(4-Tert-Butylphenoxy)Pyridin-3-Amine (I3), its derivatives, in treating and/or preventing cancers. ...

2013

Stem cells living with a Notch

Freddy Radtke, Rajwinder Lehal, Ute Koch

Notch signaling has been shown over the past few decades to play fundamental roles in a plethora of developmental processes in an evolutionarily conserved fashion. Notch-mediated cell-to-cell signaling is involved in many aspects of embryonic development a ...

Company of Biologists2013

Generation and characterization of a Notch1 signaling-specific reporter mouse line

Yann Barrandon, Stéphanie Claudinot, Freddy Radtke, Rajwinder Lehal, Luca Pellegrinet

Signaling through the Notch1 receptor is essential for the control of numerous developmental processes during embryonic life as well as in adult tissue homeostasis and disease. Since the outcome of Notch1 signaling is highly context-dependent, and its prec ...

Wiley-Blackwell2012

Very High Throughput Electrical Cell Lysis and Extraction of Intracellular Compounds Using 3D Carbon Electrodes in Lab-on-a-Chip Devices

Philippe Renaud, Freddy Radtke, Rajwinder Lehal, Rodrigo Martinez Duarte

Here we present an electrical lysis throughput of 600 microliters per minute at high cell density (108 yeast cells per ml) with 90% efficiency, thus improving the current common throughput of one microliter per minute. We also demonstrate the extraction of ...

2012

Notch Signaling In Normal And Malignant T-Cells

Freddy Radtke, Rajwinder Lehal, Caroline Poisson, Ute Koch, Fabian Junker

Elsevier Science Inc2012

Identification and Preclinical Validation of Novel Inhibitors of the Notch Pathway

Rajwinder Lehal

Notch signaling is among one of the highly conserved developmental pathways. Because of its role in the regulation of stem cell self-renewal and cell fate decisions, Notch signaling maintains tissue homeostasis in several organs such as thymus, skin and in ...

EPFL2011